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Anti-fouling Medical Coatings

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Antimicrobial Coatings and Modifications on Medical Devices

Abstract

The medical device industry faces a ubiquitous threat of biofouling, generally leading to reduced efficacy or outright failure of implanted devices combined with increased healthcare cost. The use of polymers to make medical device surfaces nonadhesive to bacteria and other foulants in general is increasingly becoming a more attractive strategy in combatting this threat than active killing of bacteria. This chapter first introduces typical surface modification techniques that have been effectively used in medical devices, including physical adsorption, chemical attachment, chemical vapor deposition (CVD), and plasma-enhanced CVD. Then, specific anti-fouling surface chemistries and their respective anti-fouling mechanisms are overviewed, focusing on hydrophilic polymers, hydrophobic polymers, featured surfaces, and superhydrophobic surfaces. The current and potential medical applications of these anti-fouling modifications, in particular the distinctively versatile zwitterionic polybetaines, are therein also reviewed.

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Li, J., Taylor, M., Zhang, Z. (2017). Anti-fouling Medical Coatings. In: Zhang, Z., Wagner, V. (eds) Antimicrobial Coatings and Modifications on Medical Devices. Springer, Cham. https://doi.org/10.1007/978-3-319-57494-3_8

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