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Grapevine Stilbenoids: Bioavailability and Neuroprotection

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Natural Products

Abstract

Vine and wine are an abundant source of stilbenoids that constitute a large class of compounds, including a series of monomers and oligomers (dimers, trimers, tetramers). Stilbenoids can reach a level of over 100 mg L−1 in red wine. Several epidemiological studies have correlated the consumption of grapes and wines with significant health benefits. The most studied stilbenoid, resveratrol, exhibits multiple biological activities across multiple diseases including cancer and cardiovascular and neurodegenerative diseases. This compound shows promise in both the prevention and the treatment of these diseases. Moreover, resveratrol mimics calorie restriction and extends the lifespan in species ranging from yeast to multicellular animals (not in normal mammals) by a sirtuin-dependent mechanism. Resveratrol is well absorbed yet rapidly metabolized; however, the tissue concentrations found in some studies in animals and humans are compatible with its biological activities. Resveratrol is well tolerated at doses of up to 1 g day−1 in human and does not cause serious adverse events up to 5 g day−1. Interestingly, other wine and grape stilbenoids such as piceatannol, pterostilbene, viniferins, and vitisins also have beneficial activities. In this chapter, we have discussed chemistry and protective role of stilbenoids in general, and resveratrol in particular, during various pathological conditions such as neurodegeneration, neuroinflammation, cancer, cardiovascular diseases, and antiaging process. Works related to bioavailability and clinical trials of resveratrol are also presented.

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Abbreviations

AA:

Arachidonic acid

AD:

Alzheimer’s disease

ADI:

Acceptable daily intake

AP-1:

Activator protein 1

APP:

Amyloid precursor protein

Aβ:

β-Amyloid peptide

COX:

Cyclooxygenase

HDL:

High-density lipoprotein

IGF:

Insulin-like growth factor

IL:

Interleukin

iNOS:

Inductible nitric oxide synthase

LDL:

Low-density lipoprotein

LPS:

Lipopolysaccharide

MAPK:

Mitogen-activated protein kinase

NF-κB:

Nuclear factor-kappa B

NO:

Nitric oxide

NOAEL:

No observed adverse effect levels

PGE2 :

Prostaglandin E2

ROS:

Reactive oxygen species

SIRT:

Sirtuin

TNF:

Tumor necrosis factor

TxA2:

Thromboxane A2

References

  1. Waterhouse AL, Teissèdre PL (1997) In: Watkins TR (ed) Wine nutritional and therapeutic benefits, vol 661, ACS symposium series. Washington, p 12

    Google Scholar 

  2. Renaud S, De Lorgeril M (1992) Lancet 339:1523

    Article  CAS  Google Scholar 

  3. Renaud S, Guégen R, Schenker J, D’Houtaud A (1998) Epidemiology 9:184

    Article  CAS  Google Scholar 

  4. Renaud S, Guéguen R, Siest G, Salomon R (1999) Arch Intern Med 159:1865

    Article  CAS  Google Scholar 

  5. Gronbaek M, Becker U, Johansen D, Gottschau A, Schnohr P, Hein HO, Jensen G, Sorensen T (2000) Ann Intern Med 133:411

    Article  CAS  Google Scholar 

  6. Mukamal KJ, Kuller LH, Fitzpatrick A, Longstreth WT, Mittleman MA, Siscovick DS (2003) J Am Med Assoc 289:1405

    Article  CAS  Google Scholar 

  7. Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F (2005) N Engl J Med 352:245

    Article  CAS  Google Scholar 

  8. Dufouil C, Ducimetiere P, Alperovitch A (1997) Am J Epidemiol 146:405

    Article  CAS  Google Scholar 

  9. Arntzen KA, Schirmer H, Wilsgaard T, Mathiesen EB (2010) Acta Neurol Scand 122:23

    Article  Google Scholar 

  10. Orgogozo JM, Dartigues JF, Lafont S, Letenneur L, Commenges D, Salamon R, Renaud S, Breteler MB (1997) Rev Neurol 153:185

    CAS  Google Scholar 

  11. Truelsen T, Thudium D, Gronbaek M (2002) Neurology 59:1313

    Article  Google Scholar 

  12. Deng J, Zhou DHD, Li J, Wang YJ, Gao C, Chen M (2006) Clin Neurol Neurosurg 108:378

    Article  Google Scholar 

  13. Lindsay J, Laurin D, Verreault R, Hébert R, Helliwell B, Hill GB, McDowell I (2002) Am J Epidemiol 156:445

    Article  Google Scholar 

  14. Luchsinger JA, Tang MX, Siddiqui M, Shea S, Mayeux R (2004) J Am Geriatr Soc 52:540

    Article  Google Scholar 

  15. Johansen D, Friis K, Skovenborg E, Gronbaek M (2006) Br Med J 332:519

    Article  Google Scholar 

  16. Yeung SLA, Jiang C, Zhang W, Lam TH, Cheng KK, Leung GM, Schooling CM (2010) Ann Epidemiol 20:873

    Article  Google Scholar 

  17. Corley J, Jia X, Brett CE, Gow AJ, Starr JM, Kyle JAM, McNeill G, Deary IJ (2011) Neuropsychology 25:166

    Article  Google Scholar 

  18. Kikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA (2010) Br J Nutr 103:730

    Article  CAS  Google Scholar 

  19. Shen T, Wang XN, Lou HX (2009) Nat Prod Rep 26:916

    Article  CAS  Google Scholar 

  20. Mattivi F, Reniero F, Korhammer S (1995) J Agric Food Chem 43:1820

    Article  CAS  Google Scholar 

  21. Pawlus AD, Waffo-Téguo P, Mérillon JM (2012) J Int Sci Vigne Vin 45:57

    Google Scholar 

  22. Guerrero R, Puertas B, Fernández M (2010) Innov Food Sci Emerg Technol 11:231

    Article  CAS  Google Scholar 

  23. Mattivi F, Vrhovsek U, Malacarne G, Masuero D, Zulini L, Stefanini M, Moser C, Velasco R, Guella G (2011) J Agric Food Chem 59:5364

    Article  CAS  Google Scholar 

  24. Pezet R, Pont V (1988) Plant Physiol Biochem 26:603

    CAS  Google Scholar 

  25. Bavaresco L, Pezzutto S, Gatti M, Mattivi F (2007) Vitis 46:57

    Google Scholar 

  26. Langcake P, Cornford C, Pryce R (1979) Phytochemistry 18:1025

    Article  CAS  Google Scholar 

  27. Jeandet P, Breuil AC, Adrian M, Weston LA, Debord S, Meunier P, Maune G, Bessis R (1997) Anal Chem 69:5172

    Article  CAS  Google Scholar 

  28. Douillet-Breuil AC, Jeandet P, Adrian M, Bessis R (1999) J Agric Food Chem 47:4456

    Article  CAS  Google Scholar 

  29. Zga N, Papastamoulis Y, Toribio A, Richard T, Delaunay JC, Jeandet P, Renault JH, Monti JP, Mérillon JM, Waffo-Téguo P (2009) J Chromatogr B 877:1000

    Article  CAS  Google Scholar 

  30. Delaunay JC, Castagnino C, Chèze C, Vercauteren J (2002) J Chromatogr A 964:123

    Article  CAS  Google Scholar 

  31. Kong Q, Ren X, Jiang L, Pan Y, Sun C (2010) J Sci Food Agric 90:823

    CAS  Google Scholar 

  32. Richard T, Poupard P, Papastamoulis Y, Monti JP (2010) In: Georges A, Cheynier V, Lefer P, Sarni-Manchado P (eds) Polyphenols communications 2010, Montpellier, vol 2, p 423

    Google Scholar 

  33. Ito J, Takaya Y, Oshima Y, Niwa M (1999) Tetrahedron 55:2529

    Article  CAS  Google Scholar 

  34. Yan KX, Terashima K, Takaya Y, Niwa M (2001) Tetrahedron 57:2711

    Article  CAS  Google Scholar 

  35. Barjot C, Tournaire M, Castagnino C, Vigor C, Vercauteren J, Rossi JF (2007) Life Sci 81:1565

    Article  CAS  Google Scholar 

  36. Takaya Y, Terashima K, Yan K, Niwa M (2003) Heterocycles 60:1433

    Article  CAS  Google Scholar 

  37. Yan KX, Terashima K, Takaya Y, Niwa M (2002) Tetrahedron 58:6931

    Article  CAS  Google Scholar 

  38. Ito J, Niwa M (1996) Tetrahedron 52:9991

    Article  CAS  Google Scholar 

  39. Reniero F, Rudolph M, Angioni A, Bernreuther A, Cabras P, Mattivi F (1996) Vitis 35:125

    CAS  Google Scholar 

  40. Siemann EH, Creasy LL (1992) Am J Enol Vitic 43:49

    CAS  Google Scholar 

  41. Goldberg D, Yan J, Ng E, Diamandis E, Karumanchiri A, Soleas G, Waterhouse A (1995) Am J Enol Vitic 46:159

    CAS  Google Scholar 

  42. Jeandet P, Bessis R, Maume B, Meunier P, Peyron D, Trollat P (1995) J Agric Food Chem 43:316

    Article  CAS  Google Scholar 

  43. Lamuela-Raventós RM, Waterhouse AL (1993) J Agric Food Chem 41:521

    Article  Google Scholar 

  44. Vitrac X, Castagnino C, Waffo-Téguo P, Delaunay JC, Vercauteren J, Monti JP, Deffieux G, Mérillon JM (2001) J Agric Food Chem 49:5934

    Article  CAS  Google Scholar 

  45. Feijóo O, Moreno A, Falqué E (2008) J Food Compost Anal 21:608

    Article  CAS  Google Scholar 

  46. Lamuela-Raventos RM, Romero-Pérez AN, Waterhouse AL, de la Torre-Boronat MC (1995) J Agric Food Chem 43:281

    Article  CAS  Google Scholar 

  47. Ribeiro de Lima MT, Waffo-Téguo P, Teissèdre PL, Pujolas A, Vercauteren J, Cabanis JC, Mérillon JM (1999) J Agr Food Chem 47:2666

    Article  Google Scholar 

  48. Baderschneider B, Winterhalter P (2000) J Agric Food Chem 48:2681

    Article  CAS  Google Scholar 

  49. Vitrac X, Monti J, Vercauteren J, Deffieux G, Mérillon J (2002) Anal Chem Acta 458:103

    Article  CAS  Google Scholar 

  50. Vitrac X, Bornet A, Vanderlinde R, Valls J, Richard T, Delaunay JC, Mérillon JM, Teissédre PL (2005) J Agric Food Chem 53:5664

    Article  CAS  Google Scholar 

  51. Guebailia HA, Chira K, Richard T, Mabrouk T, Furiga A, Monti JP, Delaunay JC, Mérillon JM (2006) J Agric Food Chem 54:9559

    Article  CAS  Google Scholar 

  52. Boutegrabet L, Fekete A, Hertkorn N, Papastamoulis Y, Waffo-Téguo P, Mérillon JM, Jeandet P, Gougeon RD, Schmitt-Kopplin P (2011) Anal Bioanal Chem 401:1517

    Article  CAS  Google Scholar 

  53. Buiarelli F, Coccioli F, Jasionowska R, Merolle M, Terracciano A (2007) Rapid Commun Mass Spectrom 21:2955

    Article  CAS  Google Scholar 

  54. Pezet R, Cuenat P (1996) Am J Enol Vitic 47:287

    CAS  Google Scholar 

  55. Ritchie K, Lovestone S (2002) Lancet 360:1759

    Article  Google Scholar 

  56. Mucke L (2009) Nature 461:895

    Article  CAS  Google Scholar 

  57. Sisodia SS, Price DL (1995) FASEB J 9:366

    CAS  Google Scholar 

  58. Selkoe DJ (2001) Physiol Rev 81:741

    CAS  Google Scholar 

  59. Pereira C, Agostinho P, Moreira PI, Cardoso SM, Oliveira CR (2005) Curr Drug Targets CNS Neurol Disord 4:383

    Article  CAS  Google Scholar 

  60. Anekonda TS (2006) Brain Res Rev 52:316

    Article  CAS  Google Scholar 

  61. Giunta B, Fernandez F, Nikolic WV, Obregon D, Rrapo E, Town T, Tan J (2008) J Neuroinflamm 5:51

    Article  CAS  Google Scholar 

  62. Anekonda TS, Quinn JF, Harris C, Frahler K, Wadsworth TL, Woltjer RL (2011) Neurobiol Dis 41:62

    Article  CAS  Google Scholar 

  63. Yates D, McLoughlin DM (2007) Psychiatry 7:1

    Article  Google Scholar 

  64. Blurton-Jones M, LaFerla FM (2006) Curr Alzheimer Res 3:437

    Article  CAS  Google Scholar 

  65. Small SA, Duff K (2008) Neuron 60:534

    Article  CAS  Google Scholar 

  66. Wang J, Ho L, Zhao W, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM (2006) FASEB J 20:2313

    Article  CAS  Google Scholar 

  67. Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow DB, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL, Pasinetti GM (2009) J Alzheimers Dis 16:59

    CAS  Google Scholar 

  68. Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen LH, Humala N, Teplow DB, Pasinetti GM (2008) J Neurosci 28:6388

    Article  CAS  Google Scholar 

  69. Jang JH, Surh YJ (2003) Free Radic Biol Med 34:1100

    Article  CAS  Google Scholar 

  70. Han YS, Zheng WH, Bastianetto S, Chabot JG, Quirion R (2004) Br J Pharmacol 141:997

    Article  CAS  Google Scholar 

  71. Kim HJ, Lee KW, Lee HJ (2007) Ann N Y Acad Sci 1095:473

    Article  CAS  Google Scholar 

  72. Zhang F, Liu J, Shi JS (2010) Eur J Pharmacol 636:1

    Article  CAS  Google Scholar 

  73. Jang MH, Piao XL, Kim HY, Cho EJ, Baek SH, Kwon SW, Park JH (2007) Biol Pharm Bull 30:1130

    Article  CAS  Google Scholar 

  74. Marambaud P, Zhao PH, Davies P (2005) J Biol Chem 280:37377

    Article  CAS  Google Scholar 

  75. Jeon SY, Kwon SH, Seong YH, Bae K, Hur JM, Lee YY, Suh DY, Song KS (2007) Phytomedicine 14:403

    Article  CAS  Google Scholar 

  76. Golde TE (2006) J Neurochem 99:689

    Article  CAS  Google Scholar 

  77. Ono K, Hasegawa K, Naiki H, Yamada M (2004) J Neurosci Res 75:742

    Article  CAS  Google Scholar 

  78. Rivière C, Richard T, Quentin L, Krisa S, Mérillon JM, Monti JP (2007) Bioorg Med Chem 15:1160

    Article  CAS  Google Scholar 

  79. Zou JG, Wang ZR, Huang YZ, Cao KJ, Wu JM (2003) Int J Mol Med 11:317

    CAS  Google Scholar 

  80. Rivière C, Delaunay JC, Immel F, Cullin C, Monti JP (2009) Neurochem Res 34:1120

    Article  CAS  Google Scholar 

  81. Rivière C, Papastamoulis Y, Fortin PY, Delchier N, Waffo-Teguo P, Kapche GD, Delaunay JC, Mérillon JM, Richard T, Monti JP (2010) Bioorg Med Chem Lett 20:3441

    Article  CAS  Google Scholar 

  82. Richard T, Pawlus AD, Iglesias ML, Pedrot E, Waffo-Teguo P, Mérillon JM, Monti JP (2011) Ann N Y Acad Sci 1215:103

    Article  CAS  Google Scholar 

  83. Richard T, Poupard P, Nassra M, Papastamoulis Y, Iglesias ML, Krisa S, Waffo-Teguo P, Mérillon JM, Monti JP (2011) Bioorg Med Chem 19:3152

    Article  CAS  Google Scholar 

  84. Karuppagounder S, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE (2009) Neurochem Int 54:111

    Article  CAS  Google Scholar 

  85. Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH (2003) Neuron 40:471

    Article  CAS  Google Scholar 

  86. Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH (2006) J Neurosci 26:10536

    Article  CAS  Google Scholar 

  87. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH (2007) EMBO J 26:3169

    Article  CAS  Google Scholar 

  88. Ransohoff RM, Perry VH (2009) Annu Rev Immunol 27:119

    Article  CAS  Google Scholar 

  89. Zielasek J, Hartung HP (1996) Adv Neuroimmunol 6:191

    Article  CAS  Google Scholar 

  90. Giulian D (1999) Neurochem Int 65:13

    CAS  Google Scholar 

  91. Block ML, Hong JS (2005) Prog Neurobiol 76:77

    Article  CAS  Google Scholar 

  92. Jin CY, Moon DO, Lee KJ, Kim MO, Lee JD, Choi YH, Park YM, Kim GY (2006) Pharmacol Res 54:461

    Article  CAS  Google Scholar 

  93. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD (2002) J Neurosci 22:3484

    CAS  Google Scholar 

  94. Kang J, Park EJ, Jou I, Kim JH, Joe EH (2001) Neuroreport 12:1449

    Article  CAS  Google Scholar 

  95. Lorenz P, Roychowdhury S, Engelmann M, Wolf G, Horn TFW (2003) Nitric Oxide 9:64

    Article  CAS  Google Scholar 

  96. Bi XL, Yang JY, Dong YX, Wang JM, Cui YH, Ikeshima T, Zhao YQ, Wu CF (2005) Int Immunopharmacol 5:185

    Article  CAS  Google Scholar 

  97. Meng XL, Yang JY, Chen GL, Wang LH, Zhang LJ, Wang S, Li J, Wu CF (2008) Chem Biol Interact 174:51

    Article  CAS  Google Scholar 

  98. Candelario-Jalil E, de Oliveira ACP, Gräf S, Bhatia HS, Hüll M, Munoz E, Fiebich BL (2007) J Neuroinflamm 4:25

    Article  CAS  Google Scholar 

  99. Sung MJ, Davaatseren M, Kim W, Park SK, Kim SH, Hur HJ, Kim MS, Kim YS, Kwon DY (2009) Int Immunopharmacol 9:319

    Article  CAS  Google Scholar 

  100. Abraham J, Johnson RW (2009) Rejuvenation Res 12:445

    Article  CAS  Google Scholar 

  101. Blanco-Colio LM, Munoz-Garcia B, Martin-Ventura JL, Alvarez-Sala LA, Castilla M, Bustamante A, Lamuela-Raventos RM, Gomez-Gerique J, Fernandez-Cruz A, Millan J, Egido J (2007) Atherosclerosis 192:335

    Article  CAS  Google Scholar 

  102. Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, Sun AY (2002) Brain Res 958:439

    Article  CAS  Google Scholar 

  103. Kumar A, Naidu PS, Seghal N, Padi SSV (2007) Pharmacology 79:17

    Article  CAS  Google Scholar 

  104. Williams LD, Burdock GA, Edwards JA, Beck M, Bausch J (2009) Food Chem Toxicol 47:2170

    Article  CAS  Google Scholar 

  105. Horn TL, Cwik MJ, Morrissey RL, Kapetanovic I, Crowell JA, Booth TD, McCormick DL (2007) Food Chem Toxicol 45:55

    Article  CAS  Google Scholar 

  106. Crowell JA, Korytko PJ, Morrissey RL, Booth TD, Levine BS (2004) Toxicol Sci 82:614

    Article  CAS  Google Scholar 

  107. Gehm BD, McAndrews JM, Chien PY, Jameson JL (1997) Proc Natl Acad Sci USA 94:14138

    Article  CAS  Google Scholar 

  108. Edwards JA, Beck M, Riegger C, Bausch J (2011) Ann N Y Acad Sci 1215:131

    Article  CAS  Google Scholar 

  109. Elliott PJ, Walpole S, Morelli L, Lambert PD, Lunsmann W, Westphal CH, Lavu S (2009) Drugs Future 34:291

    Article  CAS  Google Scholar 

  110. Cottard CH, Nivet-Antoine V, Laguiller-Morizot C, Beaudeux JL (2010) Mol Nutr Food Res 54:7

    Article  CAS  Google Scholar 

  111. Boocock DJ, Faust GES, Patel KR, Schinas AM, Brown VA, Ducharme MP, Booth TD, Crowell JA, Perloff M, Gescher AJ, Steward WP, Brenner DE (2007) Cancer Epidemiol Biomarkers Prev 16:1246

    Article  CAS  Google Scholar 

  112. Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE (2010) Cancer Res 70:9003

    Article  CAS  Google Scholar 

  113. Chow HHS, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS (2010) Cancer Prev Res 3:1168

    Article  CAS  Google Scholar 

  114. Bertelli AA, Giovannini L, Stradi R, Bertelli A, Tillement JP (1996) Int J Tissue React 18:67

    CAS  Google Scholar 

  115. Andlauer W, Kolb J, Siebert K, Fürst P (2000) Drugs Exp Clin Res 26:47

    CAS  Google Scholar 

  116. Aumont V, Krisa S, Battaglia E, Netter P, Richard T, Mérillon JM, Magdalou J, Sabolovic N (2004) J Biotechnol 109:287

    Article  CAS  Google Scholar 

  117. Soleas GJ, Yan J, Goldberg DM (2001) Methods Enzymol 335:130

    Article  CAS  Google Scholar 

  118. Vitrac X, Desmoulière A, Brouillaud B, Krisa S, Deffieux G, Barthe N, Rosenbaum J, Mérillon JM (2003) Life Sci 72:2219

    Article  CAS  Google Scholar 

  119. Juan ME, Maijó M, Planas JM (2010) J Pharm Biomed Anal 51:391

    Article  CAS  Google Scholar 

  120. Soleas GJ, Angelini M, Grass L, Diamandis EP, Golberg DM (2001) Methods Enzymol 335:145

    Article  CAS  Google Scholar 

  121. Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004) Drug Metab Dispos 32:1377

    Article  CAS  Google Scholar 

  122. Boocock DJ, Patel KR, Faust GE, Normolle DP, Marczylo TH, Crowell JA, Brenner DE, Booth TD, Gescher A, Steward WP (2007) J Chromatogr B Analyt Technol Biomed Life Sci 848:182

    Article  CAS  Google Scholar 

  123. Burkon A, Somoza V (2008) Mol Nutr Food Res 52:549

    Article  CAS  Google Scholar 

  124. Golberg DM, Yan J, Soleas GJ (2003) Clin Biochem 36:79

    Article  CAS  Google Scholar 

  125. La Porte C, Voduc N, Zhang G, Seguin I, Tardiff D, Singhal N, Cameron DW (2010) Clin Pharmacokinet 49:449

    Article  Google Scholar 

  126. Abd El-Mohsen M, Bayele H, Kuhnle G, Gibson G, Debnam E, Kaila Srai S, Rice-Evans C, Spencer JP (2006) Br J Nutr 96:62

    Article  CAS  Google Scholar 

  127. Patel KR, Brown VA, Jones DJL, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowel JA, Brenner DE, Steward WP, Gescher AJ, Brown K (2010) Cancer Res 70:7392

    Article  CAS  Google Scholar 

  128. Hoshino J, Park EJ, Kondratyuk TP, Marler L, Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M (2010) J Med Chem 53:5033

    Article  CAS  Google Scholar 

  129. Calamini B, Ratia K, Malkowski MG, Cuendet M, Pezzuto JM, Santarsiero BD, Mesecar AD (2010) Biochem J 429:273

    Article  CAS  Google Scholar 

  130. Mikulski D, Molski M (2010) Eur J Med Chem 45:2366

    Article  CAS  Google Scholar 

  131. Clifford AJ, Ebeler SE, Ebeler JD, Bills ND, Hinrichs SH, Teissèdre PL (1996) Am J Clin Nutr 64:748

    CAS  Google Scholar 

  132. Baur JA, Sinclair DA (2006) Nat Rev 5:493

    Article  CAS  Google Scholar 

  133. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CWW, Fong HHS, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997) Science 275:218

    Article  CAS  Google Scholar 

  134. Ndiaye M, Philippe C, Mukhtar H, Ahmad N (2011) Arch Biochem Biophys 508:164

    Article  CAS  Google Scholar 

  135. Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (2009) Arch Biochem Biophys 486:95

    Article  CAS  Google Scholar 

  136. Ohyama M, Tanaka T, Ito T, Iinuma M, Bastow KF, Lee KH (1999) Bioorg Med Chem Lett 9:3057

    Article  CAS  Google Scholar 

  137. Kimura Y, Baba K, Okuda H (2000) Anticancer Res 20:2923

    CAS  Google Scholar 

  138. Wieder T, Prokop A, Bagci B, Essmann F, Bernicke D, Schulze-Osthoff K, Dörken B, Schmalz HG, Daniel PT, Henze G (2001) Leukemia 15:1735

    Article  CAS  Google Scholar 

  139. Billard C, Izard JC, Roman V, Kern C, Mathiot C, Mentz F, Kolb JP (2002) Leuk Lymphoma 43:1991

    Article  CAS  Google Scholar 

  140. Mishima S, Matsumoto K, Futamura Y, Araki Y, Ito T, Tanaka T, Iinuma M, Nozawa Y, Akao Y (2003) J Exp Ther Oncol 3:283

    Article  CAS  Google Scholar 

  141. Ito T, Akao Y, Yi H, Ohguchi K, Matsumoto K, Tanaka T, Iinuma M, Nozawa Y (2003) Carcinogenesis 24:1489

    Article  CAS  Google Scholar 

  142. Liu BL, Inami Y, Tanaka H, Inagaki N, Iinuma M, Nagai H (2004) Chin J Nat Med 2:176

    CAS  Google Scholar 

  143. Tolomeo M, Grimaudo S, Di Cristina A, Roberti M, Pizzirani D, Meli M, Dusonchet L, Gebbia N, Abbadessa V, Crosta L, Baruchello R, Grisolia G, Invidiata F, Simoni D (2005) IntJ Biochem Cell Biol 37:1709

    Article  CAS  Google Scholar 

  144. Chowdhury SA, Kishino K, Satoh R, Hashimoto K, Kikuchi H, Nishikawa H, Shirataki Y, Sakagami H (2005) Anticancer Res 35:2055

    Google Scholar 

  145. Colin D, Lancon A, Delmas D, Lizard G, Abrossinow J, Kahn E, Jannin B, Latruffe N (2008) Biochimie 90:1674

    Article  CAS  Google Scholar 

  146. Jang M, Pezzuto JM (1999) Drug Exp Clin Res 25:65

    CAS  Google Scholar 

  147. Delmas D, Lançon A, Colin D, Jannin B, Latruffe N (2006) Curr Drug Targets 7:1

    Article  Google Scholar 

  148. Goswani SK, Das DK (2009) Cancer Lett 284:1

    Article  CAS  Google Scholar 

  149. Bishayee A (2009) Cancer Prev Res 2:409

    Article  CAS  Google Scholar 

  150. Lin HY, Lansing L, Mérillon JM, Davis FB, Tang HY, Shih A, Vitrac X, Krisa S, Keating T, Cao HJ, Bergh J, Quackenbush S, Davis PJ (2006) FASEB J 20:1742

    Article  CAS  Google Scholar 

  151. Godichaud S, Krisa S, Couronné B, Dubuisson L, Mérillon JM, Desmoulière A, Rosenbaum J (2000) Hepatology 31:922

    Article  CAS  Google Scholar 

  152. Bishayee A, Politis T, Darvesh AS (2010) Cancer Treat Rev 36:43

    Article  CAS  Google Scholar 

  153. Li Y, Wicha MS, Schawrtz SJ, Sun D (2011) J Nutr Biochem 22:799

    Google Scholar 

  154. Piver B, Fer M, Vitrac X, Merillon JM, Berthou F, Dreano Y, Lucas D (2004) Biochem Pharmacol 68:773

    Article  CAS  Google Scholar 

  155. Potter GA, Patterson LH, Wanagho E, Perry PJ, Butler PC, Ijaz T, Ruparelia KC, Lamb JH, Farmer PB, Stanley LA, Burke MD (2002) Br J Cancer 86:774

    Article  CAS  Google Scholar 

  156. Geahlen RL, McLaughlin JL (1989) Biochem Biophys Res Commun 165:241

    Article  CAS  Google Scholar 

  157. Dang O, Navarro L, David M (2004) Shock 21:470

    Article  CAS  Google Scholar 

  158. Richard N, Porath D, Radspieler A, Schwager J (2005) Mol Nutr Food Res 49:431

    Article  CAS  Google Scholar 

  159. Ashikawa K, Majumdar S, Banerjee S, Barthi AC, Shishodia S, Aggarwal BB (2002) J Immunol 169:6490

    CAS  Google Scholar 

  160. Kwon GT, Jung JIJ, Song HR, Woo EY, Jun JG, Kim JK, Her S, Park JHY (2012) J Nutr Biochem 23:228

    Google Scholar 

  161. Piver B, Berthou F, Dreano Y, Lucas D (2003) Life Sci 73:1199

    Article  CAS  Google Scholar 

  162. Do QT, Renimel I, André P, Lugnier C, Muller CD, Bernard P (2005) Curr Drug Discov Technol 2:161

    Article  CAS  Google Scholar 

  163. Huang HS, Lin M, Cheng GF (2001) Phytochemistry 58:357

    Article  CAS  Google Scholar 

  164. Liu BL, Inami Y, Tanaka H, Inagaki N, Iinuma M, Nagai H (2004) Chin J Nat Med 2:176

    CAS  Google Scholar 

  165. Fulda S (2010) Drug Discov Today 15:757

    Article  CAS  Google Scholar 

  166. Saiko P, Szakmary A, Jaeger W, Szekeres T (2008) Mutat Res 658:68

    Article  CAS  Google Scholar 

  167. Delmas D, Jannin B, Latruffe N (2005) Mol Nutr Food Res 49:377

    Article  CAS  Google Scholar 

  168. Leifert WR, Abeywardena MY (2008) Nutr Res 28:729

    Article  CAS  Google Scholar 

  169. Ross R (1993) Nature 362:801

    Article  CAS  Google Scholar 

  170. Waffo Téguo P, Fauconneau B, Deffieux G, Huguet F, Vercauteren J, Mérillon JM (1998) J Nat Prod 61:655

    Article  Google Scholar 

  171. Cheng JC, Fang JG, Chen WF, Zhou B, Yang L, Liu ZL (2006) Bioorg Chem 34:142

    Article  CAS  Google Scholar 

  172. Frémont L (2000) Life Sci 66:663

    Article  Google Scholar 

  173. Ijima K, Yoshizumi M, Hashimoito M, Kim S, Eto M, Ako J, Liang YQ, Sudoh N, Hosoda K, Nakahara K, Toba K, Ouchi Y (2000) Circulation 101:805

    Article  Google Scholar 

  174. Brito PM, Devillard R, Salvayre AN, Almeida LM, Dinis TCP, Salvayre R, Augé N (2009) Atherosclerosis 205:126

    Article  CAS  Google Scholar 

  175. Park ES, Lim Y, Hong JT, Yoo HS, Lee CK, Pyo MY, Yun YP (2010) Vasc Pharmacol 53:61

    Article  CAS  Google Scholar 

  176. Ong ET, Hwang TL, Huang YL, Lin CF, Wu WB (2011) Toxicol Appl Pharmacol 256:198

    Google Scholar 

  177. Auger C, Teissèdre PL, Gérain P, Lequeux N, Bornet A, Serisier S, Besançon P, Caporiccio B, Cristol JP, Rouanet JM (2005) J Agric Food Chem 53:2015

    Article  CAS  Google Scholar 

  178. Penumathsa SV, Koneru S, Samuel SM, Maulik G, Bagchi D, Yet SF, Menon VP, Maulik N (2008) Free Radic Biol Med 45:1027

    Article  CAS  Google Scholar 

  179. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM (1995) Clin Chim Acta 235:207

    Article  CAS  Google Scholar 

  180. Varache-Lembège M, Waffo Teguo P, Richard T, Monti JP, Deffieux G, Vercauteren J, Mérillon JM, Nuhrich A (2000) Med Chem Res 10:253

    Google Scholar 

  181. Huang YL, Tsai WJ, Shen CC, Chen CC (2005) J Nat Prod 68:217

    Article  CAS  Google Scholar 

  182. Stef G, Csiszar A, Lerea K, Ungvari Z, Veress G (2006) J Cardiovasc Pharmacol 48:1

    Article  CAS  Google Scholar 

  183. Cox DA, Cohen ML (1996) Pharmacol Rev 48:3

    CAS  Google Scholar 

  184. Schmitt CA, Dirsch VM (2009) Nitric Oxide 21:77

    Article  CAS  Google Scholar 

  185. Gresele P, Cerletti C, Gulielmini G, Pignatelli P, de Gaetano G, Violi F (2011) J Nutr Biochem 22:201

    Article  CAS  Google Scholar 

  186. Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, Forstermann U (2002) Circulation 106:1652

    Article  CAS  Google Scholar 

  187. Liu JC, Chen JJ, Chan P, Cheng CF, Cheng TH (2003) Hypertension 42:1198

    Article  CAS  Google Scholar 

  188. Zou JG, Wang ZR, Huang YZ, Cao KJ, Wu JM (2003) Int J Mol Med 11:317

    CAS  Google Scholar 

  189. Stoclet JC, Chataigneau T, Ndiaye M, Oak MH, Bedoui JE, Chataigneau M, Chini-Kerth VB (2004) Eur J Pharmacol 500:299

    Article  CAS  Google Scholar 

  190. Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Karantzoglou G, Magiatis P, Skaltsounis AL, Kremastinos DT (2005) Eur J Cardiovasc Prev Rehabil 12:596

    Article  Google Scholar 

  191. Hung LM, Su MJ, Chu WK, Chiao CW, Chan WF, Chen JK (2002) Br J Pharmacol 135:1627

    Article  CAS  Google Scholar 

  192. Bradamante S, Barenghi L, Piccinini F, Bertelli AAE, de Jonge R, Beemster P, de Jong JW (2003) Eur J Pharmacol 465:115

    Article  CAS  Google Scholar 

  193. Kaga S, Zhan L, Matsumoto M, Maulik N (2005) J Mol Cell Cardiol 39:813

    Article  CAS  Google Scholar 

  194. Baur JA (2010) Mech Age Dev 131:261

    Article  CAS  Google Scholar 

  195. Hu Y, Wang J, Liu Q (2011) Free Rad Biol Med 51:250

    Article  CAS  Google Scholar 

  196. Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Pelegri C, Vilaplana J, Beas-Zarate C, Pallas M (2010) Biochim Biophys Acta 1799:740

    Article  CAS  Google Scholar 

  197. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Nature 425:191

    Article  CAS  Google Scholar 

  198. Wood JG, Rogina B, Lavu S, Howitz K, Helfand S, Tatar M, Sinclair D (2004) Nature 430:686

    Article  CAS  Google Scholar 

  199. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006) Curr Biol 16:296

    Article  CAS  Google Scholar 

  200. Kaberlain M, McDonagh T, Heltweg B, Hixon J, Westman EA, Cadwell SD, Napper A, Curtis R, Distefano PS, Fields S, Bedalov A, Kennedy BK (2005) J Biol Chem 280:17038

    Article  CAS  Google Scholar 

  201. Pacholec M, Chrunyk BA, Cunningham D, Flynn D, Griffith DA, Griffor M, Loukakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K (2010) J Biol Chem 285:8340

    Article  CAS  Google Scholar 

  202. Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, Hoddinott M, Sutphin GL, Leko V, McElwee JJ, Vazquez-Manrique RP, Orfila AM, Ackerman D, Au C, Vinti G, Riesen M, Howard K, Neri C, Bedalov A, Kaeberlein M, Soti C, Partridge L, Gems D (2011) Nature 477:482

    Article  CAS  Google Scholar 

  203. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C et al (2006) Nature 444:337

    Article  CAS  Google Scholar 

  204. Kennedy DO, Wightman EL, Reay JL, Lietz G, Okello EJ, Wilde A, Haskell CF (2010) Am J Clin Nutr 91:1590

    Article  CAS  Google Scholar 

  205. Kamper AM, Split A, de Craen AJM, van Buchem MA, Westendorp RGJ, Blauw GJ (2004) Exp Gerontol 39:1245

    Article  CAS  Google Scholar 

  206. Lambert JD, Hong J, Hwan Kim D, Mishin VM, Yang CS (2004) J Nutr 134:1948

    CAS  Google Scholar 

  207. Ndiaye M, Kumar R, Ahmad N (2011) Ann N Y Acad Sci 1215:144

    Article  CAS  Google Scholar 

  208. Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K (2011) Ann N Y Acad Sci 1215:161

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. ISVV, Groupe d’Etude des Substances Végétales à Activité Biologique, EA 3675, Université de Bordeaux, 210, Chemin de Leysotte, 33140, Villenave d’Ornon, France

    Pierre Waffo-Téguo, Stéphanie Krisa, Alison D. Pawlus, Tristan Richard, Jean-Pierre Monti & Prof. Jean-Michel Mérillon

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  1. Pierre Waffo-Téguo
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  2. Stéphanie Krisa
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  3. Alison D. Pawlus
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  4. Tristan Richard
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  5. Jean-Pierre Monti
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  6. Prof. Jean-Michel Mérillon
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Correspondence to Jean-Michel Mérillon .

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  1. Botany Department, M.L. Sukhadia University, Durga Nursery Road, Udaipur, 313001, Rajasthan, India

    Kishan Gopal Ramawat

  2. Institute of Vine and Wine Sciences, Biological-Active Plant Substances Study, University of Bordeaux, 210 Chemin de Leysotte CS 50008, Villenave d'Ornon, 33882, France

    Jean-Michel Mérillon

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Waffo-Téguo, P., Krisa, S., Pawlus, A.D., Richard, T., Monti, JP., Mérillon, JM. (2013). Grapevine Stilbenoids: Bioavailability and Neuroprotection. In: Ramawat, K., Mérillon, JM. (eds) Natural Products. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22144-6_74

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