1. Rationale for Monitoring Free Drug Levels

   • René H. Levy
   • Terence A. Moreland

   OriginalPaper 13 December 2012 Pages: 1 - 9

2. Protein Binding and Drug Clearance

   • Malcolm Rowland

   OriginalPaper 13 December 2012 Pages: 10 - 17

3. Alteration of Drug-Protein Binding in Renal Disease

   • Marcus M. Reidenberg
   • Dennis E. Drayer

   OriginalPaper 13 December 2012 Pages: 18 - 26

4. α₁-Acid Glycoprotein and Plasma Lidocaine Binding

   • David G. Shand

   OriginalPaper 13 December 2012 Pages: 27 - 31

5. Pharmacokinetic Consequences of Drug Displacement from Blood and Tissue Proteins

   • Janis J. MacKichan

   OriginalPaper 13 December 2012 Pages: 32 - 41

6. Effect of Concentration-Dependent Binding to Plasma Proteins on the Pharmacokinetics and Pharmacodynamics of Disopyramide

   • Kathleen M. Giacomini
   • Terrence F. Blaschke

   OriginalPaper 13 December 2012 Pages: 42 - 48

7. Ultrafiltration vs Equilibrium Dialysis for Determination of Free Fraction

   • William F. Bowers
   • Scott Fulton
   • Judith Thompson

   OriginalPaper 13 December 2012 Pages: 49 - 60

8. The EMIT® FreeLevel™ Ultrafiltration Technique Compared with Equilibrium Dialysis and Ultracentrifugation to Determine Protein Binding of Phenytoin

   • Michael Oellerich
   • H. Müller-Vahl

   OriginalPaper 13 December 2012 Pages: 61 - 70

9. Free Level Monitoring of Antiepileptic Drugs Clinical Usefulness and Case Studies

   • E. Perucca

   OriginalPaper 13 December 2012 Pages: 71 - 78

10. Potential Applications of Free Drug Level Monitoring in Cardiovascular Therapy†

    • Raymond L. Woosley
    • Lyle A. Siddoway
    • Dan M. Roden

    OriginalPaper 13 December 2012 Pages: 79 - 83

11. The Relative Importance of Albumin, Lipoproteins and Orosomucoid for Drug Serum Binding

    • E. Pike
    • B. Skuterud
    • P. K. M. Lunde

    Short Communications 13 December 2012 Pages: 84 - 85

12. Influence of pH and Buffer Type on Drug Binding in Human Serum

    • Odd Brørs
    • Odd G. Nilsen
    • Sten Jacobsen

    Short Communications 13 December 2012 Pages: 85 - 86

13. Comparison of Equilibrium Dialysis, Ultrafiltration and Ultracentrifugation to Determine the Plasma Protein Binding Characteristics of a Drug: Application to Valproic Acid

    • J. Barre
    • J. M. Chamouard
    • J. P. Tillement

    Short Communications 13 December 2012 Pages: 86 - 87

14. Serum and Plasma for Total and Free Anticonvulsant Drug Analyses

    • William Godolphin
    • Joan Trepanier
    • Kevin Farrell

    Short Communications 13 December 2012 Pages: 87 - 88

15. Exogenous and Endogenous Factors Influencing Unbound Antiepileptic Drug Concentrations

    • Dorothy D. Schottelius

    Short Communications 13 December 2012 Pages: 88 - 89

16. Therapeutic Free Phenytoin Monitoring

    • S. M. Bryson
    • J. C. Kelly
    • B. Whiting

    Short Communications 13 December 2012 Pages: 90 - 90

17. Single Feedback Bayesian Forecasts with Free and Total Phenytoin Concentrations

    • Robert W. Coleman
    • Ihor Krewsun
    • Rebecca L. Kelber

    Short Communications 13 December 2012 Pages: 90 - 92

18. Phenytoin and Carbamazepine Serum Protein Binding in a Geriatric Patient Population

    • Peter Gal
    • Karen S. Oles
    • Wallace H. Baird

    Short Communications 13 December 2012 Pages: 92 - 93

19. Diurnal Fluctuations in Free and Total Plasma Concentrations of Carbamazepine at Steady-State and Correlation with Intermittent Side Effects in Epileptic Patients

    • Roberto Riva
    • Fiorenzo Albani
    • Agostino Baruzzi

    Short Communications 13 December 2012 Pages: 93 - 94

20. Utilisation of Free Valproic Acid Determinations

    • Joyce A. Cramer
    • Richard H. Mattson
    • David M. Bennett

    Short Communications 13 December 2012 Pages: 94 - 95

21. Factors Affecting the Measurement of Lidocaine Protein Binding by Equilibrium Dialysis

    • K. V. Ponganis
    • D. R. Stanski

    Short Communications 13 December 2012 Pages: 95 - 95

22. Measurement of Free Lidocaine Serum Concentration by Equilibrium Dialysis and Ultrafiltration Techniques: The Influence of pH and Heparin

    • H. R. Ha
    • S. Vozeh
    • F. Follath

    Short Communications 13 December 2012 Pages: 96 - 96

23. Factors Affecting Quinidine Protein Binding in Man

    • D. J. Edwards
    • J. E. Axelson
    • D. Lalka

    Short Communications 13 December 2012 Pages: 96 - 97

24. Disopyramide Protein Binding and α₁-Acid Glycoprotein Concentrations in Serum Obtained from Kidney Transplant Recipients

    • David B. Haughey
    • Cheryl J. Kraft

    Short Communications 13 December 2012 Pages: 97 - 98

25. Effect of Several Variables on the In Vitro Binding of Disopyramide to Serum Proteins

    • Leslie M. Shaw
    • Roy Altman
    • Leona Fields

    Short Communications 13 December 2012 Pages: 98 - 99

26. Relationships between Steady-State Warfarin Concentrations and Anticoagulant Effect

    • Dennis Mungall
    • Thomas M. Ludden
    • David Hawkins

    Short Communications 13 December 2012 Pages: 99 - 100

27. Dexamethasone Decreases Plasma Protein Binding of Prazosin In Vivo in Rabbits

    • Maria K. Witkowska
    • Terrence F. Blaschke

    Short Communications 13 December 2012 Pages: 100 - 101

28. Panel Discussion

    • D. Shand

    Panel Discussion 13 December 2012 Pages: 102 - 104