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(3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients

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Summary

[3H]MK-801 binding was used as a marker for the NMDA receptor-ion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.

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Author notes

  1. J. Kornhuber

    Present address: Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

Authors and Affiliations

  1. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    F. Mack-Burkhardt, P. Riederer & H. Beckmann

  2. Landeskrankenhaus, Amstetten/Mauer, Austria

    G. F. Hebenstreit

  3. Department of Pathology, University of Nottingham, Nottingham, UK

    G. P. Reynolds

  4. Institute of Psychiatry, University of London, London, UK

    H. B. Andrews

Authors
  1. J. Kornhuber
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  2. F. Mack-Burkhardt
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  3. P. Riederer
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  4. G. F. Hebenstreit
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  5. G. P. Reynolds
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  6. H. B. Andrews
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  7. H. Beckmann
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Kornhuber, J., Mack-Burkhardt, F., Riederer, P. et al. (3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients. J. Neural Transmission 77, 231–236 (1989). https://doi.org/10.1007/BF01248936

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  • DOI: https://doi.org/10.1007/BF01248936

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