Summary
To determine how often Bunina bodies (BBs) appear in the medullary reticular formation (MRF) in amyotrophic lateral sclerosis (ALS), we microscopically examined 20 serial sections of MRFs from each of nine autopsied ALS cases, which had BBs in the lower motor neurons, including those of cranial motor nuclei. In 1 of them, the pontine tegmentum was examined in the same way. In 8 cases one to several BB-containing neurons in the MRF were seen. The case in which the pontine tegmentum was also investigated exhibited several neurons with BBs in this region. Some of the BBs in the MRFs were confirmed by electron microscopy. Thus, this study demonstrates the common appearance of BBs, although the number is small, in the MRF, indicating that pathological processes that undermine the lower motor neurons in ALS in some way also affect neurons other than motor neurons in this condition.
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References
Bunina TL (1962) On intracellular inclusions in familial amyotrophic lateral sclerosis. Korsakov J Neuropathol Psychiatry 62:1293–1299
Chou SM (1979) Pathognomy of intraneuronal inclusions in ALS. In: Japan Medical Research Association (ed) Amyotrophic lateral sclerosis. University of Tokyo Press, Tokyo, pp 135–176
Chou SM (1990) Neuropathology of upper motor neurons in amyotrophic lateral sclerosis. Proceedings of the XIth International Congress of Neuropathology, Kyoto, September 2–8, 1990, Japanese Society of Neuropathology, Kyoto, pp 595–599
Hart MN, Cancilla PA, Frommes S, Hirano A (1977) Anterior horn cell degeneration and Bunina-type inclusions associated with dementia. Acta neuropathol (Berl) 38:225–228
Hirano A (1965) Pathology of amyotrophic lateral sclerosis. In: Gajdusek DC, Gibbs CJ Jr (eds) Slow, latent, and temperate virus infections. NINDB Monograph, no. 2. NIH, Washingtin, pp23–37
Hirano A, Donnenfeld H, Sasaki S, Nakano I, Bartfeld H (1983) The fine structure of motor neurone disease. In: Rose FC (ed) Research progress in motor neurone disease. Pitman, London, pp328–348
Ikuta F, Makifuchi T, Ohama E, Takeda S, Oyanagi K, Nakashima S, Motegi T (1982) Tract degeneration of the human spinal cord: some observations on ALS and hemispherectomized humans. Adv Neurol Sci 26:710–736
Kato S, Hirano A (1992) Involvement of the brain stem reticular formation in familial amyotrophic lateral sclerosis. Clin Neuropathol 11:41–44
Mitsuyama Y (1984) Presenile dementia with motor neuron disease in Japan: clinico-pathological review of 26 cases. J Neurol Neurosurg Psychiatry 47:953–959
Nakano I (1992) Neuropathology of classical and several other types of amyotrophic lateral sclerosis. Brain Nerve (Tokyo) 44:495–503
Nakano I, Hirano A (1983) A neuropathological study of amyotropic lateral sclerosis. With special reference to central chromatolysis and spheroid in the spinal anterior horn and some pathological changes of the motor cortex. Neurol Med (Tokyo) 18:136–144
Nakano I, Hirano A, Kurland LT, Mulder DW, Holley PW, Saccomano G (1984) Familial amyotrophic lateral sclerosis. Neuropathology of two brothers in American “C” family. Neurol Med (Tokyo) 20:458–471
Nakano I, Hashizume Y, Tomonaga M (1990) Bunina bodies in neurons of the medullary reticular formation in a case of amyotrophic lateral sclerosis. Acta Neuropathol 79:689–691
Nakano I, Iwatsubo T, Hashizume Y, Mizutani T, Mannen T (1992) Amyotrophic lateral sclerosis with dementia-Lesions in the apical cortex and some deeper structures of the temporal lobes. Neuroapthology 12:69–77
Okamoto K, Yamazaki T, Yamaguchi H, Shoji M, Hirai S (1988) Pathology of Clarke's nucleus in sporadic amyotropic lateral sclerosis. Clin Neurol (Tokyo) 28:536–542
Okamoto K, Hirai S, Ishiguro K, Kawarabayashi T, Takatama M (1991) Light and electron microscopic and immunohistochemical observations of the Onuf's nucleus of amyotrophic lateral sclerosis. Acta neuropathol 81:610–614
Okamoto K, Hirai S, Shoji M, Harigaya Y, Fukuda T (1991) Widely distributed Bunina bodies and spheroids in a case of atypical sporadic amyotrophic lateral sclerosis. Acta Neuropathol 81:349–353
Smith MC (1960) Nerve fibre degeneration in the brain in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 23:269–282
Takahashi H, Ohama E, Ikuta F, Tokiguchi S (1991) An autopsy case of atypical motor neuron disease with Bunina bodies in the lower motor and subthalamic neurons. Acta Pathol Jpn 41:46–51
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Supported in part by the Research Committee of CNS Degenerative Diseases, the Ministry of Health and Welfare of Japan
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Nakano, I., Iwatsubo, T., Hashizume, Y. et al. Bunina bodies in neurons of the medullary reticular formation in amyotrophic lateral sclerosis. Acta Neuropathol 85, 471–474 (1993). https://doi.org/10.1007/BF00230484
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DOI: https://doi.org/10.1007/BF00230484