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Central Nervous System Leukemia

Prevention and Treatment

  • Book
  • © 1983

Overview

Editors:
  1. Renato Mastrangelo

    1. Clinica Pediatrica, Università Cattolica, Roma, Italy

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  2. David G. Poplack

    1. Pediatric Oncology Branch, National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Riccardo Riccardi

    1. Clinica Pediatrica, Università Cattolica, Roma, Italy

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Part of the book series: Developments in Oncology (DION, volume 13)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. The Pathology of Central Nervous System Leukemia

    • R. A. Price
    Pages 1-9

  3. Radiation Therapy Methods for Central Nervous System ‘Prophylaxis’ in the Management of Childhood Leukemias

    • G. J. D’Angio
    Pages 11-16

  4. Central Nervous System Prophylaxis for Therapy of Acute Lymphocytic Leukemia

    • A. M. Mauer, J. Ochs, W. P. Bowman, L. Ch’ien, W. Evans, R. Ragland et al.
    Pages 17-25

  5. Reduction in Central Nervous System Leukemia with a Pharmaco-kinetically derived Intrathecal-Methotrexate Dosage Regimen

    • W. A. Bleyer, C. Level, H. N. Sather, D. J. Niebrugge, P. F. Coccia, S. Siegel et al.
    Pages 27-37

  6. Central Nervous System Prophylaxis with Intermittent Intrathecal Methotrexate and Fractional Radiation in Childhood Acute Lymphoblastic Leukemia

    • Y. Ravindranath, K. Bhambhani, John K. Kelly, G. Schultz, I. Warrier, B. Considine et al.
    Pages 39-48

  7. Intermittent Intrathecal Methotrexate and Fractional Radiation plus Chemotherapy in Childhood Lymphoblastic Leukemia

    • R. Mastrangelo, R. Riccardi, R. Malandrino, A. Romanini
    Pages 49-52

  8. Prophylaxis of Central Nervous System Leukaemia: British Experience, 1970–80

    • R. M. Hardisty
    Pages 53-61

  9. The Norwegian Methotrexate Study in Childhood Acute Lymphocytic Leukemia

    • P. J. Moe, M. Seip, P. H. Finne, S. Kolmannskog
    Pages 63-69

  10. Therapy Related Central Nervous System Diseases in Children with Acute Lymphocytic Leukemia

    • R. A. Price
    Pages 71-81

  11. Neurotoxic Complications of CNS prophylaxis in Childhood Leukaemia

    • M. G. Mott
    Pages 83-93

  12. Evaluation of Adverse Sequelae of Central Nervous System Prophylaxis in Acute Lymphoblastic Leukemia

    • D. G. Poplack
    Pages 95-103

  13. Adverse Sequelae of Central Nervous System Prophylaxis in Acute Lymphoblastic Leukemia

    • G. Paolucci, P. Rosito
    Pages 105-112

  14. Treatment of Overt CNS Leukaemia

    • M. L. N. Willoughby
    Pages 113-122

  15. Radiation Therapy Methods for the Treatment of Central Nervous System Leukemia

    • A. Oakhill, G. J. D’angio
    Pages 123-130

  16. Treatment of Meningeal Leukemia: Investigation of New Approaches with Conventional Agents

    • R. Riccardi, D. G. Poplack
    Pages 131-136

  17. Back Matter

    Pages 137-139
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Keywords

About this book

In the past 10 to IS years there has been dramatic improvement in the survival of children with acute lymphoblastic leukemia. At the present time, over 50% of children with this disease will be alive and free of their disease at least 5 years from the time of their initial diagnosis. Although a number of factors have contributed to this improvement, perhaps none has been as important as the institution of central nervous system preventive therapy (eNS prophylaxis). However, despite the efficacy of eNS prophylaxis, the prevention and treatment of central nervous system leukemia continues to pose a formidable clinical challenge to the pediatric oncologist. Although successful in most cases, eNS preventive therapy remains ineffective for a small but significant subset of patients at high risk for developing eNS disease. Moreover, it has become increasingly evident that some methods of eNS preventive therapy are associated with long-term, adverse eNS sequelae. Thus, considerable controversy exists regarding the optimal method of eNS prophylaxis. Treatment of the patient who develops overt meningeal leukemia has not been as successful and continues to pose a major clinical challenge. Despite the ability of intrathecal chemotherapy and/or radiation therapy to induce eNS remission, most patients suffer subsequent relapse and ultimate survival is usually signifi­ cantly compromised. It is evident that newer approaches to treatment for this patient group must be identified before major improvement for this patient group is likely to occur.

Editors and Affiliations

  • Clinica Pediatrica, Università Cattolica, Roma, Italy

    Renato Mastrangelo, Riccardo Riccardi

  • Pediatric Oncology Branch, National Cancer Institute, Bethesda, USA

    David G. Poplack

Bibliographic Information

  • Book Title: Central Nervous System Leukemia

  • Book Subtitle: Prevention and Treatment

  • Editors: Renato Mastrangelo, David G. Poplack, Riccardo Riccardi

  • Series Title: Developments in Oncology

  • DOI: https://doi.org/10.1007/978-94-009-6708-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishers, Boston 1983

  • Softcover ISBN: 978-94-009-6710-6Published: 21 December 2011

  • eBook ISBN: 978-94-009-6708-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 152

  • Number of Illustrations: 15 b/w illustrations

  • Topics: Oncology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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