Phytochemical investigation of the roots of Aconitum pseudostapfianum resulted in the isolation of two new C19-diterpenoid alkaloids, designated as pseudostapines A and B (1 and 2). Their structures were determined by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The isolated alkaloids were tested in vivo for antinociceptive potential. The results show that pseudostapines A and B possess more potent antinociceptive effect than the positive control drugs aspirin and acetaminophen.
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Acknowledgment
The above research was made possible by a grant from the joint special fund project of the Applied Basic Research for Local University in Yunnan Province (2019FH001 (-033)), Special funds for reform and development of local university supported by the Central Finance (PL201707230369), and the National Undergraduate Training Programs for Innovation and Entrepreneurship (201910684029).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2022, pp. 270–272.
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Hu, J., Li, J., Li, Q. et al. Antinociceptive Diterpenoid Alkaloids from the Roots of Aconitum pseudostapfianum. Chem Nat Compd 58, 312–315 (2022). https://doi.org/10.1007/s10600-022-03666-1
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DOI: https://doi.org/10.1007/s10600-022-03666-1