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Assessing the Role of Sleep in the Regulation of Emotion in PTSD

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Translational Methods for PTSD Research

Part of the book series: Neuromethods ((NM,volume 198))

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Abstract

Sleep disturbances such as trouble falling and staying asleep and recurrent trauma nightmares are common symptoms of posttraumatic stress disorder (PTSD). Although initially considered only to be a symptom of PTSD; evidence that sleep disturbance plays a critical role in the development and persistence of this disorder is accruing. In the present chapter, key literature on sleep in PTSD, methodological factors that need to be considered when planning sleep studies with PTSD populations, and psychophysiological variables closely associated with sleep in PTSD are reviewed. This is followed by a description of both traditional and novel methods for assessing sleep and sleep-associated phenomena (e.g., traditional and quantitative polysomnography, actigraphy, subjective sleep and dream measures, fear conditioning and extinction, and brain imaging during sleep) as well as a discussion of the unique methodological challenges associated with studying sleep in PTSD.

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Acknowledgements

This chapter was written while Ihori Kobayashi held an NRC Research Associateship award at Performance Assessment and Chemical Evaluation (PACE) Laboratory, Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research.

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The contents, opinions, and assertions contained herein are the private views of the authors and are not to be considered as official or reflecting the view of Walter Reed Army Institute of Research, the Department of the Army, or the Department of Defense.

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Authors and Affiliations

  1. Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA

    Ihori Kobayashi, Kilana D. Jenkins & Fred L. Johnson III

  2. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands

    Mariana E. Pereira

  3. Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA

    Edward F. Pace-Schott

  4. Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA

    Edward F. Pace-Schott

  5. Department of Psychiatry, Harvard Medical School, Charlestown, MA, USA

    Edward F. Pace-Schott

Authors
  1. Ihori Kobayashi
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  2. Mariana E. Pereira
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  3. Kilana D. Jenkins
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  4. Fred L. Johnson III
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  5. Edward F. Pace-Schott
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Corresponding author

Correspondence to Ihori Kobayashi .

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Editors and Affiliations

  1. Psychiatric Institute, University of Chicago, Chicago, IL, USA

    Graziano Pinna

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Kobayashi, I., Pereira, M.E., Jenkins, K.D., Johnson, F.L., Pace-Schott, E.F. (2023). Assessing the Role of Sleep in the Regulation of Emotion in PTSD. In: Pinna, G. (eds) Translational Methods for PTSD Research. Neuromethods, vol 198. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3218-5_4

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  • DOI: https://doi.org/10.1007/978-1-0716-3218-5_4

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3217-8

  • Online ISBN: 978-1-0716-3218-5

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