Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications

Schoen, Frederick J.; Fioretta, Emanuela S.; Mallone, Anna; Smits, Anthal I. P. M.; Klouda, Leda; Bouten, Carlijn V. C.

doi:10.1007/978-3-030-05336-9_15

Frederick J. Schoen⁷,
Emanuela S. Fioretta⁸,
Anna Mallone⁸,
Anthal I. P. M. Smits^10,11,
Leda Klouda⁹ &
…
Carlijn V. C. Bouten⁹

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

680 Accesses
2 Citations

In the initially published version the authors Emanuela S. Fioretta and Anthal I. P. M. Smits were missing, they have now been included.

The correction to the chapter can be found at https://doi.org/10.1007/978-3-030-05336-9_24.

Abstract

Clinical translation of vascular tissue engineering is hampered by inconsistencies in graft outcomes. In this chapter, we argue that variation in graft outcomes is largely due to our lack of fully understanding vascular regeneration and remodeling in response to specific graft properties. In addition, results obtained from animal studies are difficult to translate into patients. This is mainly due to interspecies variation in vascular regeneration, as well as inter-patient variation in factors influencing regeneration, such as gender, age, clinical condition, and use of medication. Following a review of vascular structure as a blueprint for tissue-engineered grafts and vascular pathologies necessitating such grafts, we describe potential mechanisms of host-graft interaction that explain outcome variability. Next, we propose research strategies to carefully move from understanding (variability in) vascular regeneration to robust and personalized graft design and outcomes.

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Change history

07 October 2020
Owing to an unfortunate oversight during the production process, chapter “Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications” was initially published with incomplete authorship information. This has now been corrected.

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Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
Frederick J. Schoen
Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland
Emanuela S. Fioretta & Anna Mallone
Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands
Leda Klouda & Carlijn V. C. Bouten
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
Anthal I. P. M. Smits
Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands
Anthal I. P. M. Smits

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Frederick J. Schoen
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Emanuela S. Fioretta
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Anna Mallone
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Anthal I. P. M. Smits
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Leda Klouda
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Carlijn V. C. Bouten
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Correspondence to Carlijn V. C. Bouten .

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Emeritus, Cardiovascular Surgery and Research, University Hospital and University of Geneva, Geneva, Switzerland
Beat H. Walpoth
Center for Biomedical Research, Medical University Vienna, Vienna, Austria
Helga Bergmeister
Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA
Gary L. Bowlin
Key Laboratory of Bioactive Materials of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China
Deling Kong
Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Joris I. Rotmans
Chris Barnard Division of Cardiothoracic Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, Saudi Arabia
Peter Zilla

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Schoen, F.J., Fioretta, E.S., Mallone, A., Smits, A.I.P.M., Klouda, L., Bouten, C.V.C. (2020). Vascular Tissue Engineering: Pathological Considerations, Mechanisms, and Translational Implications. In: Walpoth, B.H., Bergmeister, H., Bowlin, G.L., Kong, D., Rotmans, J.I., Zilla, P. (eds) Tissue-Engineered Vascular Grafts. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-05336-9_15

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DOI: https://doi.org/10.1007/978-3-030-05336-9_15
Published: 21 August 2020
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