In rats with acute circulatory disturbances in one of the brain hemispheres resulting from ligation of the a. carotis or microembolization of the cortical blood vessels after intra-arterial injection of suspension of adipocytes, the expression of vascular endothelial growth factor (VEGF) in the cortex of this hemisphere was temporarily decreased. This event can be considered a pathogenetic factor affecting the regenerative processes after ischemization of the cortex. Weakening of VEGF expression was probably a factor providing prolongation of the ischemia-induced degenerative phenomena. The use of an immunomodulator, Immunofan, decreased the intensity of drop in the VEGF expression after transitory cortical ischemia, and this led to more favorable conditions for postischemic recovery, decreased the intensity of neurodegenerative processes, and led to an increase in the number of gliocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. M. Rosenstein, J. M. Krum, and C. Ruhrberg, “VEGF in the nervous system,” Organogenesis, 6, No. 2, 107-114 (2010).
T. Licht and E. Keshet, “Delineating multiple functions of VEGF-A in the adult brain,” Cell. Mol. Life Sci., 70, No. 10, 1727-1737 (2013).
F. Mackenzie and C. Ruhrberg, “Diverse roles for VEGF-A in the nervous system,” Development, 139, 1371-1380 (2012).
Y. Ma, A. Zechariah, Y. Qu, and D. M. Hermann, “Effects of vascular endothelial growth factor in ischemic stroke,” J. Neurosci. Res., 90, No. 10, 1873-1882 (2012).
T. Licht, R. Eavri, I. Goshen, et al., “VEGF is required for dendritogenesis of newly born olfactory bulb interneurons,” Development, 137, No. 2, 261-271 (2010).
Patent No. 34604 of Ukraine, MPK G09B 23/00, The Technique for Modelling of Ischemic Damage to the Brain [in Ukrainian], O. M. Grabovyi, L. M. Yaremenko, N. G. Panishina, Published 11.08.08, Byull. No. 15.
L. M. Yaremenko and O. M. Grabovyi, “The state of population of lymphocytes under conditions of modelling of circulatory disturbance in the left hemisphere of the rat brain and its correction,” Immunol. Allergol., No. 1, 40-44 (2009).
O. M. Grabovyi and L. M. Yaremenko, “The state of cerebral hemispheres under conditions of modelling of disturbed circulation and after correction of accompanying changes in the immune system in rats,” Nauk. Visn. Bogomolets Nat. Med. Univ., No. 4, 28-33 (2009).
V. V. Lebedev and S. A. Novikov, “Hydrophilic hexapeptide immunofan, a hyperactive regulator of transport proteins of multiple medical resistance,” Byull. Éksp. Biol. Med., 142, No. 12, 649-651 (2006).
A. V. Karaulov, “Molecular/biological substantiation of the use of immunofan in clinical practice,”, Lechashchii Vrach, No. 4, 46-47 (2000).
Yu. A. Belozertsev and S. V. Yuntev, “Examination of neuroprotector and nootropic effects of agents in pathology of the CNS,” Zabaikal. Med. Vestn., No. 2, 42-45 (2008).
P. D. Hurn and I. M. Macrae, “Estrogen as a neuroprotectant in stroke,” J. Cerebr. Blood Flow Metab., 20, 631-652 (2000).
A. Liesz, E. Suri-Payer, C. Veltkamp, et al., “Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke,” Nat. Med., 15, 192-199 (2009).
J. T. Walsh, J. Zheng, I. Smirnov, et al., “Regulatory T cells in central nervous system injury: a double-edged sword,” J. Immunol., 193, No. 10, 5013-5022 (2014).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yaremenko, L.M., Grabovyi, O.O. & Grabovyi, O.M. Expression of Vascular Endothelial Growth Factor in the Rat Cerebral Cortex after Blood Supply Disturbances and Immunocorrection of Their Consequences. Neurophysiology 48, 354–359 (2016). https://doi.org/10.1007/s11062-017-9609-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11062-017-9609-y