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Vascular Calcification in Diabetes: Mechanisms and Implications

  • Macrovascular Complications in Diabetes (PD Reaven, Section Editor)
  • Published:
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Abstract

Cardiovascular disease (CVD) remains the leading cause of death among adults with diabetes, and CVD prevention remains a major challenge. Coronary artery calcium (CAC) score measured by electron beam tomography (EBT) or multi-slice detector computed tomography correlates closely with plaque burden and coronary angiography, and predicts coronary events independently of other risk factors. Further, progression of CAC over several years has been shown to predict increased mortality. Coronary calcification is an active process strongly associated with atherosclerotic plaque evolution and is an accepted surrogate endpoint in studies of patients with diabetes older than 30. In this review, recent findings regarding the mechanisms and implications of vascular calcification in diabetes will be discussed.

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Conflict of Interest

Janet K. Snell-Bergeon declares that she has no conflict of interest.

Matthew J Budoff declares that he has no conflict of interest.

John E. Hokanson declares that he has no conflict of interest.

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Authors and Affiliations

  1. Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, 1775 Aurora Ct, Mail Stop A140, Aurora, CO, 80045, USA

    Janet K. Snell-Bergeon

  2. Los Angeles Biomedical Research Institute, 1124 W Carson Street, Torrance, CA, 90502, USA

    Matthew J. Budoff

  3. Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA

    John E. Hokanson

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  1. Janet K. Snell-Bergeon
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  2. Matthew J. Budoff
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  3. John E. Hokanson
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Correspondence to Janet K. Snell-Bergeon.

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Snell-Bergeon, J.K., Budoff, M.J. & Hokanson, J.E. Vascular Calcification in Diabetes: Mechanisms and Implications. Curr Diab Rep 13, 391–402 (2013). https://doi.org/10.1007/s11892-013-0379-7

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