Abstract:
Humans have long searched for the origins of distinctive traits including character and emotion. Central to these investigations have been studies of the human brain. Following the first clinical characterization of schizophrenia by Kraepelin (1887) as a unique psychiatric illness and the realization that mental illness resides in select areas of the brain (Crichton-Browne, 1879), the use of postmortem brain to study the pathophysiology of psychiatric illness has significantly advanced our understanding of these disorders.
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Abbreviations
- α-Bgtx:
-
α-bungarotoxin
- 5HT:
-
serotonin
- 7TM:
-
seven-transmembrane
- AC:
-
adelylate cyclase
- ACC:
-
anterior cingulate cortex
- AChR:
-
Acetylcholine receptor
- ADRA1A:
-
α1A-adrenergic receptor
- AMPA:
-
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
- αAR:
-
α-adrenoreceptor
- βAR:
-
β-adrenoreceptor
- BZ:
-
benzodiazepines
- cAMP:
-
cyclic adenosine monophosphate
- CB:
-
cannabinoid receptor
- CNS:
-
central nervous system
- DA:
-
dopamine
- DAG:
-
diacylglycerol
- DLPFC:
-
dorsolateral prefrontal cortex
- DSE/DSI:
-
depolarization-induced suppression of activation/inhibition
- EAAT:
-
excitatory amino acid transporter
- ER:
-
endoplasmic reticulum
- GABA:
-
γ-aminobutyric acid
- GPCR:
-
G-protein coupled receptor
- IAR:
-
immunoautoradiography
- iGluR:
-
ionotropic glutamate receptor
- IP3:
-
inositol 1,4,5 triphosphate
- LSD:
-
D-lysergic acid diethylamide
- mAChR:
-
muscarinic acetylcholine receptor
- mgluR:
-
metabotropic glutamate receptor
- NA:
-
neurokinin A
- nAChR:
-
nicotinic acetylcholine receptor
- NB:
-
neurokinin B
- NF-L:
-
neuro-filament light chain
- nM:
-
nanomolar
- NMDA:
-
N-methyl-D-aspartate
- NSF:
-
N-ethylmaeimide-sensitive fusion protein
- OC:
-
occipital cortex
- PCC:
-
posterior cingulate cortex
- PDZ:
-
postsynaptic density protein, Drosophila disc large tumor suppressor, Zonula occludens 1 protein
- PFC:
-
prefrontal cortex
- PI:
-
phosphatidyl-inositol
- PKC:
-
protein kinase C
- PLC:
-
phospholipase C
- PSD:
-
postsynaptic density
- RGS:
-
Regulators of G protein signaling
- SN:
-
substantia nigra
- SP:
-
substance P
- Stg:
-
stargazin
- TG:
-
temporal gyrus
- VTA:
-
ventral tegmental area
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Acknowledgements
The authors are supported by MH53327 and MH70895 from NIMH (JMW), MH74016 from NIMH (REM), NARSAD Young Investigator Award (LVK), and the Health Services Foundation of the University of Alabama (RMC).
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Kristiansen, L.V., Cowell, R.M., Biscaia, M., McCullumsmith, R.E., Meador-Woodruff, J.H. (2009). Alterations of Neurotransmitter Receptors in Schizophrenia: Evidence from Postmortem Studies. In: Lajtha, A., Javitt, D., Kantrowitz, J. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30410-6_14
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