Abstract
Coriandrum sativum L. (coriander), which is an annual herb of the Apiaceae family, has been traditionally used as a remedy. Here we tested whether heated extract of coriander leaf protects nigral dopaminergic neurodegeneration after exposure to 6-hydroxydopamine (6-OHDA). After injection of 6-OHDA into the rat substantia nigra pars compacta (SNpc), dopaminergic degeneration, which was determined by tyrosine hydroxylase immunostaining, was rescued by co-injection of CaEDTA, an extracellular Zn2+ chelator, suggesting that extracellular Zn2+ influx is involved in neurodegeneration. Both intracellular Zn2+ dysregulation determined by ZnAF-2 fluorescence and dopaminergic degeneration in the SNpc induced by 6-OHDA were rescued by co-injection of 0.25% coriander extract, which also reduced reactive oxygen species (ROS) production in the SNpc determined by aminophenyl fluorescein fluorescence. The present study suggests that coriander leaf extract protects nigral dopaminergic neurodegeneration induced by intracellular Zn2+ dysregulation. It is likely that the nutraceutical property of coriander leaf extract contributes to the protection via reducing ROS production.
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Conceptualization; Atsushi Takeda: Data curation; Haruna Tamano: Formal analysis; Nana Saeki, Azusa Takeuchi, Misa Katahira, Ryusuke Nishio, Haruna Tamura: Methodology; Nana Saeki, Atsushi Takeda: Project administration; Atsushi Takeda: Resources; Atsushi Takeda: Software; Nana Saeki: Supervision; Haruna Tamano: Validation; Atsushi Takeda: Roles/Writing—original draft; Atsushi Takeda: Writing—review & editing; Atsushi Takeda.
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Saeki, N., Tamano, H., Takeuchi, A. et al. Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats. Plant Foods Hum Nutr 77, 455–459 (2022). https://doi.org/10.1007/s11130-022-00999-8
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DOI: https://doi.org/10.1007/s11130-022-00999-8