Skip to main content
SpringerLink
Log in

Urinary Dysfunction in Multiple System Atrophy

  • Reference work entry
  • First Online:
Handbook of Neurourology

  • 433 Accesses

Abstract

This chapter review summarized the epidemiology, pathophysiology, and management of bladder dysfunction in patients with multiple system atrophy (MSA). Since motor disorders in MSA often mimic those in Parkinson’s disease (PD), the different bladder disorders between these two diseases are worth considering; the identification of the specific bladder disorder aids the differential diagnosis of MSA, PD, and other MSA mimics. A bladder disorder is often the sole initial manifestation of MSA, and such patients see urologists or physicians first. Difficult emptying in MSA needs particular care at a neurology clinic. The collaboration of neurologists and urologists is highly recommended for the improvements of patients’ quality of life.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. R. Sakakibara, F. Tateno, T. Yamamoto, T. Uchiyama, T. Yamanishi, Urological dysfunction in synucleinopathies: epidemiology, pathophysiology and management. Clin. Auton. Res. 28, 83–101 (2018)

    Article  PubMed  Google Scholar 

  2. S. Gilman, G.K. Wenning, P.A. Low, D.J. Brooks, C.J. Mathias, J.Q. Trojanowski, N.W. Wood, C. Colosimo, A. Dürr, C.J. Fowler, H. Kaufmann, T. Klockgether, A. Lees, W. Poewe, N. Quinn, T. Revesz, D. Robertson, P. Sandroni, K. Seppi, M. Vidailhet, Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71, 670–676 (2008)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. A. Kikuchi, A. Takeda, N. Okamura, M. Tashiro, T. Hasegawa, S. Furumoto, et al., In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography in multiple system atrophy. Brain 133, 1772–1778 (2010)

    Article  PubMed  Google Scholar 

  4. F. Tateno, R. Sakakibara, T. Ogata, M. Kishi, Y. Tsuyusaki, O. Takahashi, M. Sugiyama, A. Tateno, Lower urinary tract function in dementia with Lewy bodies (DLB). Mov. Disord. 30, 411–415 (2015)

    Article  PubMed  Google Scholar 

  5. C.A. Cooper, L.M. Chahine, Biomarkers in prodromal Parkinson disease: A qualitative review. J. Int. Neuropsychol. Soc. 22, 956–967 (2016)

    Article  PubMed  Google Scholar 

  6. M. Stanzani-Maserati, R. Gallassi, G. Calandra-Buonaura, M. Alessandria, F. Oppi, R. Poda, L. Sambati, F. Provini, P. Cortelli, Cognitive and sleep features of multiple system atrophy: Review and prospective study. Eur. Neurol. 72, 349–359 (2014)

    Article  PubMed  Google Scholar 

  7. T. Ozawa, T. Revesz, D. Paviour, A.J. Lees, N. Quinn, M. Tada, A. Kakita, O. Onodera, K. Wakabayashi, H. Takahashi, M. Nishizawa, J.L. Holton, Difference in MSA phenotype distribution between populations: Genetics or environment? J. Parkinsons Dis. 2, 7–18 (2012)

    Article  CAS  PubMed  Google Scholar 

  8. T. Ogawa, R. Sakakibara, S. Kuno, O. Ishizuka, T. Kitta, N. Yoshimura, Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy. Nat. Rev. Urol. 14, 79–89 (2017)

    Article  CAS  PubMed  Google Scholar 

  9. R. Sakakibara, T. Uchiyama, T. Yamanishi, M. Kishi, Sphincter EMG as a diagnostic tool in autonomic disorders. Clin. Auton. Res. 19, 20–31 (2009)

    Article  PubMed  Google Scholar 

  10. T. Yamamoto, R. Sakakibara, T. Uchiyama, Z. Liu, T. Ito, Y. Awa, T. Yamanishi, T. Hattori, Questionnaire-based assessment of pelvic organ dysfunction in multiple system atrophy. Mov. Disord. 24, 972–978 (2009)

    Article  PubMed  Google Scholar 

  11. T. Yamamoto, R. Sakakibara, T. Uchiyama, C. Yamaguchi, F. Nomura, T. Ito, M. Yanagisawa, M. Yano, Y. Awa, T. Yamanishi, T. Hattori, S. Kuwabara, Pelvic organ dysfunction is more prevalent and severe in MSA-P compared to Parkinson’s disease. Neurourol. Urodyn. 30, 102–107 (2011)

    Article  CAS  PubMed  Google Scholar 

  12. R. Sakakibara, T. Hattori, T. Uchiyama, K. Kita, M. Asahina, A. Suzuki, T. Yamanishi, Urinary dysfunction and orthostatic hypotension in multiple system atrophy: Which is the more common and earlier manifestation? J. Neurol. Neurosurg. Psychiatry 68, 65–69 (2000)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. S. Gilman, S.J. May, C.W. Shults, C.M. Tanner, W. Kukull, V.M. Lee, E. Masliah, P. Low, P. Sandroni, J.Q. Trojanowski, L. Ozelius, T. Foroud, North American Multiple System Atrophy Study Group, The north American multiple system atrophy study group. J. Neural Transm. 112, 1687–1694 (2005)

    Article  CAS  PubMed  Google Scholar 

  14. R. Sakakibara, T. Hattori, T. Uchiyama, T. Yamanishi, Videourodynamic and sphincter motor unit potential analyses in Parkinson’s disease and multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 71, 600–606 (2001)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. M.D. Cykowski, E.A. Coon, S.Z. Powell, S.M. Jenkins, E.E. Benarroch, P.A. Low, A.M. Schmeichel, J.E. Parisi, Expanding the spectrum of neuronal pathology in multiple system atrophy. Brain 138, 2293–2309 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  16. T. Ito, R. Sakakibara, K. Nakazawa, T. Uchiyama, T. Yamamoto, Z. Liu, E. Shimizu, T. Hattori, Effects of electrical stimulation of the raphe area on the micturition reflex in cats. Neuroscience 142, 1273–1280 (2006)

    Article  CAS  PubMed  Google Scholar 

  17. R. Sakakibara, Y. Uchida, T. Uchiyama, T. Yamanishi, T. Hattori, Reduced cerebellar vermis activation in response to micturition in multiple system atrophy: 99mTc-labeled ECD SPECT study. Eur. J. Neurol. 11, 705–708 (2004)

    Article  CAS  PubMed  Google Scholar 

  18. T. Yamamoto, M. Asahina, Y. Yamanaka, T. Uchiyama, S. Hirano, M. Fuse, Y. Koga, R. Sakakibara, S. Kuwabara, The utility of post-void residual volume versus sphincter electromyography to distinguish between multiple system atrophy and Parkinson’s disease. PLoS One 12, e0169405 (2017). https://doi.org/10.1371/journal.pone.0169405. eCollection 2017

    Article  PubMed  PubMed Central  Google Scholar 

  19. T. Ito, R. Sakakibara, K. Yasuda, T. Yamamoto, T. Uchiyama, Z. Liu, T. Yamanishi, Y. Awa, K. Yamamoto, T. Hattori, Incomplete emptying and urinary retention in multiple-system atrophy: When does it occur and how do we manage it? Mov. Disord. 21, 816–823 (2006)

    Article  PubMed  Google Scholar 

  20. R. Sakakibara, C.J. Fowler, T. Hattori, I.F. Hussain, M.J. Swinn, T. Uchiyama, T. Yamanishi, Pressure-flow study as an evaluating method of neurogenic urethral relaxation failure. J. Auton. Nerv. Syst. 80, 85–88 (2000)

    Article  CAS  PubMed  Google Scholar 

  21. R. Sakakibara, T. Hattori, T. Uchiyama, T. Yamanishi, H. Ito, K. Ito, Neurogenic failures of the external urethral sphincter closure and relaxation; A videourodynamic study. Auton. Neurosci. 86, 208–215 (2001)

    Article  CAS  PubMed  Google Scholar 

  22. T. Yamamoto, R. Sakakibara, T. Uchiyama, Z. Liu, T. Ito, Y. Awa, T. Yamanishi, T. Hattori, Neurological diseases that cause detrusor hyperactivity with impaired contractile function. Neurourol. Urodyn. 25, 356–360 (2006)

    Article  PubMed  Google Scholar 

  23. H. Nakamura, R. Sakakibara, M. Sugiyama, F. Tateno, M. Yano, O. Takahashi, M. Kishi, Y. Tsuyusaki, H. Tateno, Y. Aiba, T. Ogata, T. Yamamoto, T. Yamanishi, T. Uchiyama, H. Suzuki, A. Tateno, Y. Suzuki, Neurologic diseases that cause female urinary retention. Bladder 3(1), e20 (2016). https://doi.org/10.14440/bladder.2016.70

    Article  Google Scholar 

  24. T.H. Yang, F.C. Chuang, H.C. Kuo, Urodynamic characteristics of detrusor underactivity in women with voiding dysfunction. PLoS One 13(6), e0198764 (2018). https://doi.org/10.1371/journal.pone.0198764. eCollection 2018.PMID: 29924821

  25. M. Sakuta, T. Nakanishi, Y. Toyokura, Anal muscle electromyograms differ in amyotrophic lateral sclerosis and Shy-Drager syndrome. Neurology 28, 1289–1293 (1978)

    Article  CAS  PubMed  Google Scholar 

  26. T. Yamamoto, R. Sakakibara, T. Uchiyama, C. Yamaguchi, F. Nomura, T. Ito, M. Yanagisawa, M. Yano, Y. Awa, T. Yamanishi, T. Hattori, S. Kuwabara, Receiver operating characteristic analysis of sphincter electromyography for parkinsonian syndrome. Neurourol. Urodyn. 31, 1128–1134 (2012)

    Article  PubMed  Google Scholar 

  27. D.C. Paviour, D.C. Williams, C.J. Fowler, N.P. Quinn, A.J. Lees, Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosis. Mov. Disord. 20, 1425–1430 (2005)

    Article  PubMed  Google Scholar 

  28. R. Sakakibara, T. Hattori, K. Kita, K. Arai, T. Yamanishi, K. Yasuda, Stress induced urinary incontinence in patients with spinocerebellar degeneration. J. Neurol. Neurosurg. Psychiatry 64, 389–391 (1998)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. T. Mashidori, T. Yamanishi, K. Yoshida, R. Sakakibara, K. Sakurai, K. Hirata, Continuous urinary incontinence presenting as the initial symptoms demonstrating acontractile detrusor and intrinsic sphincter deficiency in multiple system atrophy. Int. J. Urol. 14, 972–974 (2007)

    Article  PubMed  Google Scholar 

  30. O. Takahashi, R. Sakakibara, K. Tsunoyama, F. Tateno, M. Yano, M. Sugiyama, T. Uchiyama, T. Yamamoto, Y. Awa, C. Yamaguchi, T. Yamanishi, M. Kishi, Y. Tsuyuzaki, Do sacral/peripheral lesions contribute to detrusor-sphincter dyssynergia? LUTS 4, 126–129 (2012)

    Article  PubMed  Google Scholar 

  31. P.P. Pramstaller, G.K. Wenning, S.J.M. Smith, R.O. Beck, N.P. Quinn, C.J. Fowler, Nerve conduction studies, skeletal muscle EMG, and sphincter EMG in multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 580, 618–621 (1995)

    Article  Google Scholar 

  32. T. Yamamoto, R. Sakakibara, T. Uchiyama, C. Yamaguchi, S. Ohno, F. Nomura, M. Yanagisawa, T. Hattori, S. Kuwabara, Time-dependent changes and gender differences in urinary dysfunction in patients with multiple system atrophy. Neurourol. Urodyn. 33, 516–523 (2014)

    Article  PubMed  Google Scholar 

  33. C.J. Mathias, P. Fosbraey, D.F. DaCosta, A. Thornley, R. Bannister, The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure. BMJ 293, 353–356 (1986)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. R. Sakakibara, S. Matsuda, T. Uchiyama, M. Yoshiyama, T. Yamanishi, T. Hattori, The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria. Clin. Auton. Res. 13, 106–108 (2003)

    Article  PubMed  Google Scholar 

  35. R. Sakakibara, E. Murakami, A. Katagiri, S. Hayakawa, T. Uchiyama, T. Yamamoto, T. Hattori, Moxibustion, an alternative therapy, ameliorated disturbed circadian rhythm of plasma arginine vasopressin and urine output in multiple system atrophy. Intern. Med. 46, 1015–1018 (2007)

    Article  PubMed  Google Scholar 

  36. R. Sakakibara, T. Hattori, T. Uchiyama, T. Suenaga, H. Takahashi, T. Yamanishi, K. Egoshi, N. Sekita, Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte. J. Auton. Nerv. Syst. 79, 191–195 (2000)

    Article  CAS  PubMed  Google Scholar 

  37. R. Sakakibara, T. Uchiyama, M. Asahina, M. Yoshiyama, T. Yamanishi, T. Hattori, Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy. Clin. Auton. Res. 13, 51–53 (2003)

    Article  PubMed  Google Scholar 

  38. C.A. Donnellan, L. Fook, P. McDonald, J.R. Playfer, Oxybutynin and cognitive dysfunction. BMJ 315, 1363–1364 (1997)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. R. Sakakibara, H. Hamano, H. Yagi, Cognitive safety and overall tolerability of imidafenacin in clinical use: A long-term, open-label, post-marketing surveillance study. Low Urin. Tract Symptoms 6, 138–144 (2014)

    Article  PubMed  Google Scholar 

  40. G. Araklitis, D. Robinson, L. Cardozo, Cognitive effects of anticholinergic load in women with overactive bladder. Clin. Interv. Aging 15, 1493–1503 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. G.R. Mullen, S.A. Kaplan, Efficacy and safety of mirabegron in men with overactive bladder symptoms and benign prostatic hyperplasia. Curr. Urol. Rep. 22(1), 5 (2021). https://doi.org/10.1007/s11934-020-01017-7. PMID: 33411109

    Article  PubMed  Google Scholar 

  42. S. Herschorn, D. Staskin, C.R. Schermer, R.M. Kristy, A. Wagg, Safety and tolerability results from the PILLAR Study: A Phase IV, double-blind, randomized, placebo-controlled study of mirabegron in patients 65 years with overactive bladder-wet. Drugs Aging 37, 665–676 (2020)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. T. Yamamoto, R. Sakakibara, Y. Yamanaka, T. Uchiyama, M. Asahina, Z. Liu, T. Ito, Y. Koyama, Y. Awa, K. Yamamoto, M. Kinou, T. Hattori, Pyridostigmine in autonomic failure: Can we treat postural hypotension and bladder dysfunction with one drug? Clin. Auton. Res. 16, 296–298 (2006)

    Article  PubMed  Google Scholar 

  44. R. Sakakibara, J. Panicker, E. Finazzi-Agro, V. Iacovelli, H. Bruschini, Parkinson’s Disease Subcomittee, The Neurourology Promotion Committee in The International Continence Society, A guideline for the management of bladder dysfunction in Parkinson’s disease and other gait disorders. Neurourol. Urodyn. 35, 551–563 (2016)

    Article  PubMed  Google Scholar 

  45. T. Uchiyama, R. Sakakibara, M. Asahina, T. Yamanishi, T. Hattori, Post-micturitional hypotension in patients with multiple system atrophy. J. Neurol. Neurosurg. Psychiatry 76, 186–190 (2005)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. T. Komiyama, T. Hirokawa, K. Sato, A. Oka, H. Kamiguchi, E. Nagata, H. Sakura, K. Otsuka, H. Kobayashi, Relationship between human evolution and neutrally mediated syncope disclosed by the polymorphic sites of the adrenergic receptor gene α2B-AR. PLoS One 10, e0120788 (2015). https://doi.org/10.1371/journal.pone.0120788

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. E.A. Coon, D.M. Sletten, M.D. Suarez, J.N. Mandrekar, J.E. Ahlskog, J.H. Bower, J.Y. Matsumoto, M.H. Silber, E.E. Benarroch, R.D. Fealey, P. Sandroni, P.A. Low, W. Singer, Clinical features and autonomic testing predict survival in multiple system atrophy. Brain 138, 3623–3631 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  48. T. Xing, J. Ma, C. Jia, T. Ou, Neurogenic lower urinary tract dysfunction predicts prognosis in patients with multiple system atrophy. Clin. Auton. Res. 30, 247–254 (2020)

    Article  PubMed  Google Scholar 

  49. R. Sakakibara, J. Panicker, S. Simeoni, T. Uchiyama, T. Yamamoto, F. Tateno, M. Kishi, Y. Aiba, Bladder dysfunction as the initial presentation of multiple system atrophy: a prospective cohort study. Clin. Auton. Res. 29, 627–631 (2019)

    Article  PubMed  Google Scholar 

  50. J.N. Panicker, S. Simeoni, Y. Miki, A. Batla, V. Iodice, J.L. Holton, R. Sakakibara, T.T. Warner, Early presentation of urinary retention in multiple system atrophy: Can the disease begin in the sacral spinal cord? J. Neurol. 267, 659–664 (2020)

    Article  PubMed  Google Scholar 

  51. R. Sakakibara, J.N. Panicker, Y. Aiba, F. Tateno, T. Ogata, M. Yano, H. Suzuki, Y. Sugisaki, A. Shimizu, O. Takahashi, S. Simeoni, Possible “premotor” multiple system atrophy-cerebellar form. Eur. Neurol. 83, 80–86 (2020)

    Article  PubMed  Google Scholar 

  52. F. Tateno, R. Sakakibara, M. Kishi, T. Yuasa, E. Ogawa, O. Takahashi, S. Yoshio, M. Sugiyama, T. Uchiyama, T. Yamamoto, T. Yamanishi, Progressive supranuclear palsy presenting with urinary retention and sleep apnea. Clin. Auton. Res. 21, 173–175 (2011)

    Article  PubMed  Google Scholar 

  53. T. Yamamoto, F. Tateno, R. Sakakibara, S. Furukawa, M. Asahina, T. Uchiyama, S. Hirano, Y. Yamanaka, M. Fuse, Y. Koga, M. Yanagisawa, S. Kuwabara, Urinary dysfunction in progressive supranuclear palsy compared with other parkinsonian disorders. PLoS One 11(2), e0149278 (2016). https://doi.org/10.1371/journal.pone.0149278. eCollection 2016.PMID: 26886104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. E. Indelicato, A. Fanciulli, J.P. Ndayisaba, W. Nachbauer, R. Granata, J. Wanschitz, M. Wagner, E.R. Gizewski, W. Poewe, G.K. Wenning, S. Boesch, Autonomic function testing in spinocerebellar ataxia type 2. Clin. Auton. Res. 28, 341–346 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  55. R. Sakakibara, T. Uchiyama, K. Arai, T. Yamanishi, T. Hattori, Lower urinary tract dysfunction in Machado-Joseph disease: a study of 11 clinical-urodynamic observations. J. Neurol. Sci. 218, 67–72 (2004)

    Article  PubMed  Google Scholar 

  56. A.F. Musegante, P.N. Almeida, A.L. Barboza, U. Barroso Jr., Urinary symptoms and urodynamic findings in patients with Machado-Joseph disease. J. Neurol. 258, 623–666 (2011)

    Article  CAS  PubMed  Google Scholar 

  57. R. Hanna Al-Shaikh, A.I. Wernick, A.J. Strongosky, A.I. Soto-Beasley, J.A. van Gerpen, W.P. Cheshire, R.J. Uitti, O.A. Ross, Z.K. Wszolek, Spinocerebellar ataxia type 6 family with phenotypic overlap with multiple system atrophy. Neurol. Neurochir. Pol. 54, 350–355 (2020)

    Article  PubMed  Google Scholar 

  58. F. Tateno, R. Sakakibara, M. Sugiyama, M. Kishi, E. Ogawa, O. Takahashi, M. Yano, T. Uchiyama, T. Yamamoto, Y. Tsuyuzaki, Lower urinary tract function in spinocerebellar ataxia 6. Low Urin. Tract Symptoms 4, 41–44 (2012)

    Article  PubMed  Google Scholar 

  59. M. Jang, H.J. Kim, A. Kim, B. Jeon, Urinary symptoms and urodynamic findings in patients with spinocerebellar ataxia. Cerebellum 19, 483–486 (2020)

    Article  CAS  PubMed  Google Scholar 

  60. K. Kanai, R. Sakakibara, T. Uchiyama, Z. Liu, T. Yamamoto, T. Ito, S. Hirano, M. Asahina, S. Kuwabara, T. Hattori, G. Fukami, K. Arai, C. Yamaguchi, F. Nomura, Sporadic case of spinocerebellar ataxia type 17: treatment observations for managing urinary and psychotic symptoms. Mov. Disord. 22, 441–443 (2007)

    Article  PubMed  Google Scholar 

  61. M. Sugiyama, R. Sakakibara, F. Tateno, M. Yano, O. Takahashi, M. Kishi, Y. Tsuyusaki, T. Yamamoto, T. Uchiyama, T. Yamanishi, C. Yamaguchi, F. Nomura, Voiding dysfunction in spinocerebellar ataxia type 31. Low Urin Tract Symptoms. 6, 64–67 (2014)

    Article  CAS  PubMed  Google Scholar 

  62. F. Tateno, R. Sakakibara, Y. Aiba, T. Ogata, Alcoholism mimicking multiple system atrophy: a case report. Clin. Auton. Res. 30, 581–584 (2020)

    Article  PubMed  Google Scholar 

  63. I. Stankovic, N. Quinn, L. Vignatelli, A. Antonini, D. Berg, E. Coon, P. Cortelli, A. Fanciulli, J.J. Ferreira, R. Freeman, G. Halliday, G.U. Höglinger, V. Iodice, H. Kaufmann, T. Klockgether, V. Kostic, F. Krismer, A. Lang, J. Levin, P. Low, C. Mathias, W.G. Meissner, L.N. Kaufmann, J.A. Palma, J.N. Panicker, M.T. Pellecchia, R. Sakakibara, J. Schmahmann, S.W. Scholz, W. Singer, M. Stamelou, E. Tolosa, S. Tsuji, K. Seppi, W. Poewe, G.K. Wenning, Movement Disorder Society multiple system atrophy study group. A critique of the second consensus criteria for multiple systematrophy. Mov. Disord. 34, 975–984 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  64. M.T. Pellecchia, I. Stankovic, A. Fanciulli, F. Krismer, W.G. Meissner, J.A. Palma, J.N. Panicker, K. Seppi, G.K. Wenning, Members of the Movement Disorder Society multiple system atrophy study group. Can autonomic testing and imaging contribute to the early diagnosis of multiple system atrophy? A systematic review and recommendations by the Movement Disorder Society Multiple System Atrophy Study Group. Mov. Disord. Clin. Pract. 7, 750–762 (2020)

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan

    Ryuji Sakakibara, Fuyuki Tateno, Tatsuya Yamamoto & Tomoyuki Uchiyama

  2. Neurology, Chiba Prefectural University of Health Sciences, Chiba, Japan

    Tatsuya Yamamoto

Authors
  1. Ryuji Sakakibara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fuyuki Tateno
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tatsuya Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tomoyuki Uchiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ryuji Sakakibara .

Editor information

Editors and Affiliations

  1. Department of Urology Department of Neurourology, China Rehabiliation Research Center China Rehabilitation Science InstituteCapital Medical University, Beijing, China

    Limin Liao

  2. Department of Urology, Medical University Innsbruck, University Hospital, Innsbruck, Austria

    Helmut Madersbacher

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Singapore Pte Ltd.

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Sakakibara, R., Tateno, F., Yamamoto, T., Uchiyama, T. (2023). Urinary Dysfunction in Multiple System Atrophy. In: Liao, L., Madersbacher, H. (eds) Handbook of Neurourology. Springer, Singapore. https://doi.org/10.1007/978-981-99-1659-7_65

Download citation

  • DOI: https://doi.org/10.1007/978-981-99-1659-7_65

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-99-1658-0

  • Online ISBN: 978-981-99-1659-7

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation