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Modification and preparation of four natural hydrogels and their application in biopharmaceutical delivery

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Abstract

Hydrogels possess a unique three-dimensional structure into which many drugs can be incorporated. The hydrogels slow down the release rate of drugs, protect them from external factors and improve their stability. Thus, hydrogels have been widely used in delivering biological products in recent years. The characteristics of natural hydrogel materials are low toxicity, easily accessible and sufficient resources. After modification, natural hydrogels can be more ductile and avoid the defects of brittle quality. Chemical modification of the groups in natural hydrogels improves some of their sensitivity toward pH, temperature and light. Chitosan, hyaluronic acid, gelatin, and sodium alginate are four common natural polymers widely used in medicine and health care. A systematic review of the above four polymer materials is essential for an in-depth understanding of their functions and further development. This review summarizes (1) the characteristics of chitosan, hyaluronic acid, gelatin and sodium alginate these four polymers, (2) their derivatives and mechanisms, (3) the crosslinking mechanisms, and (4) the applications in the delivery of biological products. This review will be a comprehensive resource on these polymers and will be helpful to the researchers who are interested in developing drug delivery systems.

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Acknowledgements

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Authors and Affiliations

  1. College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China

    He Mengyuan, Wang Changlin, Xu Tong, Dong Ping, Yu Xiaojun, Song Huaying, Liu Congying, Gao Peng & Cong Zhufeng

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  1. He Mengyuan
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  2. Wang Changlin
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  3. Xu Tong
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  4. Dong Ping
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  5. Yu Xiaojun
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  6. Song Huaying
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  7. Liu Congying
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  8. Gao Peng
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  9. Cong Zhufeng
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Contributions

All authors contributed to the study's conception and design. Xu Tong and Dong Ping performed material preparation, data collection, and analysis. The drawing of the picture was completed by Yu Xiaojun Song Huaying and Liu Congying. The first draft of the manuscript was written by He Mengyuan. The suggestion on the structure of the article was revised by Wang Changlin. The last part of the article is revised by Gao Peng and Cong Zhufeng and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Gao Peng or Cong Zhufeng.

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Mengyuan, H., Changlin, W., Tong, X. et al. Modification and preparation of four natural hydrogels and their application in biopharmaceutical delivery. Polym. Bull. 80, 7101–7144 (2023). https://doi.org/10.1007/s00289-022-04412-x

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  • DOI: https://doi.org/10.1007/s00289-022-04412-x

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