Summary
In twelve rheumatoid arthritis (RA)patients, receiving only nonsteroid antiinflammatory therapy, Superoxide anion (0 −2 ) generation by polymorphonuclear leucocytes (PMNs) was assessed by Cytochrome C reduction. The 0 −2 production by nonactivated PMNs in RA patients was significantly higher than in healthy controls. The 0 −2 production by PMNs activated by zymosan and phorbol myristate acetate was significantly lower than in controls. PMNs from controls preincubated with rheumatoid sera generated higher 0 −2 levels than the same PMNs incubated in normal sera.
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Cencetti, A., De Martino, M., Graziani, E. et al. Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis. Clin Rheumatol 9, 51–55 (1990). https://doi.org/10.1007/BF02030242
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DOI: https://doi.org/10.1007/BF02030242