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Role of Serotonergic System in Regulating Brain Tumor-Associated Neuroinflammatory Responses

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Neuroprotection

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2761))

Abstract

Serotonin signaling regulates wide arrays of both neural and extra-neural functions. Serotonin is also found to affect cancer progression directly as well as indirectly by modulating the immune cells. In the brain, serotonin plays a key role in regulating various functions; disturbance of the normal activities of serotonin leads to various mental illnesses, including the neuroinflammatory response in the central nervous system (CNS). The neuroinflammatory response can be initiated in various psychological illnesses and brain cancer. Serotonergic signaling can impact the functions of both glial as well as the immune cells. It can also affect the tumor immune microenvironment and the inflammatory response associated with brain cancers. Apart from this, many drugs used for treatment of psychological illness are known to modulate serotonergic system and can cross the blood-brain barrier. Understanding the role of serotonergic pathways in regulating neuroinflammatory response and brain cancer will provide a new paradigm in modulating the serotonergic components in treating brain cancer and associated inflammation-induced brain damages.

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Abbreviations

5-HIAA:

5-HydroxyIndole acetic acid

5-HT:

5-Hydroxytryptamine

BBB:

Blood-brain barrier

cAMP:

cyclic Adenosine mono phosphate

CNS:

Central nervous system

CTLs:

Cytotoxic T lymphocytes

DAG:

Diacylglycerol

DC:

Dendritic cells

GBM:

Glioblastoma

HTR:

Serotonin receptors

IL:

Interleukins

IP3:

Inositol-3 phosphate

MAO:

Monoamine oxidase

MDSCs:

Monocyte-derived suppressor cells

MMPs:

Matrix metalloproteinases

NF-κβ:

Nuclear factor-κβ

NK cell:

Natural killer cells

PI3K:

Phosphoionositide-3 kinase

PKA:

Protein kinase A

rDCs:

Regulatory DCs

SERT:

Serotonin transporter

SSRI:

Serotonin reuptake inhibitors

TAM:

Tumor-associated macrophages

TFIID:

Transcription factor IID

TGM2:

Transglutaminase 2

TPH:

Tryptophan hydroxylase

Tregs:

Regulatory T cells

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Declaration of Interests

The authors declare no competing interests.

Funding Supports

GL received the Swarna Jayanti Fellowship (DST/SJF/LSA-01/2017–18), from the Department of Science and Technology and a research grant from the Science and Engineering Research Board (CRG/2022/007108), Ministry of Science and Technology, Government of India. SK received a Senior Research Fellowship from the Council of Scientific and Industrial Research (CSIR), Government of India.

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    Surojit Karmakar & Girdhari Lal

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Correspondence to Girdhari Lal .

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  1. Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA

    Swapan K. Ray

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Karmakar, S., Lal, G. (2024). Role of Serotonergic System in Regulating Brain Tumor-Associated Neuroinflammatory Responses. In: Ray, S.K. (eds) Neuroprotection. Methods in Molecular Biology, vol 2761. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3662-6_14

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  • DOI: https://doi.org/10.1007/978-1-0716-3662-6_14

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3661-9

  • Online ISBN: 978-1-0716-3662-6

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