Abstract
In critically ill children weighing <10 kg, it is necessary to use blood as a priming solution for the extracorporeal continuous renal replacement therapy (CRRT) circuit before initiating CRRT to prevent hemodilution and maintain adequate oxygenation. However, blood bank blood usually contains supra-physiological electrolyte concentrations and a non-physiological acid-base balance that may exacerbate the patient’s condition. The objective of this trial was to develop a simple protocol to pre-treat blood bank-derived blood to yield a more physiological blood priming solution. Expired human blood in a recirculating in vitro CRRT circuit was dialyzed prior to the initiation of CRRT using a physiological dialysate solution. Serial blood samples were assessed for electrolyte and pH content. Regimens using maximal blood flow rates (180–200 ml/min) and aggressive dialysate flow rates (33–42 ml/min) were able to correct severely hyperkalemic and acidemic blood within 7.5 min. Initially elevated blood potassium concentrations >20 mEq/l were normalized to below 5 mEq/l within 7.5 min of dialysis in all cases. Blood bank-derived blood can be “conditioned” quickly to physiological pH and electrolyte concentrations using these simple pre-dialysis regimens. Unlike some blood preparation regimens that have been published, the technique used in this trial requires no special equipment or added medications that are not already used in CRRT.
Similar content being viewed by others
References
Brophy PD, Mottes TA, Kudelka TL, McBryde KD, Gardner JJ, Maxvold NJ, Bunchman TE (2001) AN-69 membrane reactions are pH-dependent and preventable. Am J Kidney Dis 38:173–178
Nagashima M, Imai Y, Seo K, Terada M, Aoki M, Shinoka T, Koide M (2000) Effect of hemofiltrated whole blood pump priming on hemodynamics and respiratory function after the arterial switch operation in neonates. Ann Thorac Surg 70:1901–1906
Journois D, Israel-Biet D, Pouard P, Rolland B, Silvester W, Vouhe P, Safran D (1996) High-volume, zero-balanced hemofiltration to reduce delayed inflammatory response to cardiopulmonary bypass in children. Anesthesiology 85:965–976
Evans WE, Schentag JJ, Jusko WJ (1992) Applied pharmacokinetics, principles of therapeutic drug monitoring, 3rd edn. Applied Therapeutics, Vancouver, Wash, pp 2–29
Chadha V, Garg U, Warady BA, Alon US (2002) Citrate clearance in children receiving continuous venovenous renal replacement therapy. Pediatr Nephrol 17:819–824
Millar AB, Armstrong L, Linden J van der, Moat N, Ekroth R, Westwick J, Scallan M, Lincoln C (1993) Cytokine production and hemofiltration in children undergoing cardiopulmonary bypass. Ann Thorac Surg 56:1499–1502
Plotz FB, Oeveren W van, Bartlett RH, Wildevuur CR (1993) Blood activation during neonatal extracorporeal life support. Thorac Cardiovasc Surg 105:823–832
Acknowledgements
The authors acknowledge the contributions of Dr. Robertson D. Davenport for providing the blood products for this trial and of B. Braun Medical Incorporated for providing materiel support.
Author information
Authors and Affiliations
Corresponding author
Additional information
This manuscript was presented in poster form on 3 March 2003 at the 8th International Conference on Continuous Renal Replacement Therapies, San Diego, California, USA
Rights and permissions
About this article
Cite this article
Pasko, D.A., Mottes, T.A. & Mueller, B.A. Pre dialysis of blood prime in continuous hemodialysis normalizes pH and electrolytes. Pediatr Nephrol 18, 1177–1183 (2003). https://doi.org/10.1007/s00467-003-1258-2
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-003-1258-2