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Radiopharmaceuticals in the Management of Leptomeningeal Metastasis

  • Book
  • © 2022

Overview

Editors:
  1. Franklin C.L. Wong

    1. Dept of Nuclear Med, Unit No 1483, U Texas MD Anderson Cancer Ctr, Houston, USA

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  • Offers a comprehensive review of LM treatment using radionuclides
  • Includes updated scientific modeling and imaging algorithms
  • Written with direct experience from practicing nuclear physicians, neurologists, and oncologists

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xi
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  2. Human Leptomeningeal Metastasis (LM): Epidemiology and Challenges

    • Brian S. Wong, Franklin C. L. Wong
    Pages 1-8

  3. State of Art of LM Radiographic Diagnosis: Anatomic and Functional Imaging

    • J. Matthew Debnam, T. Linda Chi
    Pages 9-20

  4. Radionuclides in the Diagnosis and Therapy in Neuro-Oncology

    • Rodolfo Núñez
    Pages 21-69

  5. Scintigraphy of Human CSF Flow in Patients with Leptomeningeal Metastasis

    • Franklin C. L. Wong, Ian E. McCutcheon
    Pages 71-99

  6. State of Art of LM Therapies: Intrathecal and Systemic Approaches

    • Hannah Culver, Morris D. Groves Jr
    Pages 101-124

  7. Radiation Therapy for Leptomeningeal Disease

    • Samantha M. Buszek, Caroline Chung
    Pages 125-141

  8. Neurophysiology Evaluation in Leptomengeal Metastasis Disease

    • Sudhakar Tummula
    Pages 143-148

  9. Radionuclide Leptomeningeal Metastasis Therapy Trials

    • Franklin C. L. Wong
    Pages 149-159

  10. Simulated Radiation Dosimetry Models After Intraventricular and Intralumbar Injection of Radiopharmaceuticals

    • Franklin C. L. Wong, Richard B. Sparks
    Pages 161-185

  11. Human Radiation Dosimetry from Imaging: Guidance for Therapy

    • Richard E. Wendt III
    Pages 187-198

  12. Regulatory Oversight of Radiopharmaceuticals

    • Dao Le
    Pages 199-213

  13. Radionuclides in the Management of Leptomeningeal Metastasis: Framework and Opportunities

    • Franklin C. L. Wong
    Pages 215-226

  14. Back Matter

    Pages 227-232
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Keywords

About this book

This book reviews the current clinical practice of leptomeningeal metastasis (LM) diagnosis and treatment, which is predominately by intrathecal chemotherapy and/or in combination with external beam radiotherapy.  LM is a refractory lethal complication of many human malignancies when neoplastic cells grow in the meninges. The use of penetrating emissions from radionuclides has the advantages of visualizing cerebrospinal fluid (CSF) flow and ablating meninges at shallow depths and has been used to diagnose CSF flow anomalies and to treat LM.  The scientific bases of using radionuclides inside human CSF and ablating LM will be discussed within the text, with results from established and completed clinical trials to explore optimal use of radionuclides to diagnose and treat LM. Many limitations of current practices of treating LM are also discussed, as well as potential avenues of overcoming these limitations. This book is an ideal guide for clinical researchers in the practice of treating leptomeningeal metastasis including radiologists, neurologists, oncologists and radiotherapists as well as their associates.

Editors and Affiliations

  • Dept of Nuclear Med, Unit No 1483, U Texas MD Anderson Cancer Ctr, Houston, USA

    Franklin C.L. Wong

About the editor

Franklin C.L. Wong, MD, PhD, JD is Professor of Nuclear Medicine and Neuro-Oncology at The University of Texas M. D. Anderson Cancer Center. He has published extensively, both original articles and book chapters, in nuclear medicine. 

Bibliographic Information

  • Book Title: Radiopharmaceuticals in the Management of Leptomeningeal Metastasis

  • Editors: Franklin C.L. Wong

  • DOI: https://doi.org/10.1007/978-3-031-14291-8

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2022

  • Softcover ISBN: 978-3-031-14290-1Published: 13 November 2022

  • eBook ISBN: 978-3-031-14291-8Published: 12 November 2022

  • Edition Number: 1

  • Number of Pages: XI, 232

  • Topics: Nuclear Medicine, Oncology, Neurology

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