Skip to main content
SpringerLink
Log in

Phosphorylcholine Coating of ePTFE Grafts Reduces Neointimal Hyperplasia in Canine Model

  • Published:
Annals of Vascular Surgery

2

versus 0.53 ± 0.13 mm2, respectively; p= 0.008). Furthermore, the BrdU labeling index in the graft neointimal tissues was significantly smaller (p < 0.001) in the treated group (2.64 ± 0.77%) as compared with the control group (5.07 ± 0.83%). These data demonstrate that PC coating of ePTFE significantly reduces graft neointimal hyperplasia and cell proliferation in a canine carotid artery bypass model. The application of PC within the ePTFE graft effectively blocks tissue ingrowth from the adjacent native vessel, thereby preserving the anastomosis luminal diameter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Surgery, Emory University School of Medicine, Atlanta, GA, US

    Changyi Chen, Alan B. Lumsden, John C. Ofenloch & Beverly Noe

  2. Department of Medicine, Emory University School of Medicine, Atlanta, GA, US

    Stephen R. Hanson

  3. Cardiovascular Division, Biocompatibles Ltd, Farnham, Surrey, UK, GB

    Ewan J. Campbell, Peter W. Stratford, Yiannakis P. Yianni & Alistair S. Taylor

Authors
  1. Changyi Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alan B. Lumsden
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. John C. Ofenloch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Beverly Noe
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ewan J. Campbell
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Peter W. Stratford
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yiannakis P. Yianni
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Alistair S. Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Stephen R. Hanson
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Chen, C., Lumsden, A., Ofenloch, J. et al. Phosphorylcholine Coating of ePTFE Grafts Reduces Neointimal Hyperplasia in Canine Model . International Journal of Vascular Surgery 11, 74–79 (1997). https://doi.org/10.1007/s100169900013

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s100169900013

Search

Navigation