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Bibliometric analysis and mini-review of global research on pyroptosis in the field of cancer

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Abstract

Pyroptosis is one of the mechanisms of programmed cell death (PCD) activated by inflammasomes and involved by the caspase family and the gasdermin family. During the oncogenesis and progression of tumors, pyroptosis is crucial, and complex withal. Currently, pyroptosis is the focus topic in the research field of oncology, but there is no single bibliometric analysis systematically studying ‘pyroptosis and cancer’. Our study aimed to visualize the research status of pyroptosis in oncology and excavate the hotspots and prospects in this field. Furthermore, in consideration of the professional direction of researchers, we particularly emphasized articles on pyroptosis in gynecology and formed a mini systematic review. This bibliometric work integrated and analyzed all articles from ISI Web of Science: Science Citation Index Expanded (SCI-Expanded) (dated April 25th, 2022), based on quantitative and visual mapping approaches. Systematically reviewing articles on pyroptosis in gynecology helped us complement our analysis of research advancements in this field. Including 634 articles, our study found that the number of articles on pyroptosis in cancer increased exponentially in recent years. These publications came from 45 countries and regions headed by China and the US mainly aiming at the mechanism of pyroptosis in cell biology and biochemistry molecular biology, as well as the role of pyroptosis in the development and therapeutic application of various cancers. The top 20 most cited studies on this topic mostly came from the US, followed by China and England, and half of the articles cited more than 100 times in total were published in Nature. Moreover, as for gynecologic cancer, in vitro and bioinformatics analysis were the main methodology conducting to explore roles of pyroptosis-related genes (PRGs) and formation of inflammasomes in cancer progression and prognosis. Pyroptosis has evolved into a burgeoning research field in oncology. The cellular and molecular pathway mechanism of pyroptosis, as well as the effect of pyroptosis in oncogenesis, progression, and treatment have been the hot topic of the current study and provided us the future direction as the potential opportunities and challenges. We advocate more active cooperation to improve therapeutic strategies for cancer.

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Data availability

The datasets generated and/or analysed during the current study are available in the Web of Science™ (WOS).

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Acknowledgements

We thank the Web of Science™ (WOS) team for using their data.

Funding

This study was supported in part by the Shanghai Municipal Health Commission (No.201940306); Henan medical science and technology research project (No. 201602031); Key project of provincial and ministerial co-construction of Henan Medical Science and Technology (No. SBGJ202002031). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Author notes

  1. Wenwen Wang, Wenhuizi Sun, Han Xu and Yao Liu  have contributed equally to this work.

Authors and Affiliations

  1. Department of Gynecology, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, 450052, Zhengzhou, China

    Wenwen Wang, Hongjun Guo & Ruixia Guo

  2. Medical Key Laboratory for Prevention and Treatment of Malignant Gynecological Tumor, Henan Province, 450052, Zhengzhou, China

    Wenwen Wang & Ruixia Guo

  3. Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, 200065, Shanghai, China

    Wenhuizi Sun

  4. Department of Obstetrics and Gynecology, East Hospital, School of Medicine, Tongji University, 200120, Shanghai, China

    Han Xu

  5. Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China

    Yao Liu & Hengwei Qin

  6. Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, 450052, Zhengzhou, China

    Chenlu Wei, Penghui Yan, Jiajun Zhang, Jie Lian, Xiangyu Han, Jiaqi Zhang & Zongqiang Huang

  7. Tongji University School of Medicine, 200092, Shanghai, China

    Siqiao Wang, Shuyuan Xian & Jie Zhang

  8. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, 200065, Shanghai, China

    Jie Zhang

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  1. Wenwen Wang
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Contributions

Conception/design by W Wang, W Sun, Z Huang. Collection and/or assembly of data by Y Liu, H Xu S, Wang, S Xian, P Yan, J Zhang, H Guo, H Qin, J Lian, X Han, J Zhang, R Guo, J Zhang. Data analysis and interpretation by W Sun, W Wang, Y Liu, H Xu. Manuscript writing by C Wei, W Sun, Y Liu, H Xu. Final approval of manuscript by S Wang, S Xian, P Yan, J Zhang, H Guo, H Qin, J Lian, X Han, J Zhang, R Guo, J Zhang, Z Huang.

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Correspondence to Yao Liu, Ruixia Guo, Jie Zhang or Zongqiang Huang.

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Wang, W., Sun, W., Xu, H. et al. Bibliometric analysis and mini-review of global research on pyroptosis in the field of cancer. Apoptosis 28, 1076–1089 (2023). https://doi.org/10.1007/s10495-023-01821-9

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