Abstract
Vascular dementia is the second most common form of dementia after Alzheimer’s disease. Chronic cerebral hypoperfusion is a key contributor to the development of vascular dementia. In this chapter, we describe the surgical procedures used for bilateral carotid artery stenosis (BCAS) surgery to induce chronic cerebral hypoperfusion. Mice that undergo BCAS surgery develop the hallmarks of vascular dementia including white matter lesions, neuroinflammation, and cognitive impairment. This technique may be used for studies of chronic cerebral hypoperfusion and vascular dementia in mice.
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© 2024 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
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Dinh, Q.N., Arumugam, T. (2024). The Bilateral Carotid Artery Stenosis (BCAS) Model of Vascular Dementia. In: Dworkin, S. (eds) Neurobiology. Methods in Molecular Biology, vol 2746. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3585-8_5
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DOI: https://doi.org/10.1007/978-1-0716-3585-8_5
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Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-3584-1
Online ISBN: 978-1-0716-3585-8
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