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Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials

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Abstract

Purpose

Oxidative stress (OS) is associated with several chronic complications and diseases. The use of coenzyme Q10 (CoQ10) as an adjuvant treatment with routine clinical therapy against metabolic diseases has shown to be beneficial. However, the impact of CoQ10 as a preventive agent against OS has not been systematically investigated.

Methods

A systematic literature search was performed using the PubMed, SCOPUS, EMBASE, and Cochrane Library databases to identify randomized clinical trials evaluating the efficacy of CoQ10 supplementation on OS parameters. Standard mean differences and 95% confidence intervals were calculated for net changes in OS parameters using a random-effects model.

Results

Seventeen randomized clinical trials met the eligibility criteria to be included in the meta-analysis. Overall, CoQ10 supplementation was associated with a statistically significant decrease in malondialdehyde (MDA) (SMD − 0.94; 95% CI − 1.46, − 0.41; I2 = 87.7%) and a significant increase in total antioxidant capacity (TAC) (SMD 0.67; 95% CI 0.28, 1.07; I2 = 74.9%) and superoxide dismutase (SOD) activity (SMD 0.40; 95% CI 1.12, 0.67; I2 = 9.6%). The meta-analysis found no statistically significant impact of CoQ10 supplementation on nitric oxide (NO) (SMD − 1.40; 95% CI − 0.12, 1.93; I2 = 92.6%), glutathione (GSH) levels (SMD 0.41; 95% CI − 0.09, 0.91; I2 = 70.0%), catalase (CAT) activity (SMD 0.36; 95% CI − 0.46, 1.18; I2 = 90.0%), or glutathione peroxidase (GPx) activities (SMD − 1.40; 95% CI: − 0.12, 1.93; I2 = 92.6%).

Conclusion

CoQ10 supplementation, in the tested range of doses, was shown to reduce MDA concentrations, and increase TAC and antioxidant defense system enzymes. However, there were no significant effects of CoQ10 on NO, GSH concentrations, or CAT activity.

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Authors and Affiliations

  1. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran

    Abolfazl Akbari & Shahram Agah

  2. Cellular & Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences (SkUMS), Shahrekord, Iran

    Gholam Reza Mobini

  3. Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mojgan Morvaridzadeh & Amirhossein Omidi

  4. Baylor Scott & White Research Institute, Dallas, Texas, USA

    Eric Potter

  5. Clinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran

    Siavash Fazelian

  6. Department of Anesthesiology and Critical Care, Shohadaye Tajrish Hospital, Tehran, Iran

    Seyed Hossein Ardehali

  7. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Elnaz Daneshzad

  8. Radiation Sciences Department, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

    Sadegh Dehghani

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  1. Abolfazl Akbari
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Table 2 Assessment of the risk of bias in the included studies
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Akbari, A., Mobini, G.R., Agah, S. et al. Coenzyme Q10 supplementation and oxidative stress parameters: a systematic review and meta-analysis of clinical trials. Eur J Clin Pharmacol 76, 1483–1499 (2020). https://doi.org/10.1007/s00228-020-02919-8

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