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Surgery versus stereotactic radiosurgery for the treatment of multiple meningiomas in neurofibromatosis type 2: illustrative case and systematic review

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Abstract

Neurofibromatosis type 2 (NF2) is a genetic neoplastic disorder that presents with hallmark bilateral vestibular schwannomas and multiple meningiomas. Though the current standard of care for meningiomas includes surgery, the multiplicity of meningiomas in NF2 patients renders complete resection of all developing lesions infeasible. Stereotactic radiosurgery (SRS) may be a viable non-invasive therapeutic alternative to surgery. We describe a particularly challenging case in a 39-year-old male with over 120 lesions who underwent more than 30 surgical procedures, and review the literature. We also searched three popular databases and compared outcomes of SRS versus surgery for the treatment of multiple meningiomas in patients with NF2. A total of 50 patients (27 radiosurgical and 23 surgical) were identified. For patients treated with SRS, local tumor control was achieved in 22 patients (81.5%) and distal control was achieved in 14 patients (51.8%). No malignant inductions were observed at an average follow-up duration of 90 months. Complications in the SRS-treated cohort were reported in 9 patients (33%). Eight patients (29.6%) died due to disease progression. Six patients experienced treatment failure and required further management. For NF2 patients treated with surgery, 11 patients (48%) showed tumor recurrence and 10 patients (43.5%) died due to neurological complications. SRS may be a safe and effective alternative for NF2-associated meningiomas. Further studies are required to identify the ideal radiosurgical candidate.

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Abbreviations

NF2:

Neurofibromatosis type II

NF2-M:

Neurofibromatosis type II-associated meningioma

SRS:

Stereotactic radiosurgery

GKS:

Gamma Knife Surgery

LC:

Local control

References

  1. Adegbite AB, Khan MI, Paine KW, Tan LK (1983) The recurrence of intracranial meningiomas after surgical treatment. J Neurosurg 58:51–56. https://doi.org/10.3171/jns.1983.58.1.0051

    Article  PubMed  CAS  Google Scholar 

  2. Alanin MC, Klausen C, Caye-Thomasen P, Thomsen C, Fugleholm K, Poulsgaard L, Lassen U, Mau-Sorensen M, Hofland KF (2016) Effect of bevacizumab on intracranial meningiomas in patients with neurofibromatosis type 2—a retrospective case series. Int J Neurosci 126:1002–1006. https://doi.org/10.3109/00207454.2015.1092443

    Article  PubMed  CAS  Google Scholar 

  3. Arribas L, Chust ML, Menendez A, Arana E, Vendrell JB, Crispin V, Pesudo C, Mengual JL, Mut A, Arribas M, Guinot JL (2015) Non surgical treatment of vestibular schwannoma. Acta Otorrinolaringol Esp 66:185–191. https://doi.org/10.1016/j.otorri.2014.08.003

    Article  PubMed  Google Scholar 

  4. Asthagiri AR, Parry DM, Butman JA, Kim HJ, Tsilou ET, Zhuang Z, Lonser RR (2009) Neurofibromatosis type 2. Lancet (London, England) 373:1974–1986. doi:https://doi.org/10.1016/S0140-6736(09)60259-2

  5. Barbaro NM, Gutin PH, Wilson CB, Sheline GE, Boldrey EB, Wara WM (1987) Radiation therapy in the treatment of partially resected meningiomas. Neurosurgery 20:525–528

    Article  PubMed  CAS  Google Scholar 

  6. Bari ME, Forster DM, Kemeny AA, Walton L, Hardy D, Anderson JR (2002) Malignancy in a vestibular schwannoma. Report of a case with central neurofibromatosis, treated by both stereotactic radiosurgery and surgical excision, with a review of the literature. Br J Neurosurg 16:284–289

    Article  PubMed  CAS  Google Scholar 

  7. Baser ME, Evans DG, Jackler RK, Sujansky E, Rubenstein A (2000) Neurofibromatosis 2, radiosurgery and malignant nervous system tumours. Br J Cancer 82:998. https://doi.org/10.1054/bjoc.1999.1030

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Baser ME, Friedman JM, Aeschliman D, Joe H, Wallace AJ, Ramsden RT, Evans DG (2002) Predictors of the risk of mortality in neurofibromatosis 2. Am J Hum Genet 71:715–723. https://doi.org/10.1086/342716

    Article  PubMed  PubMed Central  Google Scholar 

  9. Baumgartner JE, Sorenson JM (1996) Meningioma in the pediatric population. J Neuro-Oncol 29:223–228

    Article  CAS  Google Scholar 

  10. Birckhead B, Sio TT, Pollock BE, Link MJ, Laack NN (2016) Gamma Knife radiosurgery for neurofibromatosis type 2-associated meningiomas: a 22-year patient series. J Neuro-Oncol 130:553–560. https://doi.org/10.1007/s11060-016-2257-z

    Article  CAS  Google Scholar 

  11. Black PM (1991) Brain tumors. Part 1. N Engl J Med 324:1471–1476. https://doi.org/10.1056/NEJM199105233242105

    Article  PubMed  CAS  Google Scholar 

  12. Black PM (1991) Brain tumors. Part 2. N Engl J Med 324:1555–1564. https://doi.org/10.1056/NEJM199105303242205

    Article  PubMed  CAS  Google Scholar 

  13. Bush ML, Oblinger J, Brendel V, Santarelli G, Huang J, Akhmametyeva EM, Burns SS, Wheeler J, Davis J, Yates CW, Chaudhury AR, Kulp S, Chen CS, Chang LS, Welling DB, Jacob A (2011) AR42, a novel histone deacetylase inhibitor, as a potential therapy for vestibular schwannomas and meningiomas. Neuro-Oncology 13:983–999. https://doi.org/10.1093/neuonc/nor072

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Carlson ML, Babovic-Vuksanovic D, Messiaen L, Scheithauer BW, Neff BA, Link MJ (2010) Radiation-induced rhabdomyosarcoma of the brainstem in a patient with neurofibromatosis type 2. J Neurosurg 112:81–87. https://doi.org/10.3171/2009.6.jns09105

    Article  PubMed  Google Scholar 

  15. Condra KS, Buatti JM, Mendenhall WM, Friedman WA, Marcus RB Jr, Rhoton AL (1997) Benign meningiomas: primary treatment selection affects survival. Int J Radiat Oncol Biol Phys 39:427–436

    Article  PubMed  CAS  Google Scholar 

  16. Dirks MS, Butman JA, Kim HJ, Wu T, Morgan K, Tran AP, Lonser RR, Asthagiri AR (2012) Long-term natural history of neurofibromatosis type 2-associated intracranial tumors. J Neurosurg 117:109–117. https://doi.org/10.3171/2012.3.JNS111649

    Article  PubMed  PubMed Central  Google Scholar 

  17. Evans DG (2009) Neurofibromatosis type 2 (NF2): a clinical and molecular review. Orphanet J Rare Dis 4:16. https://doi.org/10.1186/1750-1172-4-16

    Article  PubMed  PubMed Central  Google Scholar 

  18. Evans DG, Birch JM, Ramsden RT, Sharif S, Baser ME (2006) Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes. J Med Genet 43:289–294. https://doi.org/10.1136/jmg.2005.036319

    Article  PubMed  CAS  Google Scholar 

  19. Evans DG, Huson SM, Donnai D, Neary W, Blair V, Newton V, Harris R (1992) A clinical study of type 2 neurofibromatosis. Q J Med 84:603–618

    PubMed  CAS  Google Scholar 

  20. Evans DG, Moran A, King A, Saeed S, Gurusinghe N, Ramsden R (2005) Incidence of vestibular schwannoma and neurofibromatosis 2 in the North West of England over a 10-year period: higher incidence than previously thought. Otol Neurotol 26:93–97

    Article  PubMed  Google Scholar 

  21. Flickinger JC, Kondziolka D, Maitz AH, Lunsford LD (2003) Gamma Knife radiosurgery of imaging-diagnosed intracranial meningioma. Int J Radiat Oncol Biol Phys 56:801–806

    Article  PubMed  Google Scholar 

  22. Gao X, Zhang R, Mao Y, Wang Y (2009) Childhood and juvenile meningiomas. Childs Nerv Syst 25:1571–1580. https://doi.org/10.1007/s00381-009-0964-x

    Article  PubMed  Google Scholar 

  23. Glasier CM, Husain MM, Chadduck W, Boop FA (1993) Meningiomas in children: MR and histopathologic findings. AJNR Am J Neuroradiol 14:237–241

    PubMed  CAS  Google Scholar 

  24. Goutagny S, Bah AB, Henin D, Parfait B, Grayeli AB, Sterkers O, Kalamarides M (2012) Long-term follow-up of 287 meningiomas in neurofibromatosis type 2 patients: clinical, radiological, and molecular features. Neuro-Oncology 14:1090–1096. https://doi.org/10.1093/neuonc/nos129

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. Graillon T, Defilles C, Mohamed A, Lisbonis C, Germanetti AL, Chinot O, Figarella-Branger D, Roche PH, Adetchessi T, Fuentes S, Metellus P, Dufour H, Enjalbert A, Barlier A (2015) Combined treatment by octreotide and everolimus: octreotide enhances inhibitory effect of everolimus in aggressive meningiomas. J Neuro-Oncol 124:33–43. https://doi.org/10.1007/s11060-015-1812-3

    Article  CAS  Google Scholar 

  26. Greene S, Nair N, Ojemann JG, Ellenbogen RG, Avellino AM (2008) Meningiomas in children. Pediatr Neurosurg 44:9–13. https://doi.org/10.1159/000110656

    Article  PubMed  Google Scholar 

  27. Hakim R, Alexander E 3rd, Loeffler JS, Shrieve DC, Wen P, Fallon MP, Stieg PE, Black PM (1998) Results of linear accelerator-based radiosurgery for intracranial meningiomas. Neurosurgery 42:446–453 discussion 453-444

    Article  PubMed  CAS  Google Scholar 

  28. Ho SY, Kveton JF (2002) Rapid growth of acoustic neuromas after stereotactic radiotherapy in type 2 neurofibromatosis. Ear, nose, & throat journal 81:831–833

    Article  Google Scholar 

  29. Im SH, Wang KC, Kim SK, Oh CW, Kim DG, Hong SK, Kim NR, Chi JG, Cho BK (2001) Childhood meningioma: unusual location, atypical radiological findings, and favorable treatment outcome. Childs Nerv Syst 17:656–662. https://doi.org/10.1007/s003810100507

    Article  PubMed  CAS  Google Scholar 

  30. Jacob JT, Link MJ, Pollock BE (2014) Role of stereotactic radiosurgery in meningiomas and vestibular schwannomas. Curr Treat Options Neurol 16:308. https://doi.org/10.1007/s11940-014-0308-3

    Article  PubMed  Google Scholar 

  31. Kim BS, Seol HJ, Lee JI, Shin HJ, Park K, Kong DS, Nam DH, Cho YS (2016) Clinical outcome of neurofibromatosis type 2-related vestibular schwannoma: treatment strategies and challenges. Neurosurg Rev 39:643–653. https://doi.org/10.1007/s10143-016-0728-5

    Article  PubMed  Google Scholar 

  32. Kollova A, Liscak R, Novotny J Jr, Vladyka V, Simonova G, Janouskova L (2007) Gamma Knife surgery for benign meningioma. J Neurosurg 107:325–336. https://doi.org/10.3171/jns-07/08/0325

    Article  PubMed  Google Scholar 

  33. Kondziolka D, Flickinger JC, Perez B (1998) Judicious resection and/or radiosurgery for parasagittal meningiomas: outcomes from a multicenter review. Gamma Knife Meningioma Study Group Neurosurgery 43:405–413 discussion 413-404

    CAS  Google Scholar 

  34. Kondziolka D, Levy EI, Niranjan A, Flickinger JC, Lunsford LD (1999) Long-term outcomes after meningioma radiosurgery: physician and patient perspectives. J Neurosurg 91:44–50. https://doi.org/10.3171/jns.1999.91.1.0044

    Article  PubMed  CAS  Google Scholar 

  35. Kondziolka D, Mathieu D, Lunsford LD, Martin JJ, Madhok R, Niranjan A, Flickinger JC (2008) Radiosurgery as definitive management of intracranial meningiomas. Neurosurgery 62:53–58; discussion 58-60. https://doi.org/10.1227/01.NEU.0000311061.72626.0D

    Article  PubMed  Google Scholar 

  36. Kotapka MJ, Kalia KK, Martinez AJ, Sekhar LN (1994) Infiltration of the carotid artery by cavernous sinus meningioma. J Neurosurg 81:252–255. https://doi.org/10.3171/jns.1994.81.2.0252

    Article  PubMed  CAS  Google Scholar 

  37. Larson JJ, van Loveren HR, Balko MG, Tew JM Jr (1995) Evidence of meningioma infiltration into cranial nerves: clinical implications for cavernous sinus meningiomas. J Neurosurg 83:596–599. https://doi.org/10.3171/jns.1995.83.4.0596

    Article  PubMed  CAS  Google Scholar 

  38. Lee HH, Lian SL, Huang CJ, Huang MY (2010) Tomotherapy for neurofibromatosis type 2: case report and review of the literature. Br J Radiol 83:e74–e78. https://doi.org/10.1259/bjr/16531514

    Article  PubMed  Google Scholar 

  39. Lee JY, Niranjan A, McInerney J, Kondziolka D, Flickinger JC, Lunsford LD (2002) Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomas. J Neurosurg 97:65–72. https://doi.org/10.3171/jns.2002.97.1.0065

    Article  PubMed  Google Scholar 

  40. Rogers L, Barani I, Chamberlain M, Kaley TJ, McDermott M, Raizer J, Schiff D, Weber DC, Wen PY, Vogelbaum MA (2015) Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg 122:4–23. https://doi.org/10.3171/2014.7.jns131644

    Article  PubMed  PubMed Central  Google Scholar 

  41. Liscak R, Kollova A, Vladyka V, Simonova G, Novotny J Jr (2004) Gamma Knife radiosurgery of skull base meningiomas. Acta Neurochir Suppl 91:65–74

    PubMed  CAS  Google Scholar 

  42. Liscak R, Simonova G, Vymazal J, Janouskova L, Vladyka V (1999) Gamma Knife radiosurgery of meningiomas in the cavernous sinus region. Acta Neurochir 141:473–480

    Article  PubMed  CAS  Google Scholar 

  43. Liu A, Kuhn EN, Lucas JT Jr, Laxton AW, Tatter SB, Chan MD (2015) Gamma Knife radiosurgery for meningiomas in patients with neurofibromatosis type 2. J Neurosurg 122:536–542. https://doi.org/10.3171/2014.10.JNS132593

    Article  PubMed  Google Scholar 

  44. Lund-Johansen M, Scheie D, Muller T, Lundar T, Helseth E (2001) Neurosurgical treatment of meningiomas in children and young adults. Childs Nerv Syst 17:719–723. https://doi.org/10.1007/s00381-001-0516-5

    Article  PubMed  CAS  Google Scholar 

  45. Mallory GW, Pollock BE, Foote RL, Carlson ML, Driscoll CL, Link MJ (2014) Stereotactic radiosurgery for neurofibromatosis 2-associated vestibular schwannomas: toward dose optimization for tumor control and functional outcomes. Neurosurgery 74:292–300; discussion 300-291. https://doi.org/10.1227/neu.0000000000000264

    Article  PubMed  Google Scholar 

  46. Mathiesen T, Lindquist C, Kihlstrom L, Karlsson B (1996) Recurrence of cranial base meningiomas. Neurosurgery 39:2–7 discussion 8-9

    Article  PubMed  CAS  Google Scholar 

  47. Mautner VF, Lindenau M, Baser ME, Hazim W, Tatagiba M, Haase W, Samii M, Wais R, Pulst SM (1996) The neuroimaging and clinical spectrum of neurofibromatosis 2. Neurosurgery 38:880–885 discussion 885-886

    Article  PubMed  CAS  Google Scholar 

  48. McEvoy AW, Kitchen ND (2003) Rapid enlargement of a vestibular schwannoma following Gamma Knife treatment. Minimally invasive neurosurgery : MIN 46:254–256. https://doi.org/10.1055/s-2003-42347

    Article  PubMed  CAS  Google Scholar 

  49. Mirimanoff RO (2004) New radiotherapy technologies for meningiomas: 3D conformal radiotherapy? Radiosurgery? Stereotactic radiotherapy? Intensity-modulated radiotherapy? Proton beam radiotherapy? Spot scanning proton radiation therapy. . . or nothing at all? Radiother Oncol 71:247–249. doi:https://doi.org/10.1016/j.radonc.2004.05.002

  50. Muthukumar N, Kondziolka D, Lunsford LD, Flickinger JC (1998) Stereotactic radiosurgery for tentorial meningiomas. Acta Neurochir 140:315–320 discussion 320-311

    Article  PubMed  CAS  Google Scholar 

  51. Muthukumar N, Kondziolka D, Lunsford LD, Flickinger JC (1999) Stereotactic radiosurgery for anterior foramen magnum meningiomas. Surg Neurol 51:268–273

    Article  PubMed  CAS  Google Scholar 

  52. Nakasu S, Fukami T, Nakajima M, Watanabe K, Ichikawa M, Matsuda M (2005) Growth pattern changes of meningiomas: long-term analysis. Neurosurgery 56:946–955 discussion 946-955

    PubMed  Google Scholar 

  53. Noren G (1998) Long-term complications following Gamma Knife radiosurgery of vestibular schwannomas. Stereotact Funct Neurosurg 70(Suppl 1):65–73

    Article  PubMed  Google Scholar 

  54. Olivero WC, Lister JR, Elwood PW (1995) The natural history and growth rate of asymptomatic meningiomas: a review of 60 patients. J Neurosurg 83:222–224. https://doi.org/10.3171/jns.1995.83.2.0222

    Article  PubMed  CAS  Google Scholar 

  55. Parry DM, Eldridge R, Kaiser-Kupfer MI, Bouzas EA, Pikus A, Patronas N (1994) Neurofibromatosis 2 (NF2): clinical characteristics of 63 affected individuals and clinical evidence for heterogeneity. Am J Med Genet 52:450–461. https://doi.org/10.1002/ajmg.1320520411

    Article  PubMed  CAS  Google Scholar 

  56. Patil CG, Hoang S, Borchers DJ 3rd, Sakamoto G, Soltys SG, Gibbs IC, Harsh GR, Chang SD, Adler JR Jr (2008) Predictors of peritumoral edema after stereotactic radiosurgery of supratentorial meningiomas. Neurosurgery 63:435–440; discussion 440-432. https://doi.org/10.1227/01.NEU.0000325257.58684.92

    Article  PubMed  Google Scholar 

  57. Patronas NJ, Courcoutsakis N, Bromley CM, Katzman GL, MacCollin M, Parry DM (2001) Intramedullary and spinal canal tumors in patients with neurofibromatosis 2: MR imaging findings and correlation with genotype. Radiology 218:434–442. https://doi.org/10.1148/radiology.218.2.r01fe40434

    Article  PubMed  CAS  Google Scholar 

  58. Pendl G, Eustacchio S, Unger F (2001) Radiosurgery as alternative treatment for skull base meningiomas. J Clin Neurosci 8(Suppl 1):12–14. https://doi.org/10.1054/jocn.2001.0869

    Article  PubMed  Google Scholar 

  59. Perry A, Giannini C, Raghavan R, Scheithauer BW, Banerjee R, Margraf L, Bowers DC, Lytle RA, Newsham IF, Gutmann DH (2001) Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases. J Neuropathol Exp Neurol 60:994–1003

    Article  PubMed  CAS  Google Scholar 

  60. Pollock BE, Stafford SL, Utter A, Giannini C, Schreiner SA (2003) Stereotactic radiosurgery provides equivalent tumor control to Simpson grade 1 resection for patients with small- to medium-size meningiomas. Int J Radiat Oncol Biol Phys 55:1000–1005

    Article  PubMed  Google Scholar 

  61. Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol 5:1045–1054. https://doi.org/10.1016/s1474-4422(06)70625-1

    Article  PubMed  CAS  Google Scholar 

  62. Rochat P, Johannesen HH, Gjerris F (2004) Long-term follow up of children with meningiomas in Denmark: 1935 to 1984. J Neurosurg 100:179–182. https://doi.org/10.3171/ped.2004.100.2.0179

    Article  PubMed  Google Scholar 

  63. Rowe J, Radatz M, Kemeny A (2008) Radiosurgery for type II neurofibromatosis. Prog Neurol Surg 21:176–182. https://doi.org/10.1159/000156907

    Article  PubMed  Google Scholar 

  64. Santacroce A, Walier M, Regis J, Liscak R, Motti E, Lindquist C, Kemeny A, Kitz K, Lippitz B, Martinez Alvarez R, Pedersen PH, Yomo S, Lupidi F, Dominikus K, Blackburn P, Mindermann T, Bundschuh O, van Eck AT, Fimmers R, Horstmann GA (2012) Long-term tumor control of benign intracranial meningiomas after radiosurgery in a series of 4565 patients. Neurosurgery 70:32–39; discussion 39. https://doi.org/10.1227/NEU.0b013e31822d408a

    Article  PubMed  Google Scholar 

  65. Sheikh BY, Siqueira E, Dayel F (1996) Meningioma in children: a report of nine cases and a review of the literature. Surg Neurol 45:328–335

    Article  PubMed  CAS  Google Scholar 

  66. Smee RI, Schneider M, Williams JR (2009) Optic nerve sheath meningiomas—non-surgical treatment. Clin Oncol (R Coll Radiol) 21:8–13. https://doi.org/10.1016/j.clon.2008.10.010

    Article  CAS  Google Scholar 

  67. Soria JC, Gan HK, Blagden SP, Plummer R, Arkenau HT, Ranson M, Evans TR, Zalcman G, Bahleda R, Hollebecque A, Lemech C, Dean E, Brown J, Gibson D, Peddareddigari V, Murray S, Nebot N, Mazumdar J, Swartz L, Auger KR, Fleming RA, Singh R, Millward M (2016) A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors. Ann Oncol 27:2268–2274. https://doi.org/10.1093/annonc/mdw427

    Article  PubMed  CAS  Google Scholar 

  68. Spatola G, Carron R, Delsanti C, Thomassin JM, Roche PH, Regis J (2016) Long-term results of Gamma-Knife stereotactic radiosurgery for vestibular schwannomas in patients with type 2 neurofibromatosis. Neurochirurgie. https://doi.org/10.1016/j.neuchi.2016.03.005

  69. Stachowicz-Stencel T, Synakiewicz A, Bien E, Adamkiewicz-Drozynska E, Wybieralska-Dubaniewicz M, Balcerska A (2011) Multiple primary cranio-spinal tumours in a 13-year-old female with neurofibromatosis type 2 management strategy. Childs Nerv Syst 27:175–178. https://doi.org/10.1007/s00381-010-1238-3

    Article  PubMed  Google Scholar 

  70. Stafford SL, Perry A, Suman VJ, Meyer FB, Scheithauer BW, Lohse CM, Shaw EG (1998) Primarily resected meningiomas: outcome and prognostic factors in 581 Mayo Clinic patients, 1978 through 1988. Mayo Clin Proc 73:936–942. https://doi.org/10.4065/73.10.936

    Article  PubMed  CAS  Google Scholar 

  71. Stanuszek A, Piatek P, Kwiatkowski S, Adamek D (2014) Multiple faces of children and juvenile meningiomas: a report of single-center experience and review of literature. Clin Neurol Neurosurg 118:69–75. https://doi.org/10.1016/j.clineuro.2013.12.019

    Article  PubMed  Google Scholar 

  72. Subach BR, Lunsford LD, Kondziolka D, Maitz AH, Flickinger JC (1998) Management of petroclival meningiomas by stereotactic radiosurgery. Neurosurgery 42:437–443 discussion 443-435

    Article  PubMed  CAS  Google Scholar 

  73. Tanbouzi Husseini S, Piccirillo E, Taibah A, Paties CT, Rizzoli R, Sanna M (2011) Malignancy in vestibular schwannoma after stereotactic radiotherapy: a case report and review of the literature. Laryngoscope 121:923–928. https://doi.org/10.1002/lary.21448

    Article  PubMed  Google Scholar 

  74. Thomsen J, Mirz F, Wetke R, Astrup J, Bojsen-Moller M, Nielsen E (2000) Intracranial sarcoma in a patient with neurofibromatosis type 2 treated with Gamma Knife radiosurgery for vestibular schwannoma. Am J Otol 21:364–370

    Article  PubMed  CAS  Google Scholar 

  75. Tufan K, Dogulu F, Kurt G, Emmez H, Ceviker N, Baykaner MK (2005) Intracranial meningiomas of childhood and adolescence. Pediatr Neurosurg 41:1–7. https://doi.org/10.1159/000084858

    Article  PubMed  Google Scholar 

  76. Vermeulen S, Young R, Li F, Meier R, Raisis J, Klein S, Kohler E (1999) A comparison of single fraction radiosurgery tumor control and toxicity in the treatment of basal and nonbasal meningiomas. Stereotact Funct Neurosurg 72 Suppl 1:60-66. Doi:56440

  77. Villavicencio AT, Black PM, Shrieve DC, Fallon MP, Alexander E, Loeffler JS (2001) Linac radiosurgery for skull base meningiomas. Acta Neurochir 143:1141–1152. https://doi.org/10.1007/s007010100005

    Article  PubMed  CAS  Google Scholar 

  78. Walter J, Kuhn SA, Brodhun M, Reichart R, Kalff R (2009) Pulmonary meningioma and neurinoma associated with multiple CNS tumours in a patient with neurofibromatosis type 2. Clin Neurol Neurosurg 111:454–459. https://doi.org/10.1016/j.clineuro.2008.11.018

    Article  PubMed  Google Scholar 

  79. Yoneoka Y, Fujii Y, Tanaka R (2000) Growth of incidental meningiomas. Acta Neurochir 142:507–511. https://doi.org/10.1007/s007010050463

    Article  PubMed  CAS  Google Scholar 

  80. Zwerdling T, Dothage J (2002) Meningiomas in children and adolescents. J Pediatr Hematol Oncol 24:199–204

    Article  PubMed  Google Scholar 

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Funding information

Thien Nguyen and John P. Sheppard are recipients of the David Geffen Medical Scholarship. Dr. Isaac Yang reports being supported by the UCLA Visionary Ball Fund Grant, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research UCLA Scholars in Translational Medicine Program Award, Jason Dessel Memorial Seed Grant, UCLA Honberger Endowment Brain Tumor Research Seed Grant, and Stop Cancer (US) Development Award. The sponsors had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Department of Neurosurgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA

    Thien Nguyen, Lawrance K. Chung, John P. Sheppard, Nikhilesh S. Bhatt, Cheng Hao Jacky Chen, Carlito Lagman, Tania Kaprealian & Isaac Yang

  2. Department of Radiation Oncology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA

    Tania Kaprealian, Percy Lee & Isaac Yang

  3. Department of Head and Neck Surgery, David Geffen School of Medicine, University of California- Los Angeles, Los Angeles, CA, USA

    Tania Kaprealian & Isaac Yang

  4. Department of Neurology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA

    Phioanh L. Nghiemphu

  5. Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA

    Phioanh L. Nghiemphu & Isaac Yang

  6. Los Angeles Biomedical Research Institute, University of California-Los Angeles, Los Angeles, CA, USA

    Isaac Yang

  7. Harbor-UCLA Medical Center, University of California-Los Angeles, Los Angeles, CA, USA

    Isaac Yang

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  1. Thien Nguyen
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Correspondence to Isaac Yang.

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Dr. Isaac Yang is a consultant for BrainLab. All other authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required. This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Nguyen, T., Chung, L.K., Sheppard, J.P. et al. Surgery versus stereotactic radiosurgery for the treatment of multiple meningiomas in neurofibromatosis type 2: illustrative case and systematic review. Neurosurg Rev 42, 85–96 (2019). https://doi.org/10.1007/s10143-017-0904-2

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  • DOI: https://doi.org/10.1007/s10143-017-0904-2

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