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The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria

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Abstract.

Nocturnal waking in urination (nocturia) is a common feature in patients with multiple system atrophy (MSA). Degeneration of arginine vasopressin (AVP) neurons in the suprachiasmatic nucleus in this disorder may lead to nocturnal polyuria, which has been treated with intramuscular desmopressin. We also prescribed 5 μg of intranasal desmopressin once a night in 3 MSA patients, who had nocturnal polyuria with abnormal circadian rhythm of the plasma AVP. During the treatment, all patients showed an improvement in their nocturia without serious adverse effects.

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Authors and Affiliations

  1. Neurology Department, Chiba University, 1-8-1 Inohana Chuo-Ku, Chiba 260-8670, Japan. sakaki@med.m.chiba-u.ac.jp, , , , , , JP

    Ryuji Sakakibara, Shinji Matsuda, Tomoyuki Uchiyama, Mitsuharu Yoshiyama & Takamichi Hattori

  2. Department of Urology, Dokkyo Medical College, Japan, , , , , , JP

    Tomonori Yamanishi

Authors
  1. Ryuji Sakakibara
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  2. Shinji Matsuda
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  3. Tomoyuki Uchiyama
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  4. Mitsuharu Yoshiyama
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  5. Tomonori Yamanishi
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  6. Takamichi Hattori
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Additional information

Received: 16 October 2001, Accepted: 4 June 2002

Correspondence to: Ryuji Sakakibara

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Sakakibara, R., Matsuda, S., Uchiyama, T. et al. The effect of intranasal desmopressin on nocturnal waking in urination in multiple system atrophy patients with nocturnal polyuria. Clin Auton Res 13, 106–108 (2003). https://doi.org/10.1007/s10286-003-0052-3

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  • DOI: https://doi.org/10.1007/s10286-003-0052-3

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