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Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer’s disease

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Abstract

Alzheimer’s disease (AD) is the leading cause of dementia, affecting millions of people worldwide. Oxidative stress contributes towards induction of neurodegeneration. It is one of the reasons behind initiation and progression of Alzheimer’s disease. Understanding of oxidative balance and restoration of oxidative stress has demonstrated its effectiveness in the management of AD. Various natural and synthetic molecules have been found to be effective in different models of AD. Some clinical studies also support the use of antioxidants for prevention of neurodegeneration in AD. In this review we are summarizing the development of antioxidants to restrict oxidative stress induced neurodegeneration in AD.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India

    Sonal Dubey

  2. Acharya & BM Reddy College of Pharmacy, Bengaluru, Karnataka, 560107, India

    Ekta Singh

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  1. Sonal Dubey
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  2. Ekta Singh
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by SD and ES. The first draft of the manuscript was written by SD and ES and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Sonal Dubey.

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Dubey, S., Singh, E. Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer’s disease. Inflammopharmacol 31, 717–730 (2023). https://doi.org/10.1007/s10787-023-01173-5

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