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Radiation Therapy for Leptomeningeal Disease

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Radiopharmaceuticals in the Management of Leptomeningeal Metastasis

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Abstract

Leptomeningeal disease (LMD) occurs in approximately 5% of all cancer patients, presenting most commonly in primary diagnoses of breast cancer, lung cancer, gastrointestinal tract malignancies, and melanoma. Radiation therapy (RT) is commonly incorporated as a part of the multimodal approach in the treatment of LMD and has traditionally been recommended for patients with bulky or symptomatic metastatic sites of LMD to provide symptom relief, CSF flow correction, or for debulking of disease to facilitate further systemic therapy. Several RT techniques have been utilized for the treatment of LMD, including involved-field RT, whole brain RT, and craniospinal irradiation.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Samantha M. Buszek & Caroline Chung

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  1. Samantha M. Buszek
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  2. Caroline Chung
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Correspondence to Caroline Chung .

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  1. Dept of Nuclear Med, Unit No 1483, U Texas MD Anderson Cancer Ctr, Houston, TX, USA

    Franklin C.L. Wong

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Buszek, S.M., Chung, C. (2022). Radiation Therapy for Leptomeningeal Disease. In: Wong, F.C. (eds) Radiopharmaceuticals in the Management of Leptomeningeal Metastasis. Springer, Cham. https://doi.org/10.1007/978-3-031-14291-8_6

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  • DOI: https://doi.org/10.1007/978-3-031-14291-8_6

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