Abstract
Despite the importance of cigarette smoking as a cause of respiratory symptoms and disease, until recently there has been little attention on the effect of smoking on cough reflex sensitivity. Recent studies have shown that in otherwise healthy smokers, cough reflex sensitivity is diminished relative to that of nonsmokers. One proposed mechanism, chronic cigarette smoke-induced desensitization of airway cough receptors, is supported by the demonstration that smoking cessation leads to prompt enhancement of cough reflex sensitivity, even after many years of smoking. Furthermore, resumption of cigarette smoking promptly results in suppression of cough reflex sensitivity. These observations have introduced the concept that cough reflex sensitivity in humans is a dynamic phenomenon, able to be modulated by the presence or absence of stimuli such as cigarette smoke, even after prolonged exposure.
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References
French CT, Irwin RS, Fletcher KE, Adams TM (2002) Evaluation of a cough-specific quality-of-life questionnaire. Chest 121:1123–1131
Groneberg-Kloft B, Feleszko W, Dinh QT, van Mark A, Brinkmann E, Pleimes D, Fischer A (2007) Analysis and evaluation of environmental tobacco smoke exposure as a risk factor for chronic cough. Cough 3:1–6
Zemp E, Elsasser S, Schindler C, Kunzil N, Perruchoud AP, Domenighetti G, Medici T, Ackerman-Liebrich U, Leuenberger P, Monn C, Bolognini G, Bongard JP, Brandli O, Karrer W, Keller R, Schoni MH, Tschopp JM, Villiger B, Zellweger JP (1999) Long-term ambient air pollution and respiratory symptoms in adults (SAPALDIA study). Am J Respir Crit Care Med 159:1257–1266
Carr MJ, Lee L-Y (2006) Plasticity of peripheral mechanisms of cough. Respir Physiol Neurobiol 152:298–311
Millqvist E, Bende M (2001) Capsaicin cough sensitivity is decreased in smokers. Respir Med 95:19–21
Dicpinigaitis PV (2003) Cough reflex sensitivity in cigarette smokers. Chest 123:685–688
Dicpinigaitis PV (2006) Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Chest 129(Suppl):169S–173S
Carr MJ (2004) Plasticity of vagal afferent fibres mediating cough. Pulm Pharmacol Ther 17:447–451
Blanc F-X, Macedo P, Hew M, Chung KF (2009) Capsaicin cough sensitivity in smokers with and without airflow obstruction. Respir Med 103:786–790
Dicpinigaitis PV, Sitkauskiene B (2009) Letter to the editor regarding: Blanc F-X, et al. “Capsaicin cough sensitivity in smokers with and without airflow obstruction”. Respir Med 103:1242–1243
Morice AH, Fontana GA, Belvisi MG, Birring SS, Chung KF, Dicpinigaitis PV, Kastelik JA, McGarvey LP, Smith JA, Tatar M, Widdicombe J (2007) ERS guidelines on the assessment of cough. Eur Respir J 29:1256–1276
Arcavi L, Benowitz NL (2004) Cigarette smoking and infection. Arch Intern Med 164:2206–2216
Dicpinigaitis PV, Sitkauskiene B, Stravinskaite K, Appel DW, Negassa A, Sakalauskas R (2006) Effect of smoking cessation on cough reflex sensitivity. Eur Respir J 28:786–790
Cummings KM, Giovino G, Jaen CR, Emrich LJ (1985) Reports of smoking withdrawal symptoms over a 21-day period of abstinence. Addict Behav 10:373–381
Sitkauskiene B, Stravinskaite K, Sakalauskas R, Dicpinigaitis PV (2007) Changes in cough reflex sensitivity after cessation and resumption of cigarette smoking. Pulm Pharmacol Ther 20:240–243
Wood AM, Stockley RA (2006) The genetics of chronic obstructive pulmonary disease. Respir Res 7:130
Stravinskaite K, Sitkauskiene B, Dicpinigaitis PV, Babusyte A, Sakalauskas R (2009) Influence of smoking status on cough reflex sensitivity in subjects with COPD. Lung 187:37–42
Doherty MJ, Mister R, Pearson MG, Calverley PMA (2000) Capsaicin responsiveness and cough in asthma and chronic obstructive pulmonary disease. Thorax 55:643–649
Dicpinigaitis PV (2001) Capsaicin responsiveness in asthma and COPD. Thorax 56:161
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Sitkauskiene, B., Dicpinigaitis, P.V. Effect of Smoking on Cough Reflex Sensitivity in Humans. Lung 188 (Suppl 1), 29–32 (2010). https://doi.org/10.1007/s00408-009-9188-9
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DOI: https://doi.org/10.1007/s00408-009-9188-9