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Microfluidic Paper-based Analytical Devices in Clinical Applications

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Abstract

Microfluidic paper-based analytical devices (µPADs) take the paper as a base material and integrate nanoscale microchannel on it for multiple detections. Its unique properties like low cost, portability, simple operation, and easy to save make it better than the traditional microfluidic chips. While designed originally for point-of-care medical diagnostics, µPADs have attracted the attention of many researchers in the fields of environmental monitoring, water quality, and food safety. The novelty of this paper is to present a detailed overview of µPADs for clinical applications. Firstly, a brief introduction to production methods, characteristics, and applications of these methods have been given. Secondly, the basic implementation, working principles, and corresponding performance of detection methods of clinical devices have been discussed, which enable the µPADs to detect biomarkers, human cells, bacteria, and viruses in a short time. Lastly, the factors that limit µPADs commercial applications, and their future research directions have also been briefly summarized.

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Funding

This study was funded by the National Natural Science Foundation of China Grant number 31670867 and 31670961, and the Fundamental Research Funds for the Central Universities No.DUT20LAB119.

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Authors and Affiliations

  1. School of Biomedical Engineering, Dalian University of Technology, Liaoning IC&BMES Key Lab, Dalian, 116024, Liaoning, China

    Tingting Han, Yuhang Jin, Chunyang Geng, Aziz ur Rehman Aziz, Sha Deng & Bo Liu

  2. Center for Disease Control and Prevention, Tongzhou, Beijing, 101100, China

    Yang Zhang

  3. Dalian Friendship Hospital, Dalian, 116024, Liaoning, China

    Haijun Ren

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  1. Tingting Han
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  2. Yuhang Jin
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  5. Yang Zhang
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Correspondence to Bo Liu.

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Author Liu declares that he has no conflict of interest; Author Han declares that she has no conflict of interest; Author Jin declares that she has no conflict of interest; Author Geng declares that he has no conflict of interest; Author Aziz declares that he has no conflict of interest; Author Zhang declares that he has no conflict of interest.; Author Deng declares that she has no conflict of interest; Author Ren declares that he has no conflict of interest.

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Han, T., Jin, Y., Geng, C. et al. Microfluidic Paper-based Analytical Devices in Clinical Applications. Chromatographia 83, 693–701 (2020). https://doi.org/10.1007/s10337-020-03892-1

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