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Table of contents

  1. Front Matter
    Pages 1-38
  2. Glucosyltransferases

    1. Front Matter
      Pages 1-1
    2. Yoshio Hirabayashi, Yohei Ishibashi
      Pages 3-13
    3. Armando J. Parodi, Julio J. Caramelo, Cecilia D’Alessio
      Pages 15-30
    4. Takashi Sato, Hisashi Narimatsu
      Pages 31-38
    5. Hideyuki Takeuchi, Robert S. Haltiwanger
      Pages 39-47
  3. Galactosyltransferases

    1. Front Matter
      Pages 49-49
    2. Boopathy Ramakrishnan, Pradman K. Qasba
      Pages 51-62
    3. Malene Bech Vester-Christensen, Lars Hansen, Henrik Clausen
      Pages 73-80
    4. Koichi Furukawa, Yuhsuke Ohmi, Keiko Furukawa
      Pages 81-88
    5. Malene Bech Vester-Christensen, Lars Hansen, Henrik Clausen
      Pages 101-108
    6. Dale Christiansen, Effie Mouhtouris, Mauro S. Sandrin
      Pages 121-129
    7. Koichi Furukawa, Yuji Kondo, Keiko Furukawa
      Pages 141-147
  4. Mannosyltransferases

    1. Front Matter
      Pages 171-171
    2. Hiroshi Manya, Tamao Endo
      Pages 173-179
  5. N-Acetylglucosaminyltransferases

    1. Front Matter
      Pages 181-181
    2. James W. Dennis, Naoyuki Taniguchi, Michael Pierce
      Pages 233-246
    3. Kei-ichiro Inamori, Michael Pierce, Naoyuki Taniguchi
      Pages 247-255
    4. Akira Togayachi, Hisashi Narimatsu
      Pages 283-294
    5. Jiunn-Chern (Gene) Yeh, Minoru Fukuda
      Pages 295-302
    6. Akira Togayachi, Hisashi Narimatsu
      Pages 303-310
    7. Akira Togayachi, Hisashi Narimatsu
      Pages 337-345
  6. N-Acetylgalactosaminyltransferases

    1. Front Matter
      Pages 415-415
    2. Koichi Furukawa, Keiko Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Yoshio Yamauchi, Noboru Hashimoto et al.
      Pages 417-428
    3. Kiyohiko Angata, Takashi Sato, Akira Togayachi, Hisashi Narimatsu
      Pages 439-445

About this book

Introduction

This handbook, now in a new, second edition, is an essential resource for scientists with an interest in the role of glycosyltransferases and related genes involved in the biosynthesis of glycoproteins, glycolipids, and proteoglycans.

The first edition of the Handbook of Glycosyltransferases and Related Genes, published in 2002, contained descriptions of more than 100 mammalian genes by over 100 scientists who originally isolated and/or cloned these genes. Since then, there has been a growing body of evidence concerning the roles of glycosyltransferases, and additional glycosyltransferases have been identified. Now more than 200 glycosyltransferases have been isolated from mammalian tissue, corresponding to approximately 1–2% of the total human genome. Some have been found to be involved in development and reproduction, signal transduction, cell death, higher nervous functioning, immunity, and other important biological processes. Glycosyltransferases have also been implicated in the development of lifestyle diseases such as diabetes, cancer, chronic obstructive lung disease (COPD), neuromuscular diseases, and infectious diseases.

A functional glycomics approach using gene targeting in mice and analytical methods utilizing glycan arrays, lectin arrays, HPLC, and mass spectrometry identified the target glycoprotein(s) on which glycans are attached by the catalytic reaction of glycosyltransferases. Most of the target proteins have been shown to be cell surface membrane proteins such as growth factor receptors and transporters. The three-dimensional structures of some glycosyltransferases have also been characterized, making it possible to classify them into retaining and inverting enzymes. Such structural information is also included in this invaluable new edition.

Editors and affiliations

  • Naoyuki Taniguchi
    • 1
  • Koichi Honke
    • 2
  • Minoru Fukuda
    • 3
  • Hisashi Narimatsu
    • 4
  • Yoshiki Yamaguchi
    • 5
  • Takashi Angata
    • 6
  1. 1.RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKENWakoJapan
  2. 2.Department of BiochemistryKochi University, Medical SchoolNankokuJapan
  3. 3.Sanford Burnham Medical Research InstituteLa JollaUSA
  4. 4.Research Center for Medical Glycoscience (RCMG)National Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan
  5. 5.RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKENWakoJapan
  6. 6.Institute of Biological ChemistryAcademia SinicaTaipeiTaiwan

Bibliographic information