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The role of magnesium in different inflammatory diseases

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Abstract

Magnesium deficiency (MgD) can cause inflammation in human body. The known mechanisms of inflammation caused by MgD include activation of phagocytic cells, opening of calcium channels, activation of the N-methyl-d-aspartate (NMDA) receptor, and activation of nuclear factor (NF)-κB. In addition, MgD causes systemic stress response through neuroendocrinological pathways. The inflammation caused by MgD can result in pro-atherogenic changes in the metabolism of lipoproteins, endothelial dysfunction, and high blood pressure. Studies suggest that magnesium may play an important role in the pathophysiology of some inflammatory diseases. Several clinical trials and laboratory studies have been done on the functional role of magnesium. In this study, we review some inflammatory diseases, in which the magnesium has a role in their pathophysiology. Among these diseases, diabetes, asthma, preeclampsia, atherosclerosis, heart damage, and rheumatoid arthritis have been highlighted.

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Authors and Affiliations

  1. Rheumatology Research Center, Tehran University of Medical Sciences, P.O.Box: 14117-13137, Tehran, Iran

    Abbas Shahi, Saeed Aslani & Mahdi Mahmoudi

  2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Abbas Shahi

  3. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Abbas Shahi

  4. Department of Medical Immunology, School of Medicine, Fasa University of Medical Sciences, P.O. Box: 74616-86688, Fasa, Iran

    MohammadReza Ataollahi

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  1. Abbas Shahi
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  2. Saeed Aslani
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Shahi, A., Aslani, S., Ataollahi, M. et al. The role of magnesium in different inflammatory diseases. Inflammopharmacol 27, 649–661 (2019). https://doi.org/10.1007/s10787-019-00603-7

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