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Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy

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Abstract.

In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %, p < 0.05). Amezinium metilsulfate most probably stimulates both α1B-receptors in the vascular wall and α1A/D-receptors in the proximal urethra.

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Authors and Affiliations

  1. Department of Neurology, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan. sakaki@med.m.chiba-u.ac.jp, , , , , , JP

    Ryuji Sakakibara, Tomoyuki Uchiyama, Masato Asahina, Mitsuharu Yoshiyama & Takamichi Hattori

  2. Department of Urology, Dokkyo Medical College, Tochigi, Japan, , , , , , JP

    Tomonori Yamanishi

Authors
  1. Ryuji Sakakibara
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  2. Tomoyuki Uchiyama
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  3. Masato Asahina
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  4. Mitsuharu Yoshiyama
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  5. Tomonori Yamanishi
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  6. Takamichi Hattori
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Correspondence to Ryuji Sakakibara, MD

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Sakakibara, R., Uchiyama, T., Asahina, M. et al. Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy. Clin Auton Res 13, 51–53 (2003). https://doi.org/10.1007/s10286-003-0034-5

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  • DOI: https://doi.org/10.1007/s10286-003-0034-5

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