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Glutamine–Fructose-6-Phosphate Transaminase 1,2 (GFPT1,2)

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Handbook of Glycosyltransferases and Related Genes

Abstract

l-Glutamine–d-fructose-6-phosphate transaminase (GFPT) is the first and rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP). GFPT converts d-fructose-6-phosphate (Fru-6-P) and l-glutamine to d-glucosamine-6-phosphate (GlcN-6-P) and l-glutamate. GlcN-6-P is an essential precursor of hexosamines, such as uridine 5′-diphosphate-N-acetyl-d-glucosamine (UDP-GlcNAc). UDP-GlcNAc is a substrate for synthesis of glycoproteins, proteoglycans, and glycolipids and moreover for the posttranslational modification of proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) on serine and threonine residues, which is an important step for the regulation of intracellular signaling. Figure 129.1 is a schematic representation of the HBP, which includes the synthesis of GlcNAcylated proteins.

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Authors and Affiliations

  1. Tsukuba Research Laboratories, Eisai Co., Ltd, 5-1-3, Tokodai, 300-2635, Tsukuba, Ibaraki, Japan

    Dr. Kazuto Yamazaki

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  1. Dr. Kazuto Yamazaki
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Correspondence to Kazuto Yamazaki .

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Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Yamazaki, K. (2014). Glutamine–Fructose-6-Phosphate Transaminase 1,2 (GFPT1,2). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_154

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