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Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis.

Materials and methods

Using specific keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle–Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. ReVman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference (MD) and 95% confidence interval (95% CI). The heterogeneity test was conducted according to I2 and Q tests. Egger’s test was used to quantitatively evaluate publication bias.

Results

This analysis involved 12 studies (12,395 subjects). The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC) (MD = 0.11 mmol/L, 95%CI: − 0.03, 0.25; I2 = 21%; P = 0.36), triglycerides (TG) (MD =  − 0.01 mmol/L, 95%CI: − 0.09, 0.07; I2 = 6%; P = 0.34), and low-density lipoprotein cholesterol (LDL-C) (MD = 0.10 mmol/L, 95%CI: 0.00, 0.19; I2 = 0%; P = 0.74) in the osteopenia were not significantly increased/decreased. There were no significant differences in LDL-C (MD = 0.02 mmol/L, 95%CI: − 0.09, 0.13; I2 = 0%; P = 0.74) in postmenopausal women in osteopenia. TG (MD =  − 0.04 mmol/L, 95%CI: − 0.14,0.07; I2 = 49%; P = 0.07) was unchanged in the osteoporosis (OP) group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group (MD = 0.05 mmol/L, 95%CI: 0.03, 0.07; I2 = 31%; P = 0.15) but not in osteopenia group (MD = 0.01 mmol/L, 95%CI: − 0.01, 0.02; I2 = 38%; P = 0.14) in all subjects.

Conclusion

HDL-C was elevated in patients with OP.

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Availability of data and material

The original data can be obtained by email request.

Abbreviations

BMD:

Bone mineral density

BMI:

Body mass index

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

MD:

Mean difference

TC:

Total cholesterol

TG:

Triglyceride

OP:

Osteoporosis

95%CI:

95% Confidence interval

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Acknowledgements

We thank Melissa Crawford, PhD, from Liwen Bianji, Edanz Editing China (www.liwenbianji.cn/ac), for editing the English text of a draft of this manuscript.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Endocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, 050051, Hebei, China

    Hang Zhao & Yong Tang

  2. North China University of Science and Technology, 21, Bohai Avenue, Caofeidian New Town, Tangshan, 063210, Hebei, China

    Yong Li

  3. Graduate School of Hebei Medical University, 361, Zhongshan East Road, Shijiazhuang, 050017, Hebei, China

    Miaomiao Zhang

  4. Graduate School of Hebei North University, 11, South Diamond Road, GaoXin District, Zhangjiakou, 075000, Hebei, China

    Licui Qi

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  1. Hang Zhao
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Contributions

HZ: Conceptualization, Methodology, Writing—original draft. YL, MZ and LQ: Methodology, Software. YT: Conceptualization, Writing—review and editing. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yong Tang.

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All other authors have no conflicts of interest.

Ethics approval

All analyses were based on previous published studies, thus no ethical approval and patient consent are required.

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Informed consent was obtained from all individual participants included in the study.

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This manuscript has been approved by all co-authors and has not been published before.

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Zhao, H., Li, Y., Zhang, M. et al. Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis. J Bone Miner Metab 39, 510–520 (2021). https://doi.org/10.1007/s00774-020-01189-9

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  • DOI: https://doi.org/10.1007/s00774-020-01189-9

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