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A Hybrid Coumarin-Semifluorescein-Based Fluorescent Probe for the Detection of Cysteine

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Abstract

A new type of turn-on fluorescent probe CF-AC for the detection of Cys was firstly reported. The probe exhibited an excellent response to Cys with high selectively and sensitivity. In the presence of Cys, two fluorescence emission peaks at 525 nm and 650 nm appeared accompanied by the fluorescence color change from blue to red. Morever, the probe had good biocompatibility and could be successfully used for fluorescence imaging of Cys in MCF-7 cells.

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Acknowledgments

This work was supported by Major Project of the Civil Aviation Administration of China (MHRD20160103), National Natural Science Foundation of China (NSFC.21602051).

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Author notes

  1. Xuhong Jia and Changhe Niu contributed equally to this work.

Authors and Affiliations

  1. College of Aviation Safety Engineering, Civil Aviation Flight University of China, Guanghan, Sichuan, 618307, People’s Republic of China

    Xuhong Jia & Yuanhua He

  2. Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, People’s Republic of China

    Changhe Niu

  3. College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, People’s Republic of China

    Yuanchao Sun & Heng Liu

Authors
  1. Xuhong Jia
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  2. Changhe Niu
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  3. Yuanhua He
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  4. Yuanchao Sun
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  5. Heng Liu
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Corresponding authors

Correspondence to Yuanhua He or Heng Liu.

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Jia, X., Niu, C., He, Y. et al. A Hybrid Coumarin-Semifluorescein-Based Fluorescent Probe for the Detection of Cysteine. J Fluoresc 28, 1059–1064 (2018). https://doi.org/10.1007/s10895-018-2269-5

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  • DOI: https://doi.org/10.1007/s10895-018-2269-5

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