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Management of Acute Kidney Failure

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Pediatric Nephrology

Abstract

No uniform acute kidney injury (AKI) treatment strategies exist currently. Lack of consensus results from the inability to detect AKI early enough to prevent the cascade of cellular events leading to renal tubular cell death, since current diagnosis relies on serum creatinine changes. The recent discovery of early biomarkers of AKI may allow for detection prior to serum creatinine changes and interventional trials to prevent AKI development. Until then, AKI management, summarized in Table 66-1 , remains supportive, aimed at maintaining fluid and electrolyte homeostasis, preventing life-threatening complications, avoiding further kidney injury, providing appropriate nutrition and renal replacement therapy (RRT) in the most severe forms of AKI. The current chapter outlines these management concepts with a focus on RRT – in particular continuous renal replacement therapy (CRRT).

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Author information

Authors and Affiliations

  1. Pediatrics, Division of Nephrology, Montreal Children’s Hospital, McGill University Health Center, Montreal, QC, Canada

    Michael Zappitelli

  2. Stuart Goldstein, Pediatrics, Renal Section, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA

    Stuart L. Goldstein

Authors
  1. Michael Zappitelli
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  2. Stuart L. Goldstein
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Editor information

Editors and Affiliations

  1. Medical College of Wisconsin, Wisconsin, USA

    Ellis Avner (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology) (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology)

  2. Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    William Harmon (Professor of Pediatrics, Director, Pediatric Nephrology) (Professor of Pediatrics, Director, Pediatric Nephrology)

  3. Service de Néphrologie Pédiatrique Centre de référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Hôpital Necker‐Enfants Malades, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    Patrick Niaudet

  4. Department of Pediatrics Wakayama Medical University, Wakayama Medical University Hospital, 641–8510811–1, Kimiidera, Wakayama City, Japan

    Norishige Yoshikawa (Professor and Chair Pediatrician‐in‐Chief) (Professor and Chair Pediatrician‐in‐Chief)

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Zappitelli, M., Goldstein, S.L. (2009). Management of Acute Kidney Failure. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76341-3_66

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  • DOI: https://doi.org/10.1007/978-3-540-76341-3_66

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-76327-7

  • Online ISBN: 978-3-540-76341-3

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