Summary
Axonal polyglucosan bodies in myelinated axons in the ventral posterolateral nucleus of the human thalamus (VPL) are described. These axonal inclusions were distributed exclusively in the dorsolateral part of the caudal VPL, and their arrangement may be associated with fibres originating from the gracile nucleus. They were not observed in patients under age of 50, and appeared to increase in number and size with advancing age. It is suggested that axonal polyglucosan bodies are an ageing phenomenon of the secondary sensory fibers.
Similar content being viewed by others
References
Anzil AP, Herrlinger H, Blinzinger K, Kronski D (1974) Intraneuritic corpora amylacea. Virchows Arch [A] 364:297–301
Boivie J (1978) Anatomical observations on the dorsal column nuclei, their thalamic projection and the cytoarchitecture of some somatosensory thalamic nuclei in the monkey. J Comp Neurol 178:17–48
Brannon W, McCormick W, Lampert P (1967) Axonal dystrophy in the gracile nucleus of man. Acta Neuropathol (Berl) 9:1–6
Defendini R, Markesber WR, Mastri AR, Duffy PE (1973) Hallervorden-Spatz disease and infantile neuroaxonal dystrophy. Ultrastructural observations, anatomical pathology and nosology. J Neurol Sci 20:7–23
Fujisawa K (1967) An unique type of axonal alteration (so-called axonal dystrophy) as seen in Goll's nucleus of 277 cases of controls. A contribution to the pathology of aging process. Acta Neuropathol (Berl) 8:255–275
Kalil K (1981) Projections of the cerebellar and dorsal column nuclei upon the thalamus of the rhesus monkey. J Comp Neurol 195:25–50
Ramsey HJ (1965) Ultrastructure of corpora amylacea. J Neuropathol Exp Neurol 24:25–39
Takahashi K, Agari M, Nakamura H (1975) Intra-axonal corpora amylacea in ventral and lateral horns of the spinal cord. Acta Neuropathol (Berl) 31:151–158
Takahashi K, Iwata K, Nakamura H (1977) Intra-axonal corpora amylacea in the CNS. Acta Neuropathol (Berl) 37: 165–167
Tracey DJ, Asanuma C, Jones EG, Porter R (1980) Thalamic relay to motor cortex: afferent pathways from brain stem, cerebellum, and spinal cord in monkeys. J Neurophysiol 44:532–553
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mizutani, T., Satoh, J. & Morimatsu, Y. Axonal polyglucosan body in the ventral posterolateral nucleus of the human thalamus in relation to ageing. Acta Neuropathol 74, 9–12 (1987). https://doi.org/10.1007/BF00688332
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688332