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State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering

  • Additive Manufacturing of Biomaterials, Tissues, and Organs
  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

3D bioprinting is a group of rapidly growing techniques that allows building engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. It enables implementation of various bioinks through different printing mechanisms and precise deposition of cell and/or biomolecule laden biomaterials in predefined locations. This review briefly summarizes applicable bioink materials and various bioprinting techniques, and presents the recent advances in bioprinting of cardiovascular tissues, with focusing on vascularized constructs, myocardium and heart valve conduits. Current challenges and further perspectives are also discussed to help guide the bioink and bioprinter development, improve bioprinting strategies and direct future organ bioprinting and translational applications.

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Acknowledgments

This work has been supported by Mary & Dick Holland Regenerative Medicine Program start-up grant and Nebraska Research Initiative funding. The author has no financial disclosures.

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  1. Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA

    Bin Duan

  2. Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA

    Bin Duan

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Correspondence to Bin Duan.

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Associate Editor Amir Abbas Zadpoor oversaw the review of this article.

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Duan, B. State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering. Ann Biomed Eng 45, 195–209 (2017). https://doi.org/10.1007/s10439-016-1607-5

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