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Preparation of a Poly(2-thiopheneacetic acid) Coating on Magnetite Nanoparticles with One Single Carbon Layer (Fe3O4@1C NPs) for Selective Magnetic Solid-Phase Extraction of Canthin-6-one Alkaloids in Eurycoma longifolia

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Abstract

We present a facile approach for the direct attachment of cross-linked poly(2-thiopheneacetic acid) onto the surface of magnetite nanoparticles with one single carbon layer (Fe3O4@1C NPs) via self-assembly oxidative polymerization. The functional Fe3O4@1C NPs combined with poly(2-thiopheneacetic acid) [Fe3O4@1C@ poly(Th) NPs] was successfully prepared and used for magnetic solid-phase extraction (MSPE). The influence of the preparation conditions and extraction conditions were investigated in detail. The morphology and size distribution of the monolithic materials were characterized by transmission electron microscopy. Under the optimized experimental conditions, the prepared Fe3O4@1C@ poly(Th) NPs showed good extraction efficiency for canthin-6-one alkaloids. Furthermore, the results indicated that the binding specificity and selectivity of the Fe3O4@1C@ poly(Th) NPs might be attributed to electrostatic interactions and pore structure. A MSPE–HPLC method was also developed for quantitative analysis of canthin-6-one alkaloids. The developed method showed good linearity, low limit of detections, low limit of quantifications, and good reproducibility over a wide linear range. To further prove the utility, Fe3O4@1C@ poly(Th) NPs-MSPE was also used to extract canthin-6-one alkaloids from Eurycoma longifolia stems, with a recovery rate of 87.9–114%. Thus, this method is potentially applicable for the extraction of similar alkaloid compounds from medicinal herb samples.

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Abbreviations

ACN:

Acetonitrile

DMF:

Dimethyl formamide

DMSO:

Dimethyl sulfoxide

EF:

Enrichment factor

HPLC:

High-performance liquid chromatography

LOD:

Limit of detection

LOQ:

Limit of quantification

MSPE:

Magnetic solid-phase extraction

SPE:

Solid-phase extraction

RSD:

Relative standard deviation

SDS:

Sodium dodecyl sulfate

SPE:

Solid-phase extraction

TEM:

Transmission electron microscopy

Th:

2-Thiopheneacetic acid

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Acknowledgements

This work was supported by the Natural Science Foundation of Tianjin City, China (Grant numbers 20JCYBJC00070 and 18JCYBJC94700) the Important Drug Development Fund, Ministry of Science and Technology of China (Grant numbers 2018ZX09735-002 and 2019ZX09201005-002-007), and the National Natural Science Foundation (Grant numbers 81803691).

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Author notes

  1. Wang Zhida

    Present address: NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, No.6 North Huanrui Rd, Beichen District, Tianjin, 300134, China

  2. Zixin Zhang and Zhida Wang contributed equally to this work.

Authors and Affiliations

  1. Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China

    Zhang Zixin, Zhang Ying, Zhang Yi, Han Lifeng & Tian Fei

  2. State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China

    Zhang Zixin, Zhang Ying, Zhang Yi, Han Lifeng & Tian Fei

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  1. Zhang Zixin
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Correspondence to Tian Fei.

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Zhang, Z., Wang, Z., Zhang, Y. et al. Preparation of a Poly(2-thiopheneacetic acid) Coating on Magnetite Nanoparticles with One Single Carbon Layer (Fe3O4@1C NPs) for Selective Magnetic Solid-Phase Extraction of Canthin-6-one Alkaloids in Eurycoma longifolia. Chromatographia 84, 1065–1075 (2021). https://doi.org/10.1007/s10337-021-04090-3

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