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Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience

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Abstract

Purpose

Acromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported that GNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study.

Methods

Thirty consecutive acromegalic patients (20 females and 10 males; mean age, 60.9 ± 11.9 years) who underwent abdominal contrast-enhanced computed tomography or magnetic resonance imaging between 2007 and 2015 at Kobe University Hospital were recruited. We also analyzed the relationship between presence of pancreatic cystic lesions and somatic GNAS mutations in pituitary tumors.

Results

Seventeen of 30 (56.7%) patients studied had pancreatic cystic lesions. Nine of 17 patients (52.9%) were diagnosed with IPMNs based on imaging findings. These results suggest that the prevalence of IPMNs may be higher in acromegalic patients in acromegalic patients than historically observed in control patients (up to 13.5%). In patients with pancreatic cystic lesions, the mean patient age was higher and the duration of disease was longer than in those without pancreatic cystic lesions (67.0 ± 2.3 vs. 53.0 ± 2.7 years, p < 0.001, 15.5 ± 2.4 vs. 7.3 ± 2.8 years, p = 0.04). There were no differences in serum growth hormone levels or insulin-like growth factor standard deviation scores between these two groups (21.3 ± 6.4 vs. 23.0 ± 7.4 ng/ml, p = 0.86, 6.6 ± 0.5 vs. 8.0 ± 0.6, p = 0.70). Neither the presence of somatic GNAS mutation in a pituitary tumor nor low signal intensity of the tumor in T2 weighted magnetic resonance imaging was associated with the presence of pancreatic cystic lesions.

Conclusions

These data demonstrate that old or long-suffering patients with acromegaly have a higher prevalence of pancreatic cystic lesions. Moreover, the prevalence of pancreatic cystic lesions may be increased in acromegalic patients.

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Acknowledgements

We are grateful to Ms. M. Kitamura and Ms. C. Ogata for providing excellent assistance. This work was supported in part by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education Science, Culture, Sports, Science, and Technology (15K09432, 24790945, 23659477, and 23591354), Grants-in-Aid for Scientific Research (research on hypothalamic-hypophyseal disorders) from the Ministry of Health, Labor and Welfare of Japan, Novo Nordisk, the Daiichi-Sankyo Foundation of Life Science, the Foundation of Growth Science, and the Naito Foundation.

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Authors and Affiliations

  1. Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

    Yukiko Odake, Masaaki Yamamoto, Kenichi Yoshida, Ryusaku Matsumoto, Hironori Bando, Kentaro Suda, Wataru Ogawa & Yutaka Takahashi

  2. Division of Diabetes and Endocrinology, Kobe University Hospital, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Hidenori Fukuoka, Hitoshi Nishizawa & Genzo Iguchi

  3. Department of Gastroenterology, Kobe University Graduate School of Medicine, Kobe, Japan

    Yoshifumi Arisaka

  4. Department of Medical and Healthcare Systems, Kobe University Graduate School of Medicine, Kobe, Japan

    Junya Konishi

  5. Department of Hypothalamic and Pituitary Surgery, Toranomon Hospital, Tokyo, Japan

    Shozo Yamada

Authors
  1. Yukiko Odake
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  2. Hidenori Fukuoka
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  3. Masaaki Yamamoto
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  4. Yoshifumi Arisaka
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  5. Junya Konishi
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  6. Kenichi Yoshida
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  7. Ryusaku Matsumoto
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  8. Hironori Bando
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  9. Kentaro Suda
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  10. Hitoshi Nishizawa
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  11. Genzo Iguchi
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  12. Shozo Yamada
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  13. Wataru Ogawa
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  14. Yutaka Takahashi
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Corresponding author

Correspondence to Hidenori Fukuoka.

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Odake, Y., Fukuoka, H., Yamamoto, M. et al. Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience. Pituitary 20, 509–514 (2017). https://doi.org/10.1007/s11102-017-0810-1

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  • DOI: https://doi.org/10.1007/s11102-017-0810-1

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