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Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation

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Abstract

Lung injury is a significant complication associated with cholestasis/cirrhosis. This problem significantly increases the risk of cirrhosis-related morbidity and mortality. Hence, finding effective therapeutic options in this field has significant clinical value. Severe inflammation and oxidative stress are involved in the mechanism of cirrhosis-induced lung injury. Taurine (TAU) is an abundant amino acid with substantial anti-inflammatory and antioxidative properties. The current study was designed to evaluate the role of TAU in cholestasis-related lung injury. For this purpose, bile duct ligated (BDL) rats were treated with TAU (0.5 and 1% w: v in drinking water). Significant increases in the broncho-alveolar lavage fluid (BALF) level of inflammatory cells (lymphocytes, neutrophils, basophils, monocytes, and eosinophils), increased IgG, and TNF-α were detected in the BDL animals (14 and 28 days after the BDL surgery). Alveolar congestion, hemorrhage, and fibrosis were the dominant pulmonary histopathological changes in the BDL group. Significant increases in the pulmonary tissue biomarkers of oxidative stress, including reactive oxygen species formation, lipid peroxidation, increased oxidized glutathione levels, and decreased reduced glutathione, were also detected in the BDL rats. Moreover, significant myeloperoxidase activity and nitric oxide levels were seen in the lung of BDL rats. It was found that TAU significantly blunted inflammation, alleviated oxidative stress, and mitigated lung histopathological changes in BDL animals. These data suggest TAU as a potential protective agent against cholestasis/cirrhosis-related lung injury.

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All data generated or analyzed during this study are included in this published article. Any supplementary data could be available from the corresponding author at reasonable request.

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Acknowledgements

The authors acknowledge the Pharmaceutical Sciences Research Center of Shiraz University of Medical Sciences for providing technical facilities for this investigation.

Funding

This study was financially supported by the Vice-Chancellor of Research Affairs of Shiraz University of Medical Sciences, Shiraz, Iran (grants #23701/23031/23040/23028/16428), Shanxi Agricultural University (Youth Fund project of Applied Basic Research in Shanxi Province; K272104065), and Natural Science Foundation of Shanxi Province (grant no. 201901D111232). Ali Mobasheri is supported by the Academy of Finland Profi6 336449 grant awarded to the University of Oulu, the European Commission, and the European Structural and Social Funds (ES Struktūrinės Paramos) awarded through the Research Council of Lithuania (Lietuvos Mokslo Taryba) and the funding program: Attracting Foreign Researchers for Research Implementation (2018–2022), grant no 01.2.2-LMT-K-718–02-0022.

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Authors and Affiliations

  1. College of Life Sciences, Shanxi Agricultural University, Taigu, 030801, Shanxi, China

    Mohammad Mehdi Ommati, Yanqin Ma, Dongmei Xu, Zhongwei Tang, Yu Lu, Hu Xin & Yang Mingyu

  2. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

    Mohammad Mehdi Ommati, Issa Sadeghian, Abolghasem Mousavifaraz, Ali Nadgaran, Ahmad Nikoozadeh, Sahra Mazloomi, Pooria Sayar Mehrabani, Mohammad Rezaei, Hossein Niknahad & Reza Heidari

  3. Physics, and Technology, Faculty of Medicine, Research Unit of Medical Imaging, University of Oulu, 90014, Oulu, Finland

    Ali Mobasheri

  4. Departments of Orthopedics, Rheumatology and Clinical Immunology, University Medical Center Utrecht, 3508 GA, Utrecht, The Netherlands

    Ali Mobasheri

  5. Department of Regenerative Medicine, State Research Institute Center for Innovative Medicine, 08406, Vilnius, Lithuania

    Ali Mobasheri

  6. Department of Biotechnology, GITAM Institute of Science, Gandhi Institute of Technology and Management, Visakhapatnam-530045, Andhra Pradesh, India

    Ram Kumar Manthari

  7. Food and Drug Administration, Iran Ministry of Health and Medical Education, Tehran, Iran

    Narges Abdoli

  8. Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

    Negar Azarpira, Abolghasem Mousavifaraz, Ali Nadgaran, Ahmad Nikoozadeh, Sahra Mazloomi, Pooria Sayar Mehrabani, Mohammad Rezaei & Hossein Niknahad

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  1. Mohammad Mehdi Ommati
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Contributions

M.M. Ommati, R. Heidari, H. Niknahad, RK Manthari, N. Azarpira, and A. Mobasheri were involved in subject conceptualization, funding acquisition, methodology, data analysis, validation, project administration, resources, and supervision, writing the original draft, and review and editing the manuscript. Y. Ma, D. Xu, Zh. Tang, Y. Lu, RK. Manthari, N. Abdoli, I. Sadeghian, A. Mousavifaraz, H. Xin, and Y. Mingyu were involved in data visualization, literature review, data analysis, and writing the original manuscript draft. I. Sadeghian, A. Mousavifaraz, A. Nadgaran, A. Nikoozadeh, S. Mazloomi, P. Mehrabani, M. Rezaei, N. Azarpira, and R. Heidari were involved in data collection. All authors read and approved the final version of the manuscript. The authors declare that all data were generated in-house, and no paper mill was used.

Corresponding authors

Correspondence to Hossein Niknahad or Reza Heidari.

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Competing interests

The authors declare no competing interests.

Ethics approval

All procedures using experimental animals were approved by the institutional ethics committee at Shiraz University of Medical Sciences, Shiraz, Iran (IR.SUMS.REC.1399.1353). This study does not include any human participants.

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Not applicable. This study contains no human data.

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Not applicable. This study contains no human data.

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Ommati, M.M., Mobasheri, A., Ma, Y. et al. Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation. Naunyn-Schmiedeberg's Arch Pharmacol 395, 1557–1572 (2022). https://doi.org/10.1007/s00210-022-02291-7

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