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Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation

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Summary

The antiperoxidative effects of 35 phenolic compounds, most of them belonging to the flavonoid class, were investigated using CCl4-induced peroxidation of rat liver microsomes. This system was rather insensitive to gallic acid, methyl gallate and ellagic acid. Nevertheless it was inhibited by flavonoids and structure/activity relationships were established. The most potent compounds were gardenin D, luteolin, apigenin (flavones), datiscetin, morin, galangin (flavonols), eriodictyol (flavanone), amentoflavone (biflavone) and the reference compound, (+)-catechin. The natural polymethoxyflavone gardenin D has shown a potency comparable to that of (+)-catechin and higher than that of silybin. Thus, it may be considered as a new type of natural antioxidant with potential therapeutical applications.

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Authors and Affiliations

  1. Departamento de Farmacologia y Farmacotecnia, Facultad de Farmacia, Avda. Blasco Ibáñez 13, E-46010, Valencia, Spain

    M. R. Cholbi, M. Paya & M. J. Alcaraz

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  1. M. R. Cholbi
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  2. M. Paya
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  3. M. J. Alcaraz
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Cholbi, M.R., Paya, M. & Alcaraz, M.J. Inhibitory effects of phenolic compounds on CCl4-induced microsomal lipid peroxidation. Experientia 47, 195–199 (1991). https://doi.org/10.1007/BF01945426

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  • DOI: https://doi.org/10.1007/BF01945426

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