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Changing presentation of acromegaly in half a century: a single-center experience

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Abstract

Objective

Investigate the changes in the characteristics of presentation, in patients with acromegaly over a period of approximately half a century.

Methods

The medical records of patients diagnosed with acromegaly between 1980 and 2023 were retrospectively reviewed. The collected data were examined to assess any changes observed over the years and a comparison was made between the characteristics of patients diagnosed in the last decade and those diagnosed in previous years.

Results

A total of 570 patients were included in the study, 210 (37%) patients were diagnosed in the last decade. Patients diagnosed before 2014 had longer symptom duration before diagnosis, advanced age, larger pituitary adenomas, higher incidence of cavernous sinus invasion, and higher GH and IGF-1 levels than those diagnosed last decade (p < 0.05, for all). Furthermore, the patients diagnosed before 2014 had a lower rate of surgical remission (p < 0.001), and a higher prevalence of comorbidities such as diabetes, hypertension, colon polyps, and thyroid cancer at the time of diagnosis (p < 0.05, for all).

Conclusion

There may be a trend for earlier detection of patients with acromegaly.

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Data Availability

All data obtained or analyzed as part of this study are included in this article [and/or] its tables. The data archive can be made available on request. Further requests can be directed to the corresponding author.

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Funding

This study received no specific grants from public, commercial, or nonprofit entities.

Author information

Authors and Affiliations

  1. Department of Endocrinology, Metabolism, and Diabetes, Istanbul University-Cerrahpasa, 34098, Istanbul, Türkiye

    Ahmet Numan Demir, Cem Sulu, Zehra Kara, Serdar Sahin & Pinar Kadioglu

  2. Department of Neurosurgery, Health Sciences University, Kartal Doktor Lütfi Kırdar City Hospital, Istanbul, Türkiye

    Dilan Ozaydin

  3. Department of Internal Medicine, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Ozge Sonmez

  4. Department of Endocrinology, Metabolism, and Diabetes, Demiroglu Bilim University, Istanbul, Türkiye

    Fatma Ela Keskin

  5. Department of Neurosurgery, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Necmettin Tanriover

  6. Department of Neurosurgery, Istinye University, Istanbul, Türkiye

    Nurperi Gazioglu

  7. Pituitary Center, Istanbul University-Cerrahpasa, Istanbul, Türkiye

    Necmettin Tanriover, Nurperi Gazioglu & Pinar Kadioglu

Authors
  1. Ahmet Numan Demir
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  2. Cem Sulu
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Contributions

All authors made substantial contributions to the conception and design and/or data collection and/or analysis and interpretation of the data; participated in writing the article or critically revised it for important intellectual content; gave final approval for the version to be submitted.

Corresponding author

Correspondence to Pinar Kadioglu.

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Competing interests

The authors have no relevant financial or non-financial and declare no conflict of interest.

Ethical Statement

The study conformed to the ethical principles for medical research with human participants as described in the Declaration of Helsinki of the World Medical Association. The Ethics Committee of Istanbul-University-Cerrahpaşa approved the study (approval number: 701566).

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Signed informed consent was obtained from all study participants.

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Demir, A.N., Sulu, C., Kara, Z. et al. Changing presentation of acromegaly in half a century: a single-center experience. Pituitary 26, 573–582 (2023). https://doi.org/10.1007/s11102-023-01344-1

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