Abstract
Taurine (TAU) is the most abundant free amino acid in many tissues and in particular in proinflammatory cells like polymorphonuclear leukocytes and tissues exposed to elevated levels of oxidants1. Furthermore, orally administered TAU has been reported to reduce lung oxidant damage from exposure to ozone, nitrogen dioxide, paraquat, amiodarone and bleomycin in animal models2–5.
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References
Stapleton, P.P., O’Flaherty, L., Redmon, H.P., Bouchier-Hayes, D.J., 1998, Host defense — a role for the amino acid taurine?J. Parenter. Enteral Nutr.23: 366–367.
Schuller-Levis, G.B., Gordon, R.E., Park, E., Pendino, K.J., Laskin, D.L., 1995, Taurine protects rat bronchioles from acute ozone-induced lung inflammation and hyperplasia.Exp. Lung Res.21: 877–888.
Timbre, J.A., Seabra, V., Waterfield, C.J., 1995, The in vivo and in vitro protective properties of taurine.Gen. Pharmacol.26: 453–462.
Gordon, R.E., Park, E., Laskin, D., Schuller-Levis, G.B., 1998, Taurine protects rat bronchioles from acute ozone exposure: a freeze fracture and electron microscopic study.Exp. Lung Res.24: 659–674.
Gurujeyalakshmi, G., Wang, Y., Giri, S.N., 2000, Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-KB in mice.J. Pharmacol. Exp. Ther.293: 82–90.
Covarrubias, J., 1994, Taurine and the lung: Pharmacological intervention by aerosol route.Adv. Exp. Med. Biol.359: 413–417.
Barnes, P.J., 2000, Reactive oxygen species in asthma.Eur. Respir. Rev.10: 240–243.
Hofford, J.M., Milakofsky, L., Pell, S., Fish, J.E., Peters, S.P., Pollice, M., Vogel, W.H., 1997, Levels of amino acids and related compounds in bronchoalveolar lavage fluids of asthmatic patients. Am.J. Respir. Crit. Care Med.155: 432–435.
Hatzelmann A, Tenor H, Schudt C., 1995, Differential effects of non-selective phosphodiesterase inhibitors on human eosinophil functions.Br. J. Pharmacol114: 821–831
Cortijo J, Villagrasa V, Pons R, Berto L, Martí-Cabrera M, Martinez-Losa M, Domenech T, Beleta J, Morcillo EJ., 1999, Bronchodilator and anti-inflammatory activities of glaucine:In vitrostudies in human airway smooth muscle and polymorphonuclear leukocytes.Br. J. Pharmacol127: 1641–1651
Elwood, W., Barnes, P.J., Chung, K.F., 1992, Airway hyperresponsiveness is associated with inflammatory cell infiltration in allergic Brown-Norway rats.Int. Arch. Allergy Immunol.99: 91–97.
Liu, S.F., Haddad, E.B., Adcock, I., Salmon, M., Koto, H., Gilbey, T., Barnes, P.J., Chung, K.F., 1997, Inducible nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung.Br. J. Pharmacol.121: 1241–1246.
Schuller-Levis, G.B., Sturman, J.A., 1992, Activation of alveolar leukocytes isolated from cats fed taurine-free diets.Adv. Exp. Med. Biol.315: 83–90.
Cortijo,J.,Martí-Cabrera,M.,Pallardó, F.V., Esteras, A., Bruseghini, L., Viña, J., Morcillo, E.J., 1999, Contraction of human airways by oxidative stress. Protection by N-acetylcysteine.Free Rad. Biol. Med.27: 392–400.
Marcinkiewicz, J., Grabowska, A., Chain, B.M., 1998, Modulation of antigen-specific T-cell activation in vitro by taurine chloramine.Immunology94: 325–330.
Advenier, C., Mallard, B., Santais, M.C., Ruff, F., 1979, The effects of metiamide and H1receptor blocking agents on anaphylactic response in guinea-pigs.Agents Actions9: 467–473.
Kurachi, M., Hongoh, K., Watanabe, A., Aihara, H., 1987, Suppression of bronchial response to platelet activating factor following taurine administration.Adv. Exp. Med. Biol.217: 189–198.
Cortijo, J., Cerdá-Nicolás, M., Serrano, A., Bioque, G., Estrela, J.M., Santangelo, F., Esteras, A., Llombart-Bosch, A., Morcillo, E.J., 2001, Preventive effect of oral N-acetycysteine on bleomycin-induced lung injury.Eur. J. Resp. 17:1228–1235
Coleman, R.A., 1999, Current animal models are not predictive for clinical asthma.Pulm. Pharmacol. Then12: 87–89.
Cantin, A.M., 1994, Taurine modulation of hypochlorous acid-induced lung epithelial cell injury in vitro. Role of anion transport.J. Clin. Invest.93: 606–614.
Witko-Sarsat, V., Delacourt, C., Rabier, D., Bardet, J., Nguyen, A.T., Descamps-Latscha, B., 1995, Neutrophil-derived long-lived oxidants in cystic fibrosis sputum.Am. J. Respir. Crit. Care Med.152: 1910–1916.
Smith, L.J., Houston, M., Anderson, J., 1993, Increased levels of glutathione in bronchoalveolar lavage fluid from patients with asthma.Am. Rev. Respir. Dis.147: 1461–1464.
Cortijo J., Blesa S., Martinez-Losa M., Mata M., Seda E., Santangelo F., Morcillo E.J. 2001, Effects of taurine on pulmonary responses to antigen in sensitized Brown-Norway rat. Eur. J. Pharmacol. 413: 111–117
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Santangelo, F., Cortijo, J., Morcillo, E. (2003). Taurine and the Lung. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_49
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DOI: https://doi.org/10.1007/978-1-4615-0077-3_49
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