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Amentoflavone: Structure, Resources, Biosynthetic Pathway and Bioactivity and Pharmacology

Handbook of Dietary Flavonoids

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Abstract

Amentoflavone is a naturally occurring biflavonoid first identified in Selaginella species in 1971. Even before amentoflavone was isolated from Selaginella, extracts of this plant were used extensively in traditional medicine for the treatment of various health problems. Today, it is known that amentoflavone is a constituent of numerous plants, including species from Calophyllaceae, Cupressaceae, Euphorbiaceae, Selaginellaceae, etc. The beneficial effects of amentoflavone are high and have strong anticancer, neuroprotective, antiviral, and anti-inflammatory effects. However, its beneficial effects on the gastrointestinal tract and cardiovascular system are also worth further investigation. Currently, the use of amentoflavone as a drug has been investigated in vivo through oral delivery systems, but these have not proven to be very effective, achieving only low bioavailability of amentoflavone in plasma and other tissues. Trials using an oral delivery system with micelles have proven to be more effective, but further research is needed to optimize the use of amentoflavone for higher bioavailability. Considering its beneficial effects, in vivo studies have demonstrated the high efficacy of amentoflavone as an anti-inflammatory agent for various conditions such as ulcers, psoriasis, arthritis, and other inflammatory diseases, as an antiviral agent, including SARS-Cov2, as a neuroprotective agent to improve cognitive function and eliminate toxic oligomers in tests associated with the onset of Alzheimer’s and Parkinson’s diseases, and as a potent anticarcinogenic agent with effects not only on reducing tumor growth but also on its metastatic power.

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Acknowledgment

This work has been supported by Croatian Science Foundation project “Biflavonoids role in plants: Ginkgo biloba L. as a model system” under the project no. UIP-2019-04-1018.

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  1. Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    Erna Karalija

  2. Department of Food Technology, University Center Koprivnica, Koprivnica, Croatia

    Dunja Šamec

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    Jianbo Xiao

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Karalija, E., Šamec, D. (2023). Amentoflavone: Structure, Resources, Biosynthetic Pathway and Bioactivity and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_60-1

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  1. Latest

    Amentoflavone: Structure, Resources, Bioactivity and Pharmacology
    Published:
    27 September 2023

    DOI: https://doi.org/10.1007/978-3-030-94753-8_60-2

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    Amentoflavone: Structure, Resources, Biosynthetic Pathway and Bioactivity and Pharmacology
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    03 August 2023

    DOI: https://doi.org/10.1007/978-3-030-94753-8_60-1

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