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Hypertension in the Developing World

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Pediatric Hypertension

Abstract

Hypertension is a major global chronic noncommunicable disease (NCD). Despite continued efforts to establish public policies to ensure surveillance and monitoring, the absolute numbers of patients affected by hypertension in low- and middle-income countries are likely to grow, as economic improvement favors longer life expectancy. Increasing longevity provides longer periods of exposure to the risk factors of cardiovascular disease (CVD), resulting in a greater probability of clinical manifestation of CVD events, especially because of the lack of awareness and insufficient treatment of the affected individuals.

The survivors of an economic transition period are more likely to present the phenotype of lower birth weight coupled with either stunting or a higher body mass index in childhood or adulthood, which appears to be associated with the highest risks of morbid cardiovascular, renal, and metabolic outcomes into adulthood.

The combination of population-wide and individual interventions may save millions of lives and considerably reduce human suffering from NCDs.

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References

  • Addo J, Smeeth L, Leon DA (2007) Hypertension in sub-Saharan Africa: a systematic review. Hypertension 50:1012–1018

    Article  CAS  PubMed  Google Scholar 

  • Armitage JA, Khan IY, Taylor PD, Nathanielsz PW, Poston L (2004) Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol 561:355–377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bagby SP (2007) Maternal nutrition, low nephron number, and hypertension in later life: pathways of nutritional programming. J Nutr 137:1066–1072

    Article  CAS  PubMed  Google Scholar 

  • Barker DJ (2004) Developmental origins of adult health and disease. J Epidemiol Community Health 58:114–115

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barker DJP (2012) Sir Richard doll lecture developmental origins of chronic disease. Public Health 126:185–189

    Article  CAS  PubMed  Google Scholar 

  • Barker DJ, Osmond C (1986) Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1:1077–1081

    Article  CAS  PubMed  Google Scholar 

  • Barker DJ, Osmond C, Golding J, Kuh D, Wadsworth ME (1989a) Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ 298:564–567

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barker DJ, Osmond C, Law CM (1989b) The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health 43:237–240

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barker DJ, Osmond C, Winter PD, Margetts BM, Simmonds SJ (1989c) Weight in infancy and death from ischaemic heart disease. Lancet 2:577–580

    Article  CAS  PubMed  Google Scholar 

  • Barker DJ, Bull AR, Osmond C, Simmonds SJ (1990) Fetal and placental size and risk of hypertension in adult life. BMJ 301:259–262

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS (1993a) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidemia (syndrome X): relation to reduced fetal growth. Diabetologia 36:62–67

    Article  CAS  PubMed  Google Scholar 

  • Barker DJP, Martyn CN, Osmond C, Haleb CN, Fall CHD (1993b) Growth in utero and serum cholesterol concentrations in adult life. BMJ 307:1524–1527

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barker DJ, Eriksson JG, Forsen T, Osmond C (2002) Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 31:1235–1239

    Article  CAS  PubMed  Google Scholar 

  • Barker DJ, Osmond C, Forsén TJ, Kajantie E, Eriksson JG (2005) Trajectories of growth among children who have coronary events as adults. N Engl J Med 353:1802–1809

    Article  CAS  PubMed  Google Scholar 

  • Bateson P, Barker D, Clutton-Brock T, Deb D, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Mirazón Lahr M, Macnamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE (2004) Developmental plasticity and human health. Nature 430(430):419–421

    Article  CAS  PubMed  Google Scholar 

  • Bergvall N, Iliadou A, Johansson S, de Faire U, Kramer MS, Pawitan Y, Pedersen NL, Lichtenstein P, Cnattingius S (2007) Genetic and shared environmental factors do not confound the association between birth weight and hypertension: a study among Swedish twins. Circulation 115:2931–2938

    Article  PubMed  Google Scholar 

  • Blanchette E, Flynn JT (2019) Implications of the 2017 AAP clinical practice guidelines for Management of Hypertension in children and adolescents: a review. Curr Hypertens Rep 21(5):35. https://doi.org/10.1007/s11906-019-0943-x. PMID: 30953215; PMCID: PMC6705594

    Article  PubMed  PubMed Central  Google Scholar 

  • Blencowe H, Krasevec J, de Onis M, Black RE, An X, Stevens GA et al (2019) National, regional, and worldwide estimates of low birthweight in 2015, with trends from 2000: a systematic analysis. Lancet Glob Health 7(7):e849–e860. ISSN 2214-109X

    Article  PubMed  PubMed Central  Google Scholar 

  • Boyko EJ (2000) Proportion of type 2 diabetes cases resulting from impaired fetal growth. Diabetes Care 23:1260–1264

    Article  CAS  PubMed  Google Scholar 

  • Brook JS, Whiteman M, Brook DW (1999) Transmission of risk factors across three generations. Psychol Rep 85:227–241

    Article  CAS  PubMed  Google Scholar 

  • Brouwers S, Sudano I, Kokubo Y, Sulaica EM (2021) Arterial hypertension. The Lancet 398(10296):249–261. https://doi.org/10.1016/S0140-6736(21)00221-X. ISSN 0140-6736

    Article  CAS  Google Scholar 

  • Campese VM, Parise M, Karubian F, Bigazzi R (1991) Abnormal renal hemodynamics in black salt-sensitive patients with hypertension. Hypertension 18:805–812

    Article  CAS  PubMed  Google Scholar 

  • Celsi G, Kistner A, Aizman R, Eklöf AC, Ceccatelli S, de Santiago A, Jacobson SH (1998) Prenatal dexamethasone causes oligonephronia, sodium retention, and higher blood pressure in the offspring. Pediatr Res 44:317–322

    Article  CAS  PubMed  Google Scholar 

  • Chiolero A, Cachat F, Burnier M, Paccaud F, Bovet P (2007) Prevalence of hypertension in schoolchildren based on repeated measurements and association with overweight. J Hypertens 25(11):2209–2217. https://doi.org/10.1097/HJH.0b013e3282ef48b2

    Article  CAS  PubMed  Google Scholar 

  • Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents, Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, de Ferranti SD, Dionne JM, Falkner B, Flinn SK, Gidding SS, Goodwin C, Leu MG, Powers ME, Rea C, Samuels J, Simasek M, Thaker VV, Urbina EM (2017) Subcommittee on screening and management of high blood pressure in children. Pediatrics 140(3):e20171904. https://doi.org/10.1542/peds.2017-1904

    Article  Google Scholar 

  • Curhan GC, Willett WC, Rimm EB, Spiegelman D, Ascherio AL, Stampfer MJ (1996) Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 94:3246–3250

    Article  CAS  PubMed  Google Scholar 

  • Eriksson JG, Osmond C, Barker DJ (2003) Pathways of infant and childhood growth that lead to type 2 diabetes. Diabetes Care 26:3006–3010

    Article  PubMed  Google Scholar 

  • Ezzati M, Obermeyer Z, Tzoulaki I, Mayosi BM, Elliott P, Leon DA (2015) The contributions of risk factors and medical care to cardiovascular mortality trends. Nat Rev Cardiol 12(9):508–530

    Article  PubMed  PubMed Central  Google Scholar 

  • GBD (2019) Diseases and Injuries Collaborators Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 396:1204–1222. https://doi.org/10.1016/S0140-6736(20)30925-9

    Article  Google Scholar 

  • Gilbert T, Lelievre-Pegorier M, Merlet-Benichou C (1991) Long-term effects of mild oligonephronia induced in utero by gentamicin in the rat. Pediatr Res 30:450–456

    Article  CAS  PubMed  Google Scholar 

  • Gluckman PD, Hanson MA (2004) Living with the past: evolution, development and patterns of disease. Science 305:1733–1736

    Article  CAS  PubMed  Google Scholar 

  • Gluckman PD, Hanson MA, Beedle AS (2007) Early life events and their consequences for later disease; a life history and evolutionary perspective. Am J Hum Biol 19:1–19

    Article  PubMed  Google Scholar 

  • Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA (2007) Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res 61((5), Part 2 Supplement):5R–10R

    Article  PubMed  Google Scholar 

  • Hales CN, Barker DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35:595–601

    Article  CAS  PubMed  Google Scholar 

  • Hales CN, Barker DJP (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5–20

    Article  CAS  PubMed  Google Scholar 

  • Health in 2015: from MDGs to SDGs. Non-communicable diseases. https://www.who.int/data/gho/publications/mdgs-sdgs. Accessed 30 Sept 2021

  • Heard E, Martienssen RA (2014) Transgenerational epigenetic inheritance: myths and mechanisms. Cell 157:95–109

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hinchliffe SA, Lynch MR, Sargent PH, Howard CV, Van Velzen D (1992) The effect of intrauterine growth retardation on the development of renal nephrons. Br J Obstet Gynaecol 99:296–301

    Article  CAS  PubMed  Google Scholar 

  • Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J et al (2016) Genome-wide associations for birth weight and correlations with adult disease. Nature 538:248–252

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoy WE, Hughson MD, Singh GR, Douglas-Denton R, Bertram JF (2006) Reduced nephron number and glomerulomegaly in Australian aborigines. A group at high risk for renal disease and hypertension. Kidney Int 70:104–110

    Article  CAS  PubMed  Google Scholar 

  • https://www.who.int/cardiovascular_diseases/guidelines/PocketGL.ENGLISH.AFR-D-E.rev1.pdf. Accessed 30 Sept 2021

  • https://www.who.int/maternal_child_adolescent/documents/MPSProgressReport09-FINAL.pdf. Accessed 30 Sept 2021

  • https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed 30 Sept 2021

  • https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Accessed 30 Sept 2021

  • https://www.who.int/nutgrowthdb/jme_brochure2016.pdf. Accessed 30 Sept 2021

  • https://www.who.int/publications/i/item/WHO-NMH-NHD-14.3

  • https://www.who.int/reproductivehealth/publications/maternal_perinatal_health/RHR_03_11/en/. Accessed 30 Sept 2021

  • Jackson AA (2000) All that glitters. British Nutrition Foundation Annual Lecture. Nutr Bull 25:11–24

    Article  Google Scholar 

  • Juhola J, Magnussen CG, Berenson GS et al (2013) Combined effects of child and adult elevated blood pressure on subclinical atherosclerosis: the international childhood cardiovascular cohort consortium. Circulation 128(3):217–224. https://doi.org/10.1161/CIRCULATIONAHA.113.001614

    Article  PubMed  Google Scholar 

  • Juonala M, Viikari JS, Raitakari OT (2013) Main findings from the prospective cardiovascular risk in young Finns study. Curr Opin Lipidol 24(1):57–64. https://doi.org/10.1097/MOL.0b013e32835a7ed4)

    Article  CAS  PubMed  Google Scholar 

  • Kajantie E, Osmond C, Barker DJ, Forsén T, Phillips DI, Eriksson JG (2005) Size at birth as a predictor of mortality in adulthood: a follow-up of 350,000 person-years. Int J Epidemiol 34:655–663

    Article  PubMed  Google Scholar 

  • Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J (2005) Global burden of hypertension: analysis of worldwide data. Lancet 365:217–223

    Article  PubMed  Google Scholar 

  • Keijzer-Veen MG, Schrevel M, Finken MJ, Dekker FW, Nauta J, Hille ET, Frölich M, van der Heijden BJ, Dutch POPS-19 Collaborative Study Group (2005) Microalbuminuria and lower glomerular filtration rate at young adult age in subjects born very premature and after intrauterine growth retardation. J Am Soc Nephrol 16:2762–2768

    Article  CAS  PubMed  Google Scholar 

  • Kelishadi R, Farajian S (2014) The protective effects of breastfeeding on chronic non-communicable diseases in adulthood: a review of evidence. Adv Biomed Res 3:3

    Article  PubMed  PubMed Central  Google Scholar 

  • Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348:101–108

    Article  PubMed  Google Scholar 

  • Kelly RK, Thomson R, Smith KJ, Dwyer T, Venn A, Magnussen CG (2015) Factors affecting tracking of blood pressure from childhood to adulthood: the childhood determinants of adult health study. J Pediatr 167(6):1422–8.e2. https://doi.org/10.1016/j.jpeds.2015.07.055

    Article  PubMed  Google Scholar 

  • Koskinen JS, Kytö V, Juonala M, Viikari JSA, Nevalainen J, Kähönen M, Lehtimäki T, Hutri-Kähönen N, Laitinen T, Tossavainen P, Jokinen E, Magnussen CG, Raitakari OT (2020) Childhood risk factors and carotid atherosclerotic plaque in adulthood: the cardiovascular risk in young Finns study. Atherosclerosis 293:18–25. https://doi.org/10.1016/j.atherosclerosis.2019.11.029)

    Article  CAS  PubMed  Google Scholar 

  • Lackland DT, Bendall HE, Osmond C, Egan BM, Barker DJ (2000) Low birth weights contribute to high rates of early-onset chronic renal failure in the Southeastern United States. Arch Intern Med 160:1472–1476

    Article  CAS  PubMed  Google Scholar 

  • Law CM, de Swiet M, Osmond C, Fayers PM, Barker DJ, Cruddas AM, Fall CH (1993) Initiation of hypertension in utero and its amplification throughout life. BMJ 306:24–27

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lelièvre-Pégorier M, Vilar J, Ferrier ML, Moreau E, Freund N, Gilbert T, Merlet-Bénichou C (1998) Mild vitamin a deficiency leads to inborn nephron deficit in the rat. Kidney Int 54:1455–1462

    Article  PubMed  Google Scholar 

  • Lucas A (1991) Programming by early nutrition in man. Ciba Found Symp 156:38–50

    CAS  PubMed  Google Scholar 

  • Lumey LH, Stein AD (1997) Offspring birth weights after maternal intrauterine undernutrition: a comparison within sibships. Am J Epidemiol 146:810–819

    Article  CAS  PubMed  Google Scholar 

  • Mcmillen C, Robinson JS (2005) Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85:571–633

    Article  CAS  PubMed  Google Scholar 

  • McNiece KL, Poffenbarger TS, Turner JL, Franco KD, Sorof JM, Portman RJ (2007) Prevalence of hypertension and pre-hypertension among adolescents. J Pediatr 150(6):640–644, 644.e1. https://doi.org/10.1016/j.jpeds.2007.01.052)

    Article  PubMed  Google Scholar 

  • Mittal BV, Singh AK (2010) Hypertension in the developing world: challenges and opportunities. Am J Kidney Dis 55:590–598

    Article  PubMed  Google Scholar 

  • NCD Risk Factor Collaboration (NCD-RisC) (2021) Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet 398(10304):957–980

    Article  Google Scholar 

  • Neel JV (1962) Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet 14:353–362

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ong M-L, Lin X, Holbrook JD (2015) Measuring epigenetics as the mediator of gene/environment interactions in DOHaD. J Dev Orig Health Dis 6:10–16

    Article  CAS  PubMed  Google Scholar 

  • Painter RC, Roseboom TJ, Bleker OP (2005) Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol 20:345–352

    Article  CAS  PubMed  Google Scholar 

  • Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH (2003) Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol 285:R962–R970

    Article  CAS  PubMed  Google Scholar 

  • Razak F, Anand SS, Shannon H, Vuksan V, Davis B, Jacobs R, Teo KK, McQueen M, Yusuf S (2007) Defining obesity cut points in a multiethnic population. Circulation 115:2111–2118

    Article  PubMed  Google Scholar 

  • Singhal A, Cole TJ, Lucas A (2001) Early nutrition in preterm infants and later blood pressure: two cohorts after randomized trials. Lancet 357:413–419

    Article  CAS  PubMed  Google Scholar 

  • Singhal A, Fewtrell M, Cole TJ, Lucas A (2003) Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. Lancet 361:1089–1097

    Article  CAS  PubMed  Google Scholar 

  • Song P, Zhang Y, Yu J, Zha M, Zhu Y, Rahimi K, Rudan I (2019) Global prevalence of hypertension in children: a systematic review and meta-analysis. JAMA Pediatr 173(12):1154–1163. https://doi.org/10.1001/jamapediatrics.2019.3310

    Article  PubMed  PubMed Central  Google Scholar 

  • STEPS. https://www.who.int/teams/noncommunicable-diseases/surveillance/systems-tools/steps. Accessed 30 Sept 2021

  • Thoman EB, Levine S (1970) Hormonal and behavioral changes in the rat mother as a function of early experience treatments of the offspring. Physiol Behav 5:1417–1421

    Article  CAS  PubMed  Google Scholar 

  • Thrift AG, Srikanth V, Fitzgerald SM, Kalyanram K, Kartik K, Hoppe CC, Walker KZ, Evans RG (2010) Potential roles of high salt intake and maternal malnutrition in the development of hypertension in disadvantaged populations. Clin Exp Pharmacol Physiol 37:e78–e90

    Article  CAS  PubMed  Google Scholar 

  • Tiago AD, Samani NJ, Candy GP, Brooksbank R, Libhaber EN, Sareli P, Woodiwiss AJ, Norton GR (2002) Angiotensinogen gene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension. Circulation 106:1483–1487

    Article  CAS  PubMed  Google Scholar 

  • Transforming our world: the 2030 agenda for sustainable development. https://sdgs.un.org/2030agenda. Accessed 30 Sept 2021

  • Uiterwaal CS, Anthony S, Launer LJ, Witteman JC, Trouwborst AM, Hofman A, Grobbee DE (1997) Birth weight, growth, and blood pressure: an annual follow-up study of children aged 5 through 21 years. Hypertension 30(2 Pt 1):267–271

    Article  CAS  PubMed  Google Scholar 

  • UNICEF & WHO (2019) UNICEF-WHO low birthweight estimates: levels and trends 2000–2015. World Health Organization. https://apps.who.int/iris/handle/10665/324783

  • UNICEF/WHO (2018) Levels and trends in childhood malnutrition/World Bank Group Joint Child Malnutrition Estimates Key findings of the 2018 edition. https://www.who.int/nutgrowthdb/2018-jme-brochure.pdf

  • UNICEF-WHO low birthweight estimates: levels and trends 2000–2015. WHO-NMH-NHD 19.21.-eng pdf. Accessed 30 Sept 2021

    Google Scholar 

  • Unwin N, Harland J, White M, Bhopal R, Winocour P, Stephenson P, Watson W, Turner C, Alberti KG (1997) Body mass index, waist circumference, waist-hip ratio, and glucose intolerance in Chinese and Europid adults in Newcastle, UK. J Epidemiol Community Health 51:160–166

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vehaskari VM, Aviles DH, Manning J (2001) Prenatal programming of adult hypertension in the rat. Kidney Int 59:238–245

    Article  CAS  PubMed  Google Scholar 

  • von Bonsdorff ME, von Bonsdorff MB, Martikainen J, Salonen M, Kajantie E, Kautiainen H, Eriksson JG (2016) Body size at birth and coronary heart disease-related hospital care in adult men – findings from the Helsinki Birth Cohort Study. Ann Med 23:1–16

    Google Scholar 

  • Waddington CH (1957) The strategy of the genes: a discussion of some aspects of theoretical biology. Macmillan, New York

    Google Scholar 

  • Wang Z, Wu Y, Zhao L, Li Y, Yang J, Zhou B, Cooperative Research Group of the Study on Trends of Cardiovascular Diseases in China and Preventive Strategy for the 21st Century (2004) Trends in prevalence, awareness, treatment and control of hypertension in the middle-aged population of China, 1992–1998. Hypertens Res 27:703–709

    Article  PubMed  Google Scholar 

  • West-Eberhard MJ (2003) Developmental plasticity and evolution. Oxford University Press, New York

    Book  Google Scholar 

  • Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C et al (2018) ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and Management of High Blood Pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Hypertension 71(6):1269–1324. https://doi.org/10.1161/HYP.0000000000000066

    Article  CAS  PubMed  Google Scholar 

  • Whincup P, Cook D, Papacosta O, Walker M (1995) Birth weight and blood pressure: cross sectional and longitudinal relations in childhood. BMJ 311:773–776

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • WHO-CHOICE. https://www.who.int/news-room/q-a-detail/who-choice-frequently-asked-questions. Accessed 30 Sept 2021

  • Wing MR, Devaney JM, Joffe MM, Xie D, Feldman HI, Dominic EA et al (2014) Chronic renal insufficiency cohort (CRIC) study. DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study. Nephrol Dial Transplant 29:864–872

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Woods LL, Ingelfinger JR, Nyengaard JR, Rasch R (2001) Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats. Pediatr Res 49:460–467

    Article  CAS  PubMed  Google Scholar 

  • World Health Organization (2009) Global health risks: mortality and burden of disease attributable to selected major risks. World Health Organization, Geneva

    Google Scholar 

  • World Health Organization (2017) Tackling NCDs: ‘best buys’ and other recommended interventions for the prevention and control of noncommunicable diseases. World Health Organization. https://apps.who.int/iris/handle/10665/259232. Accessed 30 Sept 2021

  • Yach D (2004) The global burden of chronic disease: overcoming impediments to prevention and control. JAMA 291:2616–2622

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Pediatric Nephrology, University of Sao Paulo Medical School, São Paulo, Brazil

    Vera H. Koch

  2. Department of Pediatrics, Pediatric Nephrology Unit, Instituto da Criança Hospital das Clinicas, University of São Paulo Medical School, Sao Paulo, Brazil

    Vera H. Koch

  3. Medical Residency, University of Sao Paulo Medical School, Sao Paulo, Brazil

    Vera H. Koch

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  1. Vera H. Koch
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Editors and Affiliations

  1. Division of Nephrology, Seattle Children's Hospital, Seattle, WA, USA

    Joseph T. Flynn

  2. Massachusetts General Hospital, Boston, MA, USA

    Julie R. Ingelfinger

  3. Johns Hopkins University, Baltimore, MD, USA

    Tammy Brady

Section Editor information

  1. University of Washington School of Medicine, Seattle, WA, USA

    Joseph T. Flynn MD, MS

  2. Divison of Nephrology, Seattle Children’s Hospital, Seattle, WA, USA

    Joseph T. Flynn MD, MS

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Koch, V.H. (2022). Hypertension in the Developing World. In: Flynn, J.T., Ingelfinger, J.R., Brady, T. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31420-4_31-2

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    Hypertension in the Developing World
    Published:
    12 April 2022

    DOI: https://doi.org/10.1007/978-3-319-31420-4_31-2

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    Hypertension in the Developing World
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    04 January 2017

    DOI: https://doi.org/10.1007/978-3-319-31420-4_31-1

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