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Phloretin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

  • Living reference work entry
  • First Online:
Handbook of Dietary Flavonoids

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Abstract

Phloretin is a dihydrochalcone found in various plant sources such as apples, strawberries, kumquat, pears, honeybush, and sweet tea. Numerous studies have revealed the pleiotropic pharmacology of phloretin, being endowed with anticancer, anti-inflammatory, antidiabetic, neuroprotective, and antimicrobial effects. These activities have been demonstrated in both in vitro and in vivo experimental setups. Only few clinical studies have highlighted its promising potential in alleviating skin-related disorders. Still, further research is needed to assess whether the preclinical data translate into similar findings in clinical settings. Phloretin is marketed globally as a cosmetic ingredient, with a good safety profile. Chemical features of phloretin, biosynthesis, pharmacokinetics, molecular mechanisms of activity, pharmacology in animals, toxicology, clinical trials, patents, and marketed products are summarized in this chapter.

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Authors and Affiliations

  1. Department of Pharmacognosy-Phytotherapy, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania

    Adriana Trifan

  2. Biothermodynamics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany

    Simon Vlad Luca

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  1. Adriana Trifan
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  2. Simon Vlad Luca
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Correspondence to Adriana Trifan .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Trifan, A., Luca, S.V. (2023). Phloretin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_26-1

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  • DOI: https://doi.org/10.1007/978-3-030-94753-8_26-1

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