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The effect of intraurethral heparin on inflammation and spongiofibrosis in a rat model of experimentally induced urethral trauma

  • Urology - Original Paper
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Abstract

Aim

To determine the effect of heparin administered during the early post urethral trauma period on inflammation and spongiofibrosis in rats.

Materials and methods

The study included 24 male rats that were randomized into 3 groups of 8 each. The urethra was traumatized using a 24-G needle sheath in all rats. Group 1 (control group) received intraurethral saline 0.9% injected b.i.d. for 27 days, group 2 received intraurethral Na-heparin (liquemine-Roche) 1500 IU kg−1 injected b.i.d. for 27 days, and group 3 received intraurethral Na-heparin 1500 IU kg−1 injected b.i.d and saline 0.9% s.i.d. for 27 days. On day 28 the rats’ penises were degloved and penectomy was performed. Inflammation, spongiofibrosis, and congestion in the urethra were investigated in each group.

Results

A statistically significant difference was found between the three groups (control, heparin, and heparin + saline) in the histopathological status of spongiofibrosis, inflammation, and congestion, respectively (P = 0.0001, P = 0.002, P = 0.0001). Severe spongiofibrosis was observed in six (75%) of the rats in group 1 (control group), whereas severe spongiofibrosis was not observed in group 2 (heparin) or group 3 (heparin + saline).

Conclusion

We observed that intraurethral Na-heparin 1500 IU kg−1 injectioned during the early posturethral trauma period in rats significantly decreased inflammation, spongiofibrosis, and congestion.

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Authors and Affiliations

  1. Department of Urology, Dr. A.Y. Oncology Training and Research Hospital, University of Health Sciences, Demetevler, Ankara, Turkey

    Fatih Hızlı, Aykut Demirci & Halil Başar

  2. Department of Pathology, Dr. A.Y. Oncology Training and Research Hospital, University of Health Sciences, Demetevler, Ankara, Turkey

    Emine Benzer

  3. Mediterranean Agricultural Research Institute, Adana, Turkey

    Hatice Hızlı

Authors
  1. Fatih Hızlı
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  2. Aykut Demirci
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  3. Emine Benzer
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  4. Hatice Hızlı
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  5. Halil Başar
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Contributions

Concept and study design: FH. Data collection: FH and AD. Analysis and writing: FH. Supervision and critical review: FH, HH, EB, HB and AD. Statistical analysis: HH.

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Correspondence to Fatih Hızlı.

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Hızlı, F., Demirci, A., Benzer, E. et al. The effect of intraurethral heparin on inflammation and spongiofibrosis in a rat model of experimentally induced urethral trauma. Int Urol Nephrol 55, 1421–1426 (2023). https://doi.org/10.1007/s11255-023-03613-1

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  • DOI: https://doi.org/10.1007/s11255-023-03613-1

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