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Impact of cytomegalovirus load on host response to sepsis

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Abstract

There is a decades old association between cytomegalovirus reactivation and sepsis in immune-competent hosts. Much has been learned about this relationship, which has been described as bidirectional, meaning that the virus incites and is incited by the host’s inflammatory response. More recent work has suggested that chronic viral infection leaves the host with exaggerated immunity to bacterial infections. In this review, the relationship between CMV and host responses to sepsis are reviewed, with particular attention to the impact that tissue viral load contributes to this phenomenon.

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  1. Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St, Lowry 2G, Boston, MA, 02215, USA

    Thomas Marandu, Michael Dombek & Charles H. Cook

  2. University of Dar Es Salaam, Mbeya College of Health and Allied Sciences, Mbeya, Tanzania

    Thomas Marandu

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This article is part of the Special Issue on Immunological Imprinting during Chronic Viral Infection.

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Marandu, T., Dombek, M. & Cook, C.H. Impact of cytomegalovirus load on host response to sepsis. Med Microbiol Immunol 208, 295–303 (2019). https://doi.org/10.1007/s00430-019-00603-y

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