Abstract
This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew’s ear (black) fungus or black wood ear fungus Auricularia auricula–judae, reishi mushroom or Lingzhi Ganoderma lucidum, Ganoderma sinense, maitake mushroom or sheep’s head mushroom Grifola frondosa, lion’s mane mushroom or monkey head mushroom Hericium erinaceum, brown beech mushroom Hypsizigus marmoreus, sulfur polypore mushroom Laetiporus sulphureus, Lentinula edodes (shiitake mushroom), Phellinus linteus (Japanese “meshimakobu,” Chinese “song gen,” Korean “sanghwang,” American “black hoof mushroom”), abalone mushroom Pleurotus abalonus, king oyster mushroom Pleurotus eryngii, oyster mushroom Pleurotus ostreatus, tuckahoe or Fu Ling Poria cocos, and split gill mushroom Schizophyllum commune. Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.
We’re sorry, something doesn't seem to be working properly.
Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.
References
Acevedo-Díaz A, Ortiz-Soto G, Suárez-Arroyo IJ, Zayas-Santiago A, Martínez Montemayor MM (2019) Ganoderma lucidum extract reduces the motility of breast cancer cells mediated by the RAC-lamellipodin axis. Nutrients 11(5):E1116. https://doi.org/10.3390/nu11051116
Alonso EN, Orozco M, Eloy Nieto A, Balogh GA (2013) Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells. J Med Food 16(7):602–617. https://doi.org/10.1089/jmf.2012.0222
Alonso EN, Ferronato MJ, Gandini NA, Fermento ME, Obiol DJ, López Romero A, Arévalo J, Villegas ME, Facchinetti MM, Curino AC (2017) Antitumoral effects of D-fraction from Grifola Frondosa (maitake) mushroom in breast cancer. Nutr Cancer 69(1):29–43. https://doi.org/10.1080/01635581.2017.1247891
Alonso EN, Ferronato MJ, Fermento ME, Gandini NA, Romero AL, Guevara JA, Facchinetti MM, Curino AC (2018) Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells. Oncotarget 9(34):23396–23412. https://doi.org/10.18632/oncotarget.25174
Aoyagi H, Iino Y, Takeo T, Horii Y, Morishita Y, Horiuchi R (1997) Effects of OK-432 (picibanil) on the estrogen receptors of MCF-7 cells and potentiation of antiproliferative effects of tamoxifen in combination with OK-432. Oncology 54(5):414–423. https://doi.org/10.1159/000227728
Arnedos M, Vicier C, Loi S, Lefebvre C, Michiels S, Bonnefoi H, Andre F (2015) Precision medicine for metastatic breast cancer—limitations and solutions. Nat Rev Clin Oncol 12(12):693–704. https://doi.org/10.1038/nrclinonc.2015.123
Arora R, Yates C, Gary BD, McClellan S, Tan M, Xi Y, Reed E, Piazza GA, Owen LB, Dean-Colomb W (2014) Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. PLoS One 9(6):e98370. https://doi.org/10.1371/journal.pone.0098370
Arora D, Kumar A, Gupta P, Chashoo G, Jaglan S (2017) Preparation, characterization and cytotoxic evaluation of bovine serum albumin nanoparticles encapsulating 5-methylmellein: a secondary metabolite isolated from Xylaria psidii. Bioorg Med Chem Lett 27(23):5126–5130. https://doi.org/10.1016/j.bmcl.2017.10.064
Asaishi K, Okazaki M, Hayasaka H (1988) Local treatment of locally recurrent breast cancers. Gan To Kagaku Ryoho 15(4 Pt 2-2):1325–1330
Asatiani MD, Wasser SP, Nevo E, Ruimi N, Mahajna J, Reznick AZ (2011) The Shaggy Inc Cap medicinal mushroom, Coprinus comatus (O.F.Mull. Fr.) Pers. (Agaricomycetideae) substances interfere with H2O2 induction of the NF-kappaB pathway through inhibition of Ikappaalpha phosphorylation in MCF7 breast cancer cells. Int J Med Mushrooms 13(1):19–25. https://doi.org/10.1615/intjmedmushr.v13.i1.30
Barbieri A, Quagliariello V, Del Vecchio V, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C (2017) Anticancer and anti-Inflammatory properties of Ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients 9(3):E210. https://doi.org/10.3390/nu9030210
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424
Cai H, Li J, Gu B, Xiao Y, Chen R, Liu X, Xie X, Cao L (2018) Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J Ethnopharmacol 214:106–112. https://doi.org/10.1016/j.jep.2017.12.012
Cardoso F, Harbeck N, Barrios C, Bergh J, Cortés J, El Saghir N, Francis PA, Hudis CA, Ohno S, Partridge AH (2017) Research needs in breast cancer. Ann Oncol 28(2):208–217. https://doi.org/10.1093/annonc/mdw571
Chan HHL (2009) Formulation and use of ergosta-7, 22-dien-3beta-ol. Patent US2009247497 A1.
Chan JS, Asatiani MD, Sharvit LE, Trabelcy B, Barseghyan GS, Wasser SP (2015) Chemical composition and medicinal value of the new Ganoderma tsugae var. jannieae CBS-120304 medicinal higher basidiomycete mushroom. Int J Med Mushrooms 17(8):735–747. https://doi.org/10.1615/intjmedmushrooms.v17.i8.40
Chang YC, Hsiao YM, Wu MF, Ou CC, Lin YW, Lue KH, Ko JL (2013) Interruption of lung cancer cell migration and proliferation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes. J Agric Food Chem 61(49):12044–12052. https://doi.org/10.1021/jf4030272
Chang CT, Hseu YC, Thiyagarajan V, Huang HC, Hsu LS, Huang PJ, Liu JY, Liao JW, Yang HL (2017a) Antrodia salmonea induces G (2) cell-cycle arrest in human triple-negative breast cancer (MDA-MB-231) cells and suppresses tumor growth in athymic nude mice. J Ethnopharmacol 196:9–19. https://doi.org/10.1016/j.jep.2016.12.018
Chang Y, Zhang M, Jiang Y, Liu Y, Luo H, Hao C, Zeng P, Zhang L (2017b) Preclinical and clinical studies of Coriolus versicolor polysaccharopeptide as an immunotherapeutic in China. Discov Med 23(127):207–219
Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury M, Adams LS, Williams D (2006) Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). Cancer Res 66(24):12026–12034. https://doi.org/10.1158/0008-5472.CAN-06-2206
Chen GT, Fu YX, Yang WJ, Hu QH, Zhao LY (2018) Effects of polysaccharides from the base of Flammulina velutipes stipe on growth of murine RAW264.7, B16F10 and L929 cells. Int J Biol Macromol 107(Pt B):2150–2156
Chen JH, Wu THA, Tzeng DTW, Huang CC, Tzeng YM, Chao TY (2019a) Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling. Phytomedicine. 52:70–78. https://doi.org/10.1016/j.phymed.2018.09.213
Chen YC, Liu YC, El-Shazly M, Wu TY, Chang JG, Wu YC (2019b) Antrodia cinnamomea, a treasured medicinal mushroom, induces growth arrest in breast cancer cells, T47D cells: new mechanisms emerge. Int J Mol Sci 20(4):E833. https://doi.org/10.3390/ijms20040833
Cheong PCH, Yong YS, Fatima A, Ng ST, Tan CS, Kong BH, Tan NH, Rajarajeswaran J, Fung SY (2019) Cloning, overexpression, purification, and modeling of a lectin (Rhinocelectin) with antiproliferative activity from tiger milk mushroom, Lignosus rhinocerus. IUBMB Life 71(10):1579–1594. https://doi.org/10.1002/iub.2101
Choi S, Lim MH, Kim KM, Jeon BH, Song WO, Kim TW (2011) Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor. Toxicol A ppl Pharmacol 257(2):165–173. https://doi.org/10.1016/j.taap.2011.08.030
Chu CL, Chen DC, Lin CC (2011) A novel adjuvant Ling Zhi-8 for cancer DNA vaccines. Hum Vaccin 7(11):1161–1164. https://doi.org/10.4161/hv.7.11.17753
Chung MJ, Chung CK, Jeong Y, Ham SS (2010) Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in BALBC/c mice bearing sarcoma-180 cells. Nutr Res Pract 4(3):177–182. https://doi.org/10.4162/nrp.2010.4.3.177
Clement F, Venkatesh YP (2010) Dietary garlic (Allium sativum) lectins, ASA I and ASA II, are highly stable and immunogenic. Int Immunopharmacol 10(10):1161–1169
Cutress RI, McIntosh SA, Potter S, Goyal A, Kirwan CC, Harvey J, Francis A, Carmichael AR, Vidya R, Vaidya JS, Fairbrother P, Benson JR, Reed MWR (2018) Opportunities and priorities for breast surgical research. Lancet Oncol 19(10):e521–e533. https://doi.org/10.1016/S1470-2045(18)30511-4
Deng G, Lin H, Seidman A, Fornier M, D’Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B (2009) A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol 135(9):1215–1221. https://doi.org/10.1007/s00432-009-0562-z
Deveci E, Tel-Çayan G, Duru ME, Öztürk M (2019) Isolation, characterization, and bioactivities of compounds from Fuscoporia torulosa mushroom. J Food Biochem 43(12):e13074. https://doi.org/10.1111/jfbc.13074
Dong S, Furutani Y, Kimura S, Zhu Y, Kawabata K, Furutani M, Nishikawa T, Tanaka T, Masaki T, Matsuoka R, Kiyama R (2013) Brefeldin A is an estrogenic, Erk1/2-activating component in the extract of Agaricus blazei mycelia. J Agric Food Chem 61(1):128–136. https://doi.org/10.1021/jf304546a
Dubey SK, Chaturvedi VK, Mishra D, Bajpeyee A, Tiwari A, Singh MP (2019) Role of edible mushroom as a potent therapeutics for the diabetes and obesity. 3 Biotech 9(12):450. https://doi.org/10.1007/s13205-019-1982-3
Dunneram Y, Greenwood DC, Cade JE (2019) Diet and risk of breast, endometrial and ovarian cancer: UK Women’s Cohort Study. Br J Nutr 122(5):564–574
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F (2013) Critical research gaps and translational prioritiesfor the successful prevention and treatment ofbreast cancer. Breast Cancer Res 15:R92. https://doi.org/10.1186/bcr3493
El-Deeb NM, El-Adawi HI, El-Wahab AEA, Haddad AM, El Enshasy HA, He YW, Davis KR (2019) Modulation of NKG2D, KIR2DL and cytokine production by Pleurotus ostreatus glucan enhances natural killer cell cytotoxicity toward cancer cells. Front Cell Dev Biol 7:165. https://doi.org/10.3389/fcell.2019.00165
Eliza WL, Fai CK, Chung LP (2012) Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Patents Inflamm Allergy Drug Discov 6(1):78–87. https://doi.org/10.2174/187221312798889310
Eng C (2010) Are herbal medicines ripe for the cancer clinic? Sci Transl Med 2:1–5
Engel CL, Rasanayagam MS, Gray JM, Rizzo J (2018) Work and breast cancer: recommendations to address research needs. New Solut 28(1):79–95. https://doi.org/10.1177/1048291118758713
Erkel G, Anke T, Sterner O (1996) Inhibition of NF -kappa B kappa B kappa B kappa B activation activation by panepoxydone. Biochem Biophys Res Commun 226(1):214-21.21. https://doi.org/10.1006/bbrc.1996.1335
Esquivel-Velázquez M, Ostoa-Saloma P, Palacios-Arreola MI, Nava-Castro E, Castro JI, Morales-Montor J (2015) The role of cytokines in breast cancer development and pogression. J Interf Cytokine Res 35(1):1–16
Fan QY, Yin X, Li ZH, Li Y, Liu JK, Feng T, Zhao BH (2014) Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureus. Chin J Nat Med 12(9):685–688. https://doi.org/10.1016/S1875-5364(14)60104-7
Fang N, Li Q, Yu S, Zhang J, He L, Ronis MJ, Badger TM (2006) Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms. J Altern Complement Med 12(2):125–132. https://doi.org/10.1089/acm.2006.12.125
Fang X, Jiang Y, Ji H, Zhao L, Xiao W, Wang Z, Ding G (2015) The synergistic beneficial effects of Ginkgo flavonoid and Coriolus versicolor polysaccharide for memory improvements in a mouse model of dementia. Evid Based Complement Alternat Med 2015:128394. https://doi.org/10.1155/2015/128394
Fangkrathok N, Sripanidkulchai B, Umehara K, Noguchi H (2013) Bioactive ergostanoids and a new polyhydroxyoctane from Lentinus polychrous mycelia and their inhibitory effects on E2-enhanced cell proliferation of T47D cells. Nat Prod Res 27(18):1611–1619. https://doi.org/10.1080/14786419.2012.742079
Feng W, Yang J, Xu X, Liu Q (2010) Quantitative determination of lanostane triterpenes in Fomes officinalis and their fragmentation study by HPLC-ESI. Phytochem Anal 21(6):531–538. https://doi.org/10.1002/pca.1228
Ferrigni E, Bergom C, Yin Z, Szabo A, Kong AL (2019) Breast cancer in women aged 80 years or older: an analysis of treatment patterns and disease outcomes. Clin Breast Cancer 19(3):157–164
Frenkel M, Abrams DI, Ladas EJ, Deng G, Hardy M, Capodice JL, Winegardner MF, Gubili JK, Yeung KS, Kussmann H, Block KI (2013) Integrating dietary supplements into cancer care. Integr Cancer Ther 12(5):369–384. https://doi.org/10.1177/1534735412473642
Fujii T, Saito K, Oguchi Y, Matsunaga K, Kobayashi Y, Yoshikumi C, Taguchi T (1988) Effects of the protein-bound polysaccharide preparation, PSK on spontaneous breast cancer in mice. J Int Med Res 16(4):286–293. https://doi.org/10.1177/030006058801600406
Fung SY, Tan NH, Kong BH, Lee SS, Tan YS, Sabaratnam V (2017) Acute toxicity study and the in vitro cytotoxicity of a black Lingzhi medicinal mushroom, Amauroderma rugosum (Agaricomycetes), from Malaysia. Int J Med Mushrooms 19(12):1093–1099. https://doi.org/10.1615/IntJMedMushrooms.2017024550
Gabor F, Wirth M, Jurkovich B, Haberl I, Theyer G, Walcher G, Hamilton G (1997) Lectin-mediated bioadhesion: proteolytic stability and binding-characteristics of wheat germ agglutinin and Solanum tuberosum lectin on Caco-2, HT-29 and human colonocytes. J Control Release 49(1):27–37
Ghasemi F, Sarabi PZ, Athari SS, Esmaeilzadeh A (2019) Therapeutics strategies against cancer stem cell in breast cancer. Int J Biochem Cell Biol 109:76–81. https://doi.org/10.1016/j.biocel.2019.01.015
Gong S, Zhang HQ, Yin WP, Yin QZ, Zhang Y, Gu ZL, Qian ZM, Tang PL (1998) Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides. Zhongguo Yao Li Xue Bao 19(1):67–70
Gonul O, Aydin HH, Kalmis E, Kayalar H, Ozkaya AB, Atay S, Ak H (2015) Effects of Ganoderma lucidum (higher Basidiomycetes) extracts on the miRNA profile and telomerase activity of the MCF-7 breast cancer cell line. Int J Med Mushrooms 17(3):231–239. https://doi.org/10.1615/intjmedmushrooms.v17.i3.30
Gu YH, Leonard J (2006) In vitro effects on proliferation, apoptosis and colony inhibition in ER-dependent and ER-independent human breast cancer cells by selected mushroom species. Oncol Rep 15(2):417–423. https://doi.org/10.1615/intjmedmushrooms.v17.i3.30
Hao J, Zhang X, Yu W, Wang R, Xue Z, Kou X (2017) Identification and evaluation of bioactivity of compounds from the mushroom Pleurotus nebrodensis (Agaricomycetes) against breast cancer. Int J Med Mushrooms 19(9):839–848. https://doi.org/10.1615/IntJMedMushrooms.2017024372
Haque MA, Islam MAU (2019) Pleurotus highking mushroom induces apoptosis by altering the balance of proapoptotic and antiapoptotic genes in breast cancer cells and inhibits tumor sphere formation. Medicina (Kaunas) 55(11):E716. https://doi.org/10.3390/medicina55110716
He JB, Tao J, Miao XS, Bu W, Zhang S, Dong ZJ, Li ZH, Feng T, Liu JK (2015) Seven new drimane-type sesquiterpenoids from cultures of fungus Laetiporus sulphureus. Fitoterapia. 102:1–6. https://doi.org/10.1016/j.fitote.2015.01.022
Ho CY, Lau CB, Kim CF, Leung KN, Fung KP, Tse TF, Chan HH, Chow MS (2004a) Differential effect of Coriolus versicolor (Yunzhi) extract on cytokine production by murine lymphocytes in vitro. Int Immunopharmacol 4(12):1549–1557. https://doi.org/10.1016/j.intimp.2004.07.021
Ho JC, Konerding MA, Gaumann A, Groth M, Liu WK (2004b) Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice. Life Sci 75(11):1343–1356. https://doi.org/10.1016/j.lfs.2004.02.021
Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB (2005) Differential anti-tumor activity of Coriolus versicolor (Yunzhi) extract through p53- and/or Bcl-2-dependent apoptotic pathway in human breast cancer cells. Cancer Biol Ther 4(6):638–644. https://doi.org/10.4161/cbt.4.6.1721
Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB (2006) Coriolus versicolor (Yunzhi) extract attenuates growth of human leukemia xenografts and induces apoptosis through the mitochondrial pathway. Oncol Rep 16(3):609–616
Hong SA, Kim K, Nam SJ, Kong G, Kim MK (2008) A case-control study on the dietary intake of mushrooms and breast cancer risk among Korean women. Int J Cancer 122(4):919–923
Houghton LC, Howland RE, McDonald JA (2019) Mobilizing breast cancer prevention research through smartphone apps: a systematic review of the literature. Front Public Health 7:298. https://doi.org/10.3389/fpubh.2019.00298
Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WT, Yang HL (2019a) Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers. J Cell Physiol 234(4):4125–4139. https://doi.org/10.1002/jcp.27222
Hseu YC, Lin YC, Rajendran P, Thigarajan V, Mathew DC, Lin KY, Way TD, Liao JW, Yang HL (2019b) Antrodia salmonea suppresses invasion and metastasis in triple negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway. Food Chem Toxicol 124:219–230. https://doi.org/10.1016/j.fct.2018.12.009
Hsu KD, Cheng KC (2018) From nutraceutical to clinical trial: frontiers in Ganoderma development. Appl Microbiol Biotechnol 102(21):9037–9051. https://doi.org/10.1007/s00253-018-9326-5
Hu H, Ahn NS, Yang X, Lee YS, Kang KS (2002) Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer 102(3):250–253. https://doi.org/10.1002/ijc.10707
Hu Y, Zhu M, Tian G, Zhao L, Wang H, Ng TB (2017) Isolation of a protease-resistant and pH-stable α-galactosidase displaying hydrolytic efficacy toward raffinose family oligosaccharides from the button mushroom Agaricus bisporus. Int J Biol Macromol 104:576–583
Hu B, Yan W, Wang M, Cui X, Hu Y, Chen Q, Zhang Y, Qi X, Jiang J (2019) Huaier polysaccharide inhibits the stem-like characteristics of ERα-36(high) triple negative breast cancer cells via inactivation of the ERα-36 signaling pathway. Int J Biol Sci 15(7):1358–1367. https://doi.org/10.7150/ijbs.27360
Huang WT, Tai R, Hseu RS, Huang CT (2011) Overexpression and characterization of a thermostable, pH-stable and organic solvent-tolerant Ganoderma fornicatum laccase in Pichia pastoris. Process Biochem 46:1469–1474
Iino Y, Yokoe T, Maemura M, Horiguchi J, Takei H, Ohwada S, Morishita Y (1995) Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer. Anticancer Res 15(6B):2907–2911
Israilides C, Kletsas D, Arapoglou D, Philippoussis A, Pratsinis H, Ebringerová A, Hríbalová V, Harding SE (2008) In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes. Phytomedicine. 15(6-7):512–519. https://doi.org/10.1016/j.phymed.2007.11.029
Jang EH, Jang SY, Cho IH, Hong D, Jung B, Park MJ, Kim JH (2015) Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha. Biochem Biophys Res Commun 463(4):917–922. https://doi.org/10.1016/j.bbrc.2015.06.035
Jedinak A, Sliva D (2008) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. Int J Oncol 33(6):1307–1313
Jeong MH, Lee CM, Lee SW, Seo SY, Seo MJ, Kang BW, Jeong YK, Choi YJ, Yang KM, Jo WS (2013) Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growth delay in mouse-derived breast cancer. Oncol Rep 30(4):1996–2002. https://doi.org/10.3892/or.2013.2660
Jia W, Feng J, Zhang JS, Lin CC, Wang WH, Chen HG (2017) Structural characteristics of the novel polysaccharide FVPA1 from winter culinary-medicinal mushroom, Flammulina velutipes (Agaricomycetes), capable of enhancing natural killer cell activity against K562 tumor cells. Int J Med Mushrooms 19(6):535–546. https://doi.org/10.1615/IntJMedMushrooms.v19.i6.50
Jiang J, Sliva D (2010) Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells. Int J Oncol 37(6):1529–1536. https://doi.org/10.3892/ijo_00000806
Jiang J, Slivova V, Sliva D (2006) Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling. Int J Oncol 29(3):695–703
Jiang J, Jedinak A, Sliva D (2011) Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. Biochem Biophys Res Commun 415(2):325–329. https://doi.org/10.1016/j.bbrc.2011.10.055
Jiang J, Thyagarajan-Sahu A, Loganathan J, Eliaz I, Terry C, Sandusky GE, Sliva D (2012) BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer. Oncol Rep 28(4):1139–1145. https://doi.org/10.3892/or.2012.1936
Jiao C, Xie YZ, Yang X, Li H, Li XM, Pan HH, Cai MH, Zhong HM, Yang BB (2013) Anticancer activity of Amauroderma rude. PLoS One 8(6):e66504. https://doi.org/10.1371/journal.pone.0066504
Jiao C, Chen W, Tan X, Liang H, Li J, Yun H, He C, Chen J, Ma X, Xie Y, Yang BB (2020) Ganoderma lucidum spore oil induces apoptosis of breast cancer cells in vitro and in vivo by activating caspase-3 and caspase-9. J Ethnopharmacol 247:112256. https://doi.org/10.1016/j.jep.2019.112256
Jiménez-Medina E, Berruguilla E, Romero I, Algarra I, Collado A, Garrido F, Garcia-Lora A (2008) The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis. BMC Cancer 8:78. https://doi.org/10.1186/1471-2407-8-78
Jin CY, Kim GY, Choi YH (2008) Induction of apoptosis by aqueous extract of Cordyceps militaris through activation of caspases and inactivation of Akt inhuman breast cancer MDA-MB-231 Cells. J Microbiol Biotechnol 18(12):1997–2003
Jin Y, Meng X, Qiu Z, Su Y, Yu P, Qu P (2018) Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris. Saudi J Biol Sci 25(5):991–995. https://doi.org/10.1016/j.sjbs.2018.05.016
Jordan JL, Nowak A, Lee TD (2010) Activation of innate immunity to reduce lung metastases in breast cancer. Cancer Immunol Immunother 59(5):789–797. https://doi.org/10.1007/s00262-009-0800-x
Jung JW, Moon SM, Park BR, Kim SG, Kim JS, Kim CS (2014) Anti-cancer activity of the protein extract from Lyophyllum shimeji in KB human oral squamous cell carcinoma. Oral Biol Res 38(2):99–105
Khan MA, Tania M (2018) Cordycepin in anticancer research: molecular mechanism of therapeutic effects. Curr Med Chem. https://doi.org/10.2174/0929867325666181001105749
Kidd PM (2000) The use of mushroom glucans and proteoglycans in cancer treatment. Altern Med Rev 5(1):4–27
Kim TH, Kim JS, Kim ZH, Huang RB, Chae YL, Wang RS (2016) Induction of apoptosis in MCF-7 human breast cancer cells by Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelium). Mol Med Rep 13(2):1243–1249. https://doi.org/10.3892/mmr.2015.4655
Ko CH, Yue GG, Gao S, Luo KW, Siu WS, Shum WT, Shiu HT, Lee JK, Li G, Leung PC, Evdokiou A, Lau CB (2017) Evaluation of the combined use of metronomic zoledronic acid and Coriolus versicolor in intratibial breast cancer mouse model. J Ethnopharmacol 204:77–85. https://doi.org/10.1016/j.jep.2017.04.007
Kodama N, Komuta K, Nanba H (2003) Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. J Med Food 6(4):371–377. https://doi.org/10.1089/109662003772519949
Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Ichida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, Nagano H (2017) Correlation between NKG2DL expression and antitumor effect of protein-bound polysaccharide-K in tumor-bearing mouse models. Anticancer Res 37(8):4093–4101. https://doi.org/10.21873/anticanres.11796
Konno S, Chu K, Feuer N, Phillips J, Choudhury M (2015) Potent anticancer effects of bioactive mushroom extracts (Phellinus linteus) on a variety of human cancer cells. J Clin Med Res 7(2):76–82. https://doi.org/10.14740/jocmr1996w
Kosaka A, Wani T, Hattori Y, Yamashita A (1982) Effect of lentinan administration of adrenalectomized rats and patients with breast cancer. Gan To Kagaku Ryoho 9(8):1474–1481
Kowalczewska M, Piotrowski J, Jędrzejewski T, Kozak W (2016) Polysaccharide peptides from Coriolus versicolor exert differential immunomodulatory effects on blood lymphocytes and breast cancer cell line MCF-7 in vitro. Immunol Lett 174:37–44. https://doi.org/10.1016/j.imlet.2016.04.010
Krasnopolskaya LM, Shuktueva MI, Avtonomova AV, Yarina MS, Dzhavakhyan BR, Isakova EB, Bukhman VM (2016) Antitumor and antioxidant properties of water-soluble polysaccharides from submerged mycelium of Flammulina velutipes. Antibiot Khimioter 61(11-12):16–20
Krishnamoorthy D, Sankaran M (2016) Modulatory effect of Pleurotus ostreatus on oxidant/antioxidant status in 7, 12-dimethylbenz (a) anthracene induced mammary carcinoma in experimental rats—a dose-response study. J Cancer Res Ther 12(1):386–394. https://doi.org/10.4103/0973-1482.148691
Kumar KJS, Vani MG, Hsieh HW, Lin CC, Wang SY (2019) Antcin-A modulates epithelial-to-mesenchymal transition and inhibits migratory and invasive potentials of human breast cancer cells via p53-mediated miR-200c activation. Planta Med 85(9-10):755–765. https://doi.org/10.1055/a-0942-2087
Lau CB, Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan HH, Chow MS (2004) Cytotoxic activities of Coriolus versicolor (Yunzhi) extract on human leukemia and lymphoma cells by induction of apoptosis. Life Sci 75(7):797–808
Lavi I, Friesem D, Geresh S, Hadar Y, Schwartz B (2006) An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells. Cancer Lett 244(1):61–70
Lavi I, Levinson D, Peri I, Tekoah Y, Hadar Y, Schwartz B (2010) Chemical characterization, antiproliferative and antiadhesive properties of polysaccharides extracted from Pleurotus pulmonarius mycelium and fruiting bodies. Appl Microbiol Biotechnol 85(6):1977–1990. https://doi.org/10.1007/s00253-009-2296-x
Lavi I, Nimri L, Levinson D, Peri I, Hadar Y, Schwartz B (2012) Glucans from the edible mushroom Pleurotus pulmonarius inhibit colitis-associated colon carcinogenesis in mice. J Gastroenterol 47(5):504–518. https://doi.org/10.1007/s00535-011-0514-7
Lee CC, Yang HL,Way TD, Kumar KJ, Juan YC, Cho HJ, Lin KY, Hsu LS, Chen SC, Hseu YC (2012) Inhibition of cell growth and induction of apoptosis by Antrodia camphorata in HER-2/neu-overexpressing breast cancer cells through the induction of ROS, depletion of HER-2/neu, and disruption of the PI3K/Akt signaling pathway. Evid Based Complement Alternat Med 2012:702857. https://doi.org/10.1155/2012/702857
Lee D, Lee WY, Jung K, Kwon YS, Kim D, Hwang GS, Kim CE, Lee S, Kang KS (2019a) The inhibitory effect of cordycepin on the proliferation of MCF-7 breast cancer cells, and its mechanism: an investigation using network pharmacology-based analysis. Biomolecules 9(9):E407. https://doi.org/10.3390/biom9090407
Lee SO, Lee MH, Lee KR, Lee EO, Lee HJ (2019b) Fomes fomentarius ethanol extract exerts inhibition of cell growth and motility induction of apoptosis via targeting AKT in human breast cancer MDA-MB-231 cells. Int J Mol Sci 20(5):E1147. https://doi.org/10.3390/ijms20051147
Lee SR, Seok S, Ryoo R, Choi SU, Kim KH (2019c) Macrocyclic trichothecene mycotoxins from a deadly poisonous mushroom, Podostroma cornu-damae. J Nat Prod 82(1):122–128. https://doi.org/10.1021/acs.jnatprod.8b00823
Li M, Zhang G, Wang H, Ng T (2010a) Purification and characterization of a laccase from the edible wild mushroom Tricholoma mongolicum. J Microbiol Biotechnol 20(7):1069–1076. https://doi.org/10.4014/jmb.0912.12033
Li Y, Zhang G, Ng TB, Wang H (2010b) A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. J Biomed Biotechnol 2010:716515. https://doi.org/10.1155/2010/716515
Li F, Wang Y, Wang X, Li J, Cui H, Niu M (2012) Ganoderic acids suppress growth and angiogenesis by modulating the NF-κB signaling pathway in breast cancer cells. Int J Clin Pharmacol Ther 50(10):712–721. https://doi.org/10.5414/CP201663
Li M, Wang H, Ng TB (2013) Isolation of a phytase with distinctive characteristics from an edible mushroom, Pleurotus eryngii. Protein Pept Lett 20(4):459–466
Li X, Wu Q, Xie Y, Ding Y, Du WW, Sdiri M, Yang BB (2015) Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors. Oncotarget 6(19):17832–17846. https://doi.org/10.18632/oncotarget.4026
Li X, He Y, Zeng P, Liu Y, Zhang M, Hao C, Wang H, Lv Z, Zhang L (2019) Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China. J Cell Mol Med 23(1):4–20. https://doi.org/10.1111/jcmm.13564
Lin YS, Lin YY, Yang YH, Lin CL, Kuan FC, Lu CN, Chang GH, Tsai MS, Hsu CM, Yeh RA, Yang PR, Lee IY, Shu LH, Cheng YC, Liu HT, Lee KD, Chang DC, Wu CY (2018) Antrodia cinnamomea extract inhibits the proliferation of tamoxifen-resistant breast cancer cells through apoptosis and skp2/microRNAs pathway. BMC Complement Altern Med 18(1):152. https://doi.org/10.1186/s12906-018-2204-y
Linh DT, Hien BT, do Que D, Lam DM, Arnold N, Schmidt J, Porzel A, Quang DN (2014) Cytotoxic constituents from the Vietnamese fungus Xylaria schweinitzii. Nat Prod Commun 9(5):659–660
Liu WK, Ng TB, Sze SF, Tsui KW (1993) Activation of peritoneal macrophages by polysaccharopeptide from the mushroom. Coriolus Versicolor Immunopharmacol 26(2):139–146. https://doi.org/10.1016/0162-3109(93)90006-c
Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP (2009) Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines. J Agric Food Chem 57(8):3087–3093. https://doi.org/10.1021/jf900011f
Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H, Sliva D (2014) The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes. Int J Oncol 44(6):2009–2015. https://doi.org/10.3892/ijo.2014.2375
Lu H, Yang Y, Gad E, Inatsuka C, Wenner CA, Disis ML, Standish LJ (2011) TLR2 agonist PSK activates human NK cells and enhances the antitumor effect of HER2-targeted monoclonal antibody therapy. Clin Cancer Res 17(21):6742–6753. https://doi.org/10.1158/1078-0432.CCR-11-1142
Luo KW, Yue GG, Ko CH, Lee JK, Gao S, Li LF, Li G, Fung KP, Leung PC, Lau CB (2014) In vivo and in vitro anti-tumor and anti-metastasis effects of Coriolus versicolor aqueous extract on mouse mammary 4T1 carcinoma. Phytomedicine. 21(8-9):1078–1087. https://doi.org/10.1016/j.phymed.2014.04.020
Ma L, Chen H, Dong P, Lu X (2013 Aug 15) Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus. Food Chem 139(1-4):503–508. https://doi.org/10.1016/j.foodchem.2013.01.030
Mansour A, Daba A, Baddour N, El-Saadani M, Aleem E (2012) Schizophyllan inhibits the development of mammary and hepatic carcinomas induced by 7,12 dimethylbenz(α)anthracene and decreases cell proliferation: comparison with tamoxifen. J Cancer Res Clin Oncol 138(9):1579–1596. https://doi.org/10.1007/s00432-012-1224-0
Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F (2019) Identification of biologically active Ganoderma lucidum compounds and synthesis of improved derivatives that confer anti-cancer activities in vitro. Front Pharmacol 10:15. https://doi.org/10.3389/fphar.2019.00115
Mizerska-Dudka M, Jaszek M, Błachowicz A, Rejczak TP, Matuszewska A, Osińska-Jaroszuk M, Stefaniuk D, Janusz G, Sulej J, Kandefer-Szerszeń M (2015) Fungus Cerrena unicolor as an effective source of new antiviral, immunomodulatory, and anticancer compounds. Int J Biol Macromol 79:459–468. https://doi.org/10.1016/j.ijbiomac.2015.05.015
Monro JA (2003) Treatment of cancer with mushroom products. Arch Environ Health 58(8):533–537. https://doi.org/10.3200/AEOH.58.8.533-537
Morino M, Tsuzuki T, Ishikawa Y, Shirakami T, Yoshimura M, Kiyosuke Y, Matsunaga K, Yoshikumi C, Saijo N (1997) Specific regulation of HSPs in human tumor cell lines by PSK. In Vivo 11(3):261–264
Nagajyothi PC, Sreekanth TV, Lee JI, Lee KD (2014) Mycosynthesis: antibacterial, antioxidant and antiproliferative activities of silver nanoparticles synthesized from Inonotus obliquus (Chaga mushroom) extract. J Photochem Photobiol B 130:299–304. https://doi.org/10.1016/j.jphotobiol.2013.11.022
Nagashima Y, Sanpei N, Yamamoto S, Yoshino S, Tangoku A, Oka M (2005) Evaluation of host immunity and side effects in breast cancer patients treated with adjuvant chemotherapy (FEC therapy). Gan To Kagaku Ryoho 32(11):1550–1552
Nakamura K, Shinozuka K, Yoshikawa N (2015) Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. J Pharmacol Sci 127(1):53–56. https://doi.org/10.1016/j.jphs.2014.09.001
Ng TB (1998) A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol 30(1):1–4. https://doi.org/10.1016/s0306-3623(97)00076-1
Ng TB, Chan WY (1997) Polysaccharopeptide from the mushroom Coriolus versicolor possesses analgesic activity but does not produce adverse effects on female reproductive or embryonic development in mice. Gen Pharmacol 29(2):269–273. https://doi.org/10.1016/s0306-3623(96)00412-0
Nimri L, Spivak O, Tal D, Schälling D, Peri I, Graeve L, Salame TM, Yarden O, Hadar Y, Schwartz B et al (2017) Oncotarget 8(17):28854–28864. https://doi.org/10.18632/oncotarget.15859
Novaković A, Karaman M, Kaišarević, S, Novi S, Radusin, T, (2019) Auricularia auricula–judae (Bull.: fr.) Wettst. 1885 cytotoxicity on breast cancer cell line (MCF 7), Proceedings of III International Congress Food Technology, Quality and Safety. In AGRIS, 113-116. Publisher Institute of Food Technology, Novi Sad (Serbia). ISBN 978-86-7994-050-6.
Palacios S, Losa F, Dexeus D, Cortés J (2017) Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women. BMC Womens Health 17(1):21. https://doi.org/10.1186/s12905-017-0374-2
Pan WL, Wong JH, Fang EF, Chan YS, Ye XJ, Ng TB (2013) Differential inhibitory potencies and mechanisms of the type I ribosome inactivating protein marmorin on estrogen receptor (ER)-positive and ER-negative breast cancer cells. Biochim Biophys Acta 1833(5):987–996. https://doi.org/10.1016/j.bbamcr.2012.12.013
Park JH, Ryu CS, Kim HN, Na YJ, Park HJ, Kim H (2004) A sialic acid-specific lectin from the mushroom Paecilomyces japonica that exhibits hemagglutination activity and cytotoxicity. Protein Pept Lett 11(6):563–569. https://doi.org/10.2174/0929866043406445
Partridge AH, Carey LA (2017) Unmet needs in clinical research in breast cancer: where do we need to go? Clin Cancer Res 23(11):2611–2616. https://doi.org/10.1158/1078-0432.CCR-16-2633
Patel S, Goyal A (2012) Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech 2(1):1–15
Pawlikowska M, Jędrzejewski T, Piotrowski J, Kozak W (2016) Fever-range hyperthermia inhibits cells immune response to protein-bound polysaccharides derived from Coriolus versicolor extract. Mol Immunol 80:50–57. https://doi.org/10.1016/j.molimm.2016.10.013
Petrova RD, Mahajna J, Wasser SP, Ruimi N, Denchev CM, Sussan S, Nevo E, Reznick AZ (2009) Marasmius oreades substances block NF-kappaB activity through interference with IKK activation pathway. Mol Biol Rep 36(4):737–744. https://doi.org/10.1007/s11033-008-9237-0
Qi ZH, Meng J, Wang ZL, Sun HZ, Gong Y (2016) Antitumor effect of Ganoderma lipsiense extract on triple-negative breast cancer model mice and mechanism study. Zhongguo Zhong Xi Yi Jie He Za Zhi 36(3):366–369
Qian L, Zhang Y, Liu F (2016) Purification and characterization of a ∼43 kDa antioxidant protein with antitumor activity from Pholiota nameko. J Sci Food Agric 96(3):1044–1052. https://doi.org/10.1002/jsfa.7194
Qin P, Li X, Yang H, Wang ZY, Lu D (2019) Therapeutic potential and biological applications of cordycepin and metabolic mechanisms in cordycepin-producing fungi. Molecules 24(12):E2231. https://doi.org/10.3390/molecules24122231
Qiu J, Zhang H, Wang Z (2018a) Auricularia auriculajudae polysaccharide-cisplatin complexes conjugated with folic acid as new tumor targeting agents. Int J Biol Macromol 120(Pt A):966–974. https://doi.org/10.1016/j.ijbiomac.2018.05.051
Qiu J, Zhang H, Wang Z, Liu D, Liu S, Han W, Regenstein JM, Geng L (2018b) The antitumor effect of folic acid conjugated-Auricularia auricular polysaccharide-cisplatin complex on cervical carcinoma cells in nude mice. Int J Biol Macromol 107(Pt B):2180–2189. https://doi.org/10.1016/j.ijbiomac.2017.10.087
Rachmawati H, Sundari S, Nabila N, Tandrasasmita OM, Amalia R, Siahaan TJ, Tjandrawinata RR, Ismaya WT (2019) Orf239342 from the mushroom Agaricus bisporus is a mannose binding protein. Biochem Biophys Res Commun 515(1):99–103. https://doi.org/10.1016/j.bbrc.2019.05.107
Ramesh V, Santosh K, Anand TD, Shanmugaiah V, Kotamraju S, Karunakaran C, Rajendran A (2015) Novel bioactive wild medicinal mushroom—Xylaria sp. R006 (Ascomycetes) against multidrug resistant human bacterial pathogens and human cancer cell lines. Int J Med Mushrooms 17(10):1005–1017. https://doi.org/10.1615/intjmedmushrooms.v17.i10.100
Rao YK, Wu AT, Geethangili M, Huang MT, Chao WJ, Wu CH, Deng WP, Yeh CT, Tzeng YM (2011) Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells. Chem Res Toxicol 24(2):238–245. https://doi.org/10.1021/tx100318m
Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM (2018) Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway. Oncotarget 9(89):35907–35921. https://doi.org/10.18632/oncotarget.26294
Rodríguez-Valentín M, López S, Rivera M, Ríos-Olivares E, Cubano L, Boukli NM (2018) Naturally derived anti-HIV polysaccharide peptide (PSP) triggers a Toll-like receptor 4-dependent antiviral immune response. J Immunol Res 2018:8741698. https://doi.org/10.1155/2018/87416989
Roldan-Deamicis A, Alonso E, Brie B, Braico DA, Balogh GA (2016) Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice. Cancer Med 5(9):2427–2441. https://doi.org/10.1002/cam4.744
Rossiana N, Madihah, Nur AA, Mayawatie B, Andayaningsih P (2018) Cytotoxicity assay of ethyl acetate extract shimeji (Lyophyllum shimeji (Kawam.) Hongo) and white oyster mushroom (Pleurotus ostreatus Jacq.) against HCT-116 cell line. IOP Conf Ser: Earth and Environmental Science 197:012007. https://doi.org/10.1088/1755-1315/197/1/012007
Saleh MH, Rashedi I, Keating A (2017) Immunomodulatory properties of Coriolus versicolor: the role of polysaccharopeptide. Front Immunol 8:1087. https://doi.org/10.3389/fimmu.2017.01087
Santibanez JF, Terzic M, Vesovic D, Bugarski D (2013) GE132+Natural: novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. J BUON 18(2):504–510
Scarpari M, Parroni A, Zaccaria M, Fattorini L, Bello C, Fabbri AA, Bianchi G, Scala SV, Zjalic S, Fanelli C (2016) Trametes versicolor bioactive compounds stimulate Aspergillus flavus antioxidant system and inhibit aflatoxin synthesis. Plant Biosyst 150:653–659
Schwartz B, Hadar Y (2014) Possible mechanisms of action of mushroom-derived glucans on inflammatory bowel disease and associated cancer. Ann Transl Med 2(2):19. https://doi.org/10.3978/j.issn.2305-5839.2014.01.03
Sedky NK, El Gammal ZH, Wahba AE, Mosad E, Waly ZY, El-Fallal AA, Arafa RK, El-Badri N (2018) The molecular basis of cytotoxicity of α-spinasterol from Ganoderma resinaceum: Induction of apoptosis and overexpression of p53 in breast and ovarian cancer cell lines. J Cell Biochem 119(5):3892–3902. https://doi.org/10.1002/jcb.26515
Shang D, Zhang J, Wen L, Li Y, Cui Q (2009) Preparation, characterization, and antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from Se-enriched Ganoderma lucidum. J Agric Food Chem 57(17):7737–7742. https://doi.org/10.1021/jf9019344
Shang D, Li Y, Wang C, Wang X, Yu Z, Fu X (2011) A novel polysaccharide from Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells. Oncol Rep 25(1):267–272
Shi X, Zhao Y, Jiao Y, Shi T, Yang X (2013) ROS-dependent mitochondria molecular mechanisms underlying antitumor activity of Pleurotus abalonus acidic polysaccharides in human breast cancer MCF-7 cells. PLoS One 8(5):e64266. https://doi.org/10.1371/journal.pone.0064266
Shin A, Kim J, Lim SY, Kim G, Sung MK, Lee ES, Ro J (2010) Dietary mushroom intake and the risk of breast cancer based on hormone receptor status. Nutr Cancer 62(4):476–483. https://doi.org/10.1080/01635580903441212
Shomali N, Onar O, Karaca B, Demirtas N, Cihan AC, Akata I, Yildirim O (2019) Antioxidant, anticancer, antimicrobial, and antibiofilm properties of the culinary-medicinal fairy ring mushroom, Marasmius oreades (Agaricomycetes). Int J Med Mushrooms 21(6):571–582. https://doi.org/10.1615/IntJMedMushrooms.2019030874
Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd FP Jr, Ho NW (2002) Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem Biophys Res Commun 298(4):603–612. https://doi.org/10.1016/s0006-291x(02)02496-8
Smina TP, Nitha B, Devasagayam TP, Janardhanan KK (2017) Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals. Mutat Res 813:45–51. https://doi.org/10.1016/j.mrgentox.2016.11.010
Soares R, Meireles M, Rocha A, Pirraco A, Obiol D, Alonso E, Joos G, Balogh G (2011) Maitake (D Fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation. J Med Food 14(6):563–572. https://doi.org/10.1089/jmf.2010.0095
Song X, Li Y, Zhang H, Yang Q (2015) The anticancer effect of Huaier (review). Oncol Rep 34(1):12–21. https://doi.org/10.3892/or.2015.3950
Song J, Wang Y, Teng M, Zhang S, Yin M, Lu J, Liu Y, Lee RJ, Wang D, Teng L (2016) Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells. Mol Med Rep 13(6):5132–5140. https://doi.org/10.3892/mmr.2016.5175
Su J, Li D, Chen Q, Li M, Su L, Luo T, Liang D, Lai G, Shuai O, Jiao C, Wu Q, Xie Y, Zhou X (2018) Anti-breast cancer enhancement of a polysaccharide from spore of Ganoderma lucidum with paclitaxel: suppression on tumor metabolism with gut microbiota reshaping. Front Microbiol 9:3099. https://doi.org/10.3389/fmicb.2018.03099
Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM (2016) Ganoderma lucidum combined with the EGFR tyrosine kinase inhibitor, Erlotinib synergize to reduce inflammatory breast cancer progression. J Cancer 7(5):500–511. https://doi.org/10.7150/jca.13599
Sun J, Chen QJ, Cao QQ, Wu YY, Xu LJ, Zhu MJ, Ng TB, Wang HX, Zhang GQ (2012) A laccase with antiproliferative and HIV-I reverse transcriptase inhibitory activities from the mycorrhizal fungus Agaricus placomyces. J Biomed Biotechnol 2012:736472. https://doi.org/10.1155/2012/736472
Sun X, Sun Y, Zhang Q, Zhang H, Yang B, Wang Z, Zhu W, Li B, Wang Q, Kuang H (2014) Screening and comparison of antioxidant activities of polysaccharides from Coriolus versicolor. Int J Biol Macromol 69:12–19. https://doi.org/10.1016/j.ijbiomac.2014.05.027
Sun Y, Hu X, Li W (2017) Antioxidant, antitumor and immunostimulatory activities of the polypeptide from Pleurotus eryngii mycelium. Int J Biol Macromol 97:323–330. https://doi.org/10.1016/j.ijbiomac.2017.01.043
Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R (2014) Clinical characteristics of gynecologic cancer patients who respond to salvage treatment with Lingzhi. Asian Pac J Cancer Prev 15(10):4193–4196
Suzuki N, Takimoto Y, Suzuki R, Arai T, Uebaba K, Nakai M, Strong JM, Tokuda H (2013) Efficacy of oral administration of Lentinula eododes mycelia extract for breast cancer patients undergoing postoperative hormone therapy. Asian Pac J Cancer Prev 14(6):3469–3472. https://doi.org/10.7314/apjcp.2013.14.6.3469
Taguchi T (1983) Effects of lentinan in advanced or recurrent cases of gastric, colorectal, and breast cancer. Gan To Kagaku Ryoho 10(2 Pt 2):387–393
Toi M, Hattori T, Akagi M, Inokuchi K, Orita K, Sugimachi K, Dohi K, Nomura Y, Monden Y, Hamada Y, Morimoto T, Ogawa N (1992) Randomized adjuvant trial to evaluate the addition of tamoxifen and PSK to chemotherapy in patients with primary breast cancer. 5-year results from the Nishi-Nippon Group of the Adjuvant Chemoendocrine Therapy for Breast Cancer Organization. Cancer. 70(10):2475–2483. https://doi.org/10.1002/1097-0142(19921115)70:10<2475::aid-cncr2820701014>3.0.co;2-p
Trovato Salinaro A, Pennisi M, Di Paola R, Scuto M, Crupi R, Cambria MT, Ontario ML, Tomasello M, Uva M, Maiolino L, Calabrese EJ, Cuzzocrea S, Calabrese V (2018) Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms. Immun Ageing 15:8. https://doi.org/10.1186/s12979-017-0108-1
Tsai MY, Hung YC, Chen YH, Chen YH, Huang YC, Kao CW, Su YL, Chiu HH, Rau KM (2016) A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer. BMC Complement Altern Med 16(1):322. https://doi.org/10.1186/s12906-016-1312-9
Tsao SM, Hsu HY (2016) Fucose-containing fraction of Ling-Zhi enhances lipid rafts-dependent ubiquitination of TGFβ receptor degradation and attenuates breast cancer tumorigenesis. Sci Rep 6:36563. https://doi.org/10.1038/srep36563
Valadares F, Garbi Novaes MR, Cañete R (2013) Effect of Agaricus sylvaticus supplementation on nutritional status and adverse events of chemotherapy of breast cancer: a randomized, placebo-controlled, double-blind clinical trial. Indian J Pharm 45(3):217–222. https://doi.org/10.4103/0253-7613.111894
Vaz JA, Heleno SA, Martins A, Almeida GM, Vasconcelos MH, Ferreira IC (2010) Wild mushrooms Clitocybe alexandri and Lepista inversa: in vitro antioxidant activity and growth inhibition of human tumour cell lines. Food Chem Toxicol 48(10):2881–2884. https://doi.org/10.1016/j.fct.2010.07.021
Wan JM, SitWH, Louie JC (2008) Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol 32(3):689–699
Wang J, Xu B (2019) Targeted therapeutic options and future perspectives for HER2-positive breast cancer. Sig Transduct Target Ther 4:34. https://doi.org/10.1038/s41392-019-0069-2
Wang HX, Ng TB, Liu WK, Ooi VE, Chang ST (1996) Polysaccharide-peptide complexes from the cultured mycelia of the mushroom Coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages. Int J Biochem Cell Biol 28(5):601–607. https://doi.org/10.1016/1357-2725(95)00157-3
Wang CR, Ng TB, Li L, Fang JC, Jiang Y, Wen TY, Qiao WT, Li N, Liu F (2011) Isolation of a polysaccharide with antiproliferative, hypoglycemic, antioxidant and HIV-1 reverse transcriptase inhibitory activities from the fruiting bodies of the abalone mushroom Pleurotus abalonus. J Pharm Pharmacol 63(6):825–832. https://doi.org/10.1111/j.2042-7158.2011.01274.x
Wang D, Zhang Y, Lu J, Wang Y, Wang J, Meng Q, Lee RJ, Wang D, Teng L (2016) Cordycepin, a natural antineoplastic agent, induces apoptosis of breast cancer cells via caspase-dependent pathways. Nat Prod Commun 11(1):63–68
Wang KL, Lu ZM, Mao X, Chen L, Gong JS, Ren Y, Geng Y, Li H, Xu HY, Xu GH, Shi JS, Xu ZH (2019) Structural characterization and anti-alcoholic liver injury activity of a polysaccharide from Coriolus versicolor mycelia. Int J Biol Macromol 137:102–1111. https://doi.org/10.1016/j.ijbiomac.2019.06.242
Wong JH, Wang HX, Ng TB (2008) Marmorin, a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus. Appl Microbiol Biotechnol 81(4):669–674. https://doi.org/10.1007/s00253-008-1639-3
Wong JH, Ng TB, Wang H, Sze SC, Zhang KY, Li Q, Lu X (2011) Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine 18(5):387–392. https://doi.org/10.1016/ j.phymed.2010.07.010
Wong JH, Sze SCW, Ng TB, Cheung RCF, Tam C, Zhang KY, Dan X, Chan YS, Shing Cho WC, Ng CCW, Waye MMY, Liang W, Zhang J, Yang J, Ye X, Lin J, Ye X, Wang H, Liu F, Chan DW, Ngan HYS, Sha O, Li G, Tse R, Tse TF, Chan H (2018) Apoptosis and anti-cancer drug discovery: the power of medicinal fungi and plants. Curr Med Chem 25(40):5613–5630. https://doi.org/10.2174/0929867324666170720165005
Wu L, Wu Z, Lin Q, Xie L (2003) Purification and activities of an alkaline protein from mushroom Coprinus comatus. Wei Sheng Wu Xue Bao 43(6):793–798
Wu JY, Zhang QX, Leung PH (2007) Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanomain C57BL/6 mice. Phytomedicine. 14(1):43–49. https://doi.org/10.1016/j.phymed.2005.11.005
Wu G, Qian Z, Guo J, Hu D, Bao J, Xie J, Xu W, Lu J, Chen X, Wang Y (2012a) Ganoderma lucidum extract induces G1 cell cycle arrest, and apoptosis in human breast cancer cells. Am J Chin Med 40(3):631–642. https://doi.org/10.1142/S0192415X12500474
Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT (2012b) Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 83(2):408–414. https://doi.org/10.1016/j.fitote.2011.12.004
Wu GS, Song YL, Yin ZQ, Guo JJ, Wang SP, Zhao WW, Chen XP, Zhang QW, Lu JJ, Wang YT (2013) Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway. PLoS One 8(10):e76620. https://doi.org/10.1371/journal.pone.0076620
Xu DP, Zheng J, Zhou Y, Li Y, Li S, Li HB (2016a) Extraction of natural antioxidants from the Thelephora ganbajun mushroom by an ultrasound-assisted extraction technique and evaluation of antiproliferative activity of the extract against human cancer cells. Int J Mol Sci 17(10):E1664. https://doi.org/10.3390/ijms17101664
Xu H, Kong YY, Chen X, Guo MY, Bai XH, Lu YJ, Li W, Zhou XW (2016b) Recombinant FIP-gat, a fungal immunomodulatory protein from Ganoderma atrum, induces growth inhibition and cell death in breast cancer cells. J Agric Food Chem 64(13):2690–2698. https://doi.org/10.1021/acs.jafc.6b00539
Xu H, Zou S, Xu X (2017) The β-glucan from Lentinus edodes suppresses cell proliferation and promotes apoptosis in estrogen receptor positive breast cancers. Oncotarget 8(49):86693–86709. https://doi.org/10.18632/oncotarget.21411
Xue Z, Li J, Cheng A, Yu W, Zhang Z, Kou X, Zhou F (2015) Structure identification of triterpene from the mushroom Pleurotus eryngii with inhibitory effects against breast cancer. Plant Foods Hum Nutr 70(3):291–296. https://doi.org/10.1007/s11130-015-0492-7
Yamaguchi Y, Miyahara E, Hihara J. Efficacy and safety Yamaguchi Y, Miyahara E, Hihara J (2011) Efficacy and safety of orally administered Lentinula edodes mycelia extract for patients undergoing cancer chemotherapy: a pilot study. Am J patients undergoing cancer chemotherapy: a pilot study. Am J Chin Med 39(3):451–459. https://doi.org/10.1142/S0192415X1100895610.1142/S0192415X11008956
Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, Lin E, Lin WH, Hseu YC (2011) Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem Toxicol 49(1):290–298. https://doi.org/10.1016/j.fct.2010.10.031
Yang Q, Yin Y, Yu G, Jin Y, Ye X, Shrestha A, Liu W, Yu W, Sun H (2015) A novel protein with anti-metastasis activity on 4T1 carcinoma from medicinal fungus Cordyceps militaris. Int J Biol Macromol 80:385–391. https://doi.org/10.1016/j.ijbiomac.2015.06.050
Yang Y, Zhou H, Liu W, Wu J, Yue X, Wang J, Quan L, Liu H, Guo L, Wang Z, Lian X, Zhang Q (2018) Ganoderic acid A exerts antitumor activity against MDA-MB-231 human breast cancer cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 16(5):6515–6521. https://doi.org/10.3892/ol.2018.9475
Yap HY, Fung SY, Ng ST, Tan CS, Tan NH (2015) Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium. J Ethnopharmacol 174:437–451. https://doi.org/10.1016/j.jep.2015.08.042
Yap HY, Muria-Gonzalez MJ, Kong BH, Stubbs KA, Tan CS, Ng ST, Tan NH, Solomon PS, Fung SY, Chooi YH (2017) Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast. Microb Cell Fact 16(1):103. https://doi.org/10.1186/s12934-017-0713-x
Yap HYY, Tan NH, Ng ST, Tan CS, Fung SY (2018) Molecular attributes and apoptosis-inducing activities of a putative serine protease isolated from Tiger Milk mushroom (Lignosus rhinocerus) sclerotium against breast cancer cells in vitro. PeerJ. 6:e4940. https://doi.org/10.7717/peerj.4940
Yeung JH, Or PM (2011) Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes. Phytomedicine 18(13):1170–1175. https://doi.org/10.1016/j.phymed.2011.06.002
Yeung JH, Or PM (2012) Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes. Phytomedicine. 19(5):457–463. https://doi.org/10.1016/j.phymed.2011.09.077
Yi C, Fu M, Cao X, Tong S, Zheng Q, Firempong CK, Jiang X, Xu X, Yu J (2013a) Enhanced oral bioavailability and tissue distribution of a new potential anticancer agent, Flammulina velutipes sterols, through liposomal encapsulation. J Agric Food Chem 61(25):5961–5971. https://doi.org/10.1021/jf3055278
Yi C, Sun C, Tong S, Cao X, Feng Y, Firempong CK, Jiang X, Xu X, Yu J (2013b) Cytotoxic effect of novel Flammulina velutipes sterols and its oral bioavailability via mixed micellar nanoformulation. Int J Pharm 448(1):44–50. https://doi.org/10.1016/j.ijpharm.2013.03.020
Zaidman BZ, Wasser SP, Nevo E, Mahajna J (2008) Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells. Mol Biol Rep 35(2):107–117. https://doi.org/10.1007/s11033-007-9059-5
Zhang Y (2017) Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling. Biochem Biophys Res Commun 488(4):679–684. https://doi.org/10.1016/j.bbrc.2017.04.086
Zhang M, Chiu LC, Cheung PC, Ooi VE (2006) Growth-inhibitory effects of a beta-glucan from the mycelium of Poria cocos on human breast carcinoma MCF-7 cells: cell-cycle arrest and apoptosis induction. Oncol Rep 15(3):637–643
Zhang GQ, Sun J, Wang HX, Ng TB (2009a) A novel lectin with antiproliferative activity from the medicinal mushroom Pholiota adiposa. Acta Biochim Pol 56(3):415–421
Zhang M, Huang J, Xie X, Holman CD, Arcy J (2009b) Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women. Int J Cancer 124(6):1404–1408
Zhang G, Sun J, Wang H, Ng TB (2010a) First isolation and characterization of a novel lectin with potent antitumor activity from a Russula mushroom. Phytomedicine. 17(10):775–781. https://doi.org/10.1016/j.phymed.2010.02.001
Zhang RY, Zhang GQ, Hu DD, Wang HX, Ng TB (2010b) A novel ribonuclease with antiproliferative activity from fresh fruiting bodies of the edible mushroom Lyophyllum shimeiji. Biochem Genet 48(7-8):658–668. https://doi.org/10.1007/s10528-010-9347-y
Zhang M, Zhu L, Cui SW, Wang Q, Zhou T, Shen H (2011) Fractionation, partial characterization and bioactivity of water-soluble polysaccharides and polysaccharide-protein complexes from Pleurotus geesteranus. Int J Biol Macromol 48(1):5–12. https://doi.org/10.1016/j.ijbiomac.2010.09.003
Zhang Y, Liu Z, Ng TB, Chen Z, Qiao W, Liu F (2014) Purification and characterization of a novel antitumor protein with antioxidant and deoxyribonuclease activity from edible mushroom Pholiota nameko. Biochimie 99:28–37. https://doi.org/10.1016/j.biochi.2013.10.016
Zhang L, Khoo CS, Koyyalamudi SR, de Pedro N, Reddy N (2017a) Antioxidant, anti-inflammatory and anticancer activities of ethanol soluble organics from water extracts of selected medicinal herbs and their relation with flavonoid and phenolic contents. Pharmacologia 8:59–72. https://doi.org/10.5567/pharmacologia.2017.59.72
Zhang P, Li K, Yang G, Xia C, Polston JE, Li G, Li S, Lin Z, Yang LJ, Bruner SD, Ding Y (2017b) Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity. Proc Natl Acad Sci U S A 114(34):8980–8985. https://doi.org/10.1073/pnas.1706894114
Zhang M, Zhang Y, Zhang L, Tian Q (2019a) Mushroom polysaccharide lentinan for treating different types of cancers: a review of 12 years clinical studies in China. Prog Mol Biol Transl Sci 163:297–328. https://doi.org/10.1016/bs.pmbts.2019.02.013
Zhang Y, Jiang Y, Zhang M, Zhang L (2019b) Ganoderma sinense polysaccharide: An adjunctive drug used for cancer treatment. Prog Mol Biol Transl Sci 163:165–177. https://doi.org/10.1016/bs.pmbts.2019.02.008
Zhao S, Zhao Y, Li S, Zhao J, Zhang G, Wang H, Ng TB (2010) A novel lectin with highly potent antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the edible wild mushroom Russula delica. Glycoconj J 27(2):259–265. https://doi.org/10.1007/s10719-009-9274-5
Zhong K, Tong L, Liu L, Zhou X, Liu X, Zhang Q, Zhou S (2015) Immunoregulatory and antitumor activity of schizophyllan under ultrasonic treatment. Int J Biol Macromol 80:302–308. https://doi.org/10.1016/j.ijbiomac.2015.06.052
Zhou DH, Lin LZ (1995) Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi 15(8):476–478
Zhu-Salzman K, Hammen PK, Salzman RA, Hisashi Koiwa RA, Bressan L, Murdock L, Hasegawa PM (2002) Calcium modulates protease resistance and carbohydrate binding of a plant defense legume lectin, Griffonia simplicifolia lectin II (GSII). Comp Biochem Physiol B: Biochem Mol Biol 132(2):327–334
Zurrida S, Veronesi U (2015) Milestones in breast cancer treatment. Breast J 21(1):3. https://doi.org/10.1111/tbj.12361
Acknowledgments
We gratefully acknowledge the award of HMRF research grant (No. 12131221) from the Food and Health Bureau, the Government of Hong Kong Special Administrative Region, and a grant from the National Natural Science Foundation of China (No. 81471927). We are thankful for support of the science and technology project of the Science and Technology Innovation Commission of Shenzhen (No. JCYJ20170818094217688) and the discipline construction project of biochemistry and molecular biology from the National Development and Reform Commission (85629-000001 and 1452).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Ethical statement
This work does not contain any studies with human participants or animals performed by any of the authors.
Conflict of interest
The authors declare that they have no conflict of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Wong, J.H., Ng, T.B., Chan, H.H.L. et al. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol 104, 4675–4703 (2020). https://doi.org/10.1007/s00253-020-10476-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00253-020-10476-4